Use of Macrolane to Treat Pectus Excavatum

Sinna, R.; Perignon, D.; Assaf, N.; Berna, Pascal

doi:10.1016/j.athoracsur.2011.09.054

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…An average volume of 157 mL (range, 80-245 mL) of HA gel was injected in total at baseline and touch-up; this injection volume is somewhat larger than what has been reported for similar procedures. 25,31 A volume of 50 to 150 mL HA gel was estimated as sufficient and recommended to provide correction of the deformity. Estimating the filler volume required is, however, difficult due to the irregularity of the defect, and therefore a step-wise approach of filler administration over different appointments is common.…”

Section: Discussionmentioning

confidence: 99%

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An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment

Hedén¹,

Sinna

2018

Aesthetic Surgery Journal

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Background Pectus excavatum (PE) is sometimes associated with psychological and physiological difficulties influencing a patient’s quality of life. Treatment with a hyaluronic acid (HA)-based gel may benefit patients and be an alternative to other more invasive treatments. Objectives The authors sought to evaluate the effectiveness in terms of satisfaction, duration, and safety of HA gel treatment for PE including impact on quality of life. Methods Males ≥18 years having PE without functional problems received HA gel injections (50 – 150 mL) at the site of deformity and in some cases at the medial pectoralis muscle borders to optimize the aesthetic result. Follow-up visits were performed after 1, 3, 6, 12, and 24 months with optional retreatment at the 24-month visit including a 1-month follow-up. Evaluations included Pectus Excavatum Evaluation Questionnaire, patient satisfaction, magnetic resonance imaging, and safety assessments. Results The treatment significantly improved patients’ self-esteem ( P < 0.001) and psychosocial function ( P ≤ 0.038) throughout the study, as assessed by Pectus Excavatum Evaluation Questionnaire. Patients were satisfied with the aesthetic outcome and considered the treatment mild in terms of level of pain during injection. Treatment effects were maintained up to 24 months and 58% of the HA gel remained at this visit, shown by Magnetic Resonance Imaging measurements. The treatment was well tolerated. Conclusions Treatment of PE with HA gel improved patient quality of life related to self-esteem and psychosocial functioning including aesthetically pleasing results. The treatment may also offer benefits in terms of safety and tolerability compared with other treatments. Level of Evidence: 4

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Section: Discussionmentioning

confidence: 99%

“…Indeed, Sinna and colleagues have reported encouraging results of a PE treatment case employing HA gel where the patient quickly returned to normal life without major complications. 25 Note that the HA gel product was, as of November 2016, discontinued.…”

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confidence: 99%

An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment

Hedén¹,

Sinna

2018

Aesthetic Surgery Journal

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“…Diese galenischen Eigenschaften machen Körperfiller auf HA-Basis einsetzbar zur Wiederherstellung von Volumen und zur Formung ganz verschiedener Körperzonen [36]. Einsatzgebiete sind die Korrektur von Pectus excavatum [37] und von postoperativen Liposuktionsdefiziten [38] sowie die Penisvergrößerung [39] und die Modellierung der Gluteal-und Unterschenkelregion ( [40,41]; . Abb.…”

Section: Hyaluronsäurefillerunclassified

Body contouring

2015

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In our contemporary postmodern society, a modified perception of the human body is accompanied by an increasing demand for body shaping procedures. The treatment needs to be effective but it is just as important that they are safe and can be easily integrated into the daily working and routine schedule. While the options for minimally invasive volume addition are largely limited to injectable implants based on hyaluronic acid or autologous fat, a multitude of options are available for volume reduction. Before deciding on the method of choice, the following needs to be considered: which indications need to be treated, the extent of the reduction in volume and how much pain and possible undesired reactions the patient is prepared to accept.

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“…Hyaluronic acid, applied millions of times in aesthetic medicine for the treatment of wrinkles in the aging face, also found its way to physicians who occasionally use it to fill in a PE deformity (32). Apart from the prohibitive price due to the large volume needed to induce a visible improvement, the effect is only temporary due to resorption and the funnel will relapse to its original extent one to two years after injection.…”

Section: Macrolanementioning

confidence: 99%

Pectus excavatum repair from a plastic surgeon’s perspective

Schwabegger

2016

Ann. Cardiothorac. Surg.

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Minimally invasive repair of pectus excavatum (MIRPE) or similar procedures for pectus excavatum (PE) repair, nowadays no longer performed by one single speciality, may not always achieve sufficient aesthetic results, particularly in the infrapectoral or infraxiphoidal region. Reasons for this include the diaphragm inhibiting correct positioning of the bars, as well as asymmetric deformities which may still be present after remodelling attempts. Furthermore, some cases develop a mild recurrence or partial concavity once the correction bar is removed. However, any secondary re-do MIRPE procedure remains risky because of adhesions between the pleura, lung, pericardium, thoracic wall as residuals from the primary intervention.

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Use of Macrolane to Treat Pectus Excavatum

Cited by 10 publications

References 6 publications

An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment

An Open, Prospective Study to Evaluate the Effectiveness and Safety of Hyaluronic Acid for Pectus Excavatum Treatment

Body contouring

Pectus excavatum repair from a plastic surgeon’s perspective

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