Use of maternal plasma level of zinc-coproporphyrin in the prediction of intrauterine passage of meconium: A pilot study

Usta, Ihab M.; Sibai, BM; Mercer, Brian M.; Kreamer, Bill L.; Gourley, Glenn R.

doi:10.1002/1520-6661(200007/08)9:4<201::aid-mfm2>3.0.co;2-l

Cited by 15 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,11 Meconium has been shown to be present in clear human AF. 12 Thus, AF is considered to be one of the responsible factors for the harmful effects on intestines in fetus with gastroschisis besides restricted blood flow due to constriction by the abdominal wall defect. [6][7][8] Additionally, AF exerts adverse effects on neural tissue in fetus with myelomeningocele besides physical damage to the exposed neuronal tissue from coming into contact with the inner uterine wall.…”

Section: Introductionmentioning

confidence: 99%

The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: An animal study

Ateş

Hakgüder

Olguner

et al. 2006

Pediatric Pulmonology

View full text Add to dashboard Cite

Tracheal mucosal damage has been reported in autopsy specimens of cases with proximal esophageal atresia and distal tracheoesophageal fistula (EA-TEF) (Gross classification type C). Such changes have not been reported for isolated EA (Gross classification type A). Our hypothesis is that passage of amniotic fluid (AF) through fistula via larynx and trachea may damage tracheal mucosa. An experimental study was conducted to investigate this hypothesis in the Adriamycin-induced EA-TEF model. In the first stage of the study, we tested whether the fetuses with EA-TEF associated with pyloric atresia cannot swallow AF whereas the fetuses EA-TEF without intestinal atresia can swallow AF. Carbon solution was injected into the AF for this purpose. In the second stage of study, at the 21st day of their gestation, fetuses were extirpated and dissected under microscope. In both stages, fetuses were divided into four groups as control, fetuses without tracheoesophageal abnormalities, fetuses with EA-TEF only, fetuses with pyloric atresia associated with EA-TEF. Lungs and tracheas of the all fetuses were removed for histopathological examination. While carbon particles were present in the trachea, stomachs of the fetuses without tracheoesophageal anomalies, with EA-TEF only and control fetuses, carbon particles were absent in both trachea and stomachs of the fetuses with pyloric atresia associated with EA-TEF. Histopatological examination of the tracheal mucosa showed damage throughout the trachea in the fetuses with EA-TEF only group. Tracheal mucosa was found to be normal in other groups. Bronchial mucosa and lung tissues were found to be normal in all groups. Amniotic fluid swallowed through the TEF causes histopathological changes in the tracheal mucosa of the fetuses with EA-TEF only group. These findings may also contribute to the development of new fetal treatment modalities.

show abstract

Section: Introductionmentioning

confidence: 99%

The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: An animal study

Ateş

Hakgüder

Olguner

et al. 2006

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…1 Meconium also contains pancreatic enzymes, free fatty acids, porphyrins, interleukin-8, and phospholipase A2. 2 3 Its color is believed to be attributed to bile pigments excreted by the biliary tract from the fourth month of gestation onward. 4…”

mentioning

confidence: 99%

“…1 Meconium also contains pancreatic enzymes, free fatty acids, porphyrins, interleukin-8, and phospholipase A2. 2,3 Its color is believed to be attributed to bile pigments excreted by the biliary tract from the fourth month of gestation onward. 4 Meconium is typically defecated after birth, since 98% of healthy newborns pass meconium within the first 24 to 48 hours after birth, but may occasionally be discharged into the amniotic fluid during labor.…”

mentioning

confidence: 99%

Correlation of Meconium-Stained Amniotic Fluid and Adverse Pregnancy Outcomes between 37 to 39 and 40 to 42 Weeks of Gestational Age

et al. 2023

View full text Add to dashboard Cite

Objective: We aimed at assessing the association between MSAF and adverse maternal and neonatal outcomes in early-term versus late-term pregnancies. Methods: Early term pregnancies (37-39 weeks of gestation) presented with MSAF were compared to late-term (40-42 weeks of gestation) pregnancies with MSAF. The groups were compared with respect to background characteristics, maternal outcomes and neonatal outcomes. The composite neonatal outcome was the primary outcome of the study, and secondary outcomes included the maternal and neonatal outcomes. Results: The early term group comprised 239 women, compared with 362 women in the late term group. The primary outcome did not differ between groups. We found a higher prevalence of gestational diabetes (8.37% versus 3%, P<0.05), a shorter second stage of labor (45.6154.67 versus 65.8262.99 minutes, P<0.05), and a longer hospital stay (2.842.21 versus 2.531.26 days, P<0.05) in the early-term group. Other maternal and neonatal characteristics and outcomes were not significantly different between the two groups. Conclusion: In term pregnancies complicated by MSAF, adverse neonatal and maternal delivery outcomes are equivalent, regardless of gestational age, and therefore any term pregnancy complicated by MSAF should be considered high risk and managed appropriately.

show abstract

Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections

Siriwachirachai

Sangkomkamhang

Lumbiganon

et al. 2014

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Use of maternal plasma level of zinc-coproporphyrin in the prediction of intrauterine passage of meconium: A pilot study

Cited by 15 publications

References 13 publications

The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: An animal study

The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: An animal study

Correlation of Meconium-Stained Amniotic Fluid and Adverse Pregnancy Outcomes between 37 to 39 and 40 to 42 Weeks of Gestational Age

Antibiotics for meconium-stained amniotic fluid in labour for preventing maternal and neonatal infections

Contact Info

Product

Resources

About