In this study, the efficiency of Integrated Fixed-film Activated Sludge (IFAS) system in synthetic greywater treatment and nutrients removal was studied in duration of 105 days according to different Organic Loadings Rates (OLRs). The study was operated in pilot-scale and OLRs of 0.11–1.3 gCOD/L.d. Scanning Electron Microscope (SEM) image showed that the biofilm with a proper thickness was formed on IFAS reactor’s media. The results indicated that the best removal efficiency of BOD5, COD, and TSS were 85.24, 92.52 and 90.21%, respectively, in an organic loading of 0.44 gCOD/L.d. Then, with the OLR increased, the removal efficiencies of BOD5, COD, and TSS increased as long as the organic loading reached 0.44 gCOD/L.d. But with the OLR increased more, the removal efficiency of these parameters decreased. The ANOVA statistical test results showed that the mean difference of removal efficiency in organic loadings for BOD5 (p ≤ 0.001) and COD (p = 0.003) was significant, while it was insignificant for TSS (p = 0.23). The best removal efficiencies of Total Nitrogen (TN) and Total Phosphorus (TP) were 89.60 and 86.67%, respectively, which were obtained at an OLR of 0.44 gCOD/L.d. By increasing OLR up to 0.44 gCOD/L.d, removal efficiencies of TN and TP increased, while the removal efficiency decreased with the OLR increased more, and this difference was statistically significant (p = 0.021). Finally, the results showed that the IFAS system provided a proper efficiency in treatment of the synthetic greywater and it could be used in a full scale.