Use of magnetic nanoparticles to monitor alginate‐encapsulated βTC‐tet cells

The emerging field of pancreatic tissue engineering: A systematic review and evidence map of scaffold materials and scaffolding techniques for insulin-secreting cells

“…61 The controllable generation of these droplets or the encapsulation of cells in general can be achieved by various techniques such as microfluidic devices (Figure 4(a)), pressure-based air jacket microencapsulation, vibrational jet flow technology, electrostatic droplet generation, or manual syringe-based extrusion into a chemical crosslinking solution (Figure 4(b)). 18,19,56,57,59,62–76 Most droplet-generation methods for cell encapsulation used extrusion-based systems, where a cell-containing hydrogel solution will be extruded through a needle. Depending on the viscosity of the hydrogel, the diameter of the needle, and the flow rate or extrusion pressure, a droplet will be generated.…”

The biodistribution of [153Gd]Gd‐labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice

“…All of the data are presented as mean ± SD or mean (95% Confidence Interval). Statistical classifications routinely used to analyze biodistribution data were performed as previously described (19–25). Briefly, a student's t ‐test (two‐tailed, unpaired) was used when comparing two groups (control vs. RI), whereas an one way Anova test, which was used to compare all three GCAs, was performed using GraphPad Prism (San Diego, CA).…”

A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant

“…[39] While both approaches utilized cell labeling through culture and reliance on cellular uptake of GBCA, other approaches included encapsulation with Gd-bound or Gdcontaining microstructures as has also been demonstrated with other contrast agents; encapsulation with Gd-Gold microcapsules, Gd-containing alginate nanoparticles, and Gd-silica alginate nanoparticles have all been used. [40][41][42] These approaches have been shown to be associated with no adverse effects up to 4 weeks post-implantation. As mentioned elsewhere in this review, approaches utilizing encapsulation have the added benefit of potentially limiting immune response to transplanted islets and improving their long-term viability following transplant.…”