Use of liver graft infested with clonorchis sinensis for living related liver transplantation: a case report

Hwang, Young‐Hyun; Kim, Y.I; Yun, Youngjun; Kim, J.W

doi:10.1016/s0041-1345(00)01625-0

Cited by 9 publications

(8 citation statements)

References 2 publications

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“…In four of the cases, in the donors' preoperative studies, abnormalities of the bile ducts were found on CT scanning, and ova of Clonorchis spp. were identified in stool samples (185). In one of the cases, the preoperative study was normal, but during the surgery, minimal bile duct inflammation was observed (222).…”

Section: Infections Caused By Trematodesmentioning

confidence: 94%

“…Six cases where a liver graft infected with Clonorchis spp. has been transplanted have been described (169,185,222,411). In four of the cases, in the donors' preoperative studies, abnormalities of the bile ducts were found on CT scanning, and ova of Clonorchis spp.…”

Section: Infections Caused By Trematodesmentioning

confidence: 99%

“…Parasites were identified in the bile ducts in all cases, and intraoperative irrigation of the ducts was performed. Treatment with praziquantel was administered in three of the cases: in two of these cases, it was given to the donor pretransplant (185,222), and in the other case, it was given to the donor and recipient in the posttransplant period (222).…”

Section: Infections Caused By Trematodesmentioning

confidence: 99%

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Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Infections Caused By Trematodesmentioning

confidence: 94%

Section: Infections Caused By Trematodesmentioning

confidence: 99%

Section: Infections Caused By Trematodesmentioning

confidence: 99%

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Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…To date, only 20 cases of transplanted liver grafts infested with C. sinensis (Table ) and 7 with S. mansoni have been reported in the literature . All the liver transplantations with grafts infested with C. sinensis (18 in adult and 2 in pediatric recipients) were performed in East Asian countries, 16 of which were deceased‐donor living transplantation and 5 LDLT.…”

Section: Discussionmentioning

confidence: 99%

“…Liver flukes were suspected preoperatively in only 2 cases (both LDLT) because of intrahepatic ductal dilatation seen on computed tomography . Only 1 of them also presented eosinophilia .…”

Section: Discussionmentioning

confidence: 99%

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Capobianco¹,

Frank

Königsrainer³

et al. 2015

Transplant Infectious Dis

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Clonorchiasis is a cholangiopathy caused by foodborne trematode parasites, also known as liver flukes. Clonorchiasis is endemic in a wide geographical area extending from Eastern Europe to Southeast Asia. Infested hosts may remain asymptomatic for decades and consequently their liver can become available as a graft. To date, 20 liver transplantations with liver fluke-infested grafts have been reported in the literature. All of them occurred in Asian countries. We, here, report the first case to our knowledge in the Western world of living-donor liver transplantation (LDLT) with an Opisthorchis felineus-infested graft, and present a review of the literature. A 6-month-old girl with decompensated secondary biliary cirrhosis underwent an LDLT with a left lateral graft infested with O. felineus. After prompt diagnosis and adequate therapy, both donor and recipient had an uneventful postoperative course and long-term follow-up. Liver grafts infested with liver flukes do not pose a contraindication to liver donation from deceased or living donors, provided that a correct diagnosis and treatment are performed in a timely fashion.

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Feasibility of using a liver infected with Clonorchis sinensis for liver transplantation: Fourteen cases

Zhu¹,

Shen²,

Gao³

et al. 2010

Liver Transpl

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Use of livers infected with Clonorchis sinensis as donor organs for transplantation is controversial because of the potential associated risks. The low availability of donor livers at Tianjin First Center Hospital since 2003 prompted us to undertake cadaveric liver transplantation in 14 patients using donor livers infected with C. sinensis. None of the donors had been diagnosed with liver fluke infection before organ procurement, and in none of them was there laboratory evidence of abnormal liver function. After livers had been harvested and preserved, dead liver flukes were found in the bile of each donor; subsequent pathological examination of the flukes confirmed the diagnosis of clonorchiasis. Conventional orthotopic liver transplantation, with insertion of a T-tube, was undertaken in all 14 patients. Praziquantel, 25 mg/kg three times daily for two days, was administrated to the recipients starting on postoperative day 2. Results of tests of liver function improved rapidly after the operation in all of the patients. The median duration of follow-up was 31 months. The 1-and 3-year survival rates of the grafts were 85.7% and 78.6%, respectively. Postoperative biliary complications occurred in 2 patients (14.3%). No ova were detected in the bile or feces of any of the patients postoperatively. These findings suggest that livers infested with C. sinensis can be used as donor organs for liver transplantation. Further studies are required to establish definitive criteria for determining whether such donor organs may be used in a liver transplantation program.

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Use of liver graft infested with clonorchis sinensis for living related liver transplantation: a case report

Cited by 9 publications

References 2 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Feasibility of using a liver infected with Clonorchis sinensis for liver transplantation: Fourteen cases

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