Use of Megavoltage Therapy in Cancer: End-Results

Stein, Justin J.; Ottoman, Richard E.; Langdon, Edward A.; Gore, William A.

doi:10.1148/79.2.181

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, advances in childhood NB treatment have been achieved, which has resulted in a longer survival rate (Saletta et al, 2014). In many pediatric malignancies, external irradiation with mega-voltage beams is usually considered as an alternative for disease management (Stein et al, 1962;Zhang et al, 2015). Radiotherapy is given after the completion of induction chemotherapy and tumor resection.…”

Section: Radiotherapymentioning

confidence: 99%

The quest to develop an effective therapy for neuroblastoma

Bhoopathi

Padmanabhan

Emdad

et al. 2021

Journal Cellular Physiology

View full text Add to dashboard Cite

Neuroblastoma (NB) is a common solid extracranial tumor developing in pediatric populations. NB can spontaneously regress or grow and metastasize displaying resistance to therapy. This tumor is derived from primitive cells, mainly those of the neural crest, in the sympathetic nervous system and usually develops in the adrenal medulla and paraspinal ganglia. Our understanding of the molecular characteristics of human NBs continues to advance documenting abnormalities at the genome, epigenome, and transcriptome levels. The high-risk tumors have MYCN oncogene amplification, and the MYCN transcriptional regulator encoded by the MYCN oncogene is highly expressed in the neural crest. Studies on the biology of NB has enabled a more precise risk stratification strategy and a concomitant reduction in the required treatment in an expanding number of cases worldwide. However, newer treatment strategies are mandated to improve outcomes in pediatric patients who are at high-risk and display relapse. To improve outcomes and survival rates in such high-risk patients, it is necessary to use a multicomponent therapeutic approach. Accuracy in clinical staging of the disease and assessment of the associated risks based on biological, clinical, surgical, and pathological criteria are of paramount importance for prognosis and to effectively plan therapeutic approaches. This review discusses the staging of NB and the biological and genetic features of the disease and several current therapies including targeted delivery of chemotherapy, novel radiation therapy, and immunotherapy for NB.

show abstract

Section: Radiotherapymentioning

confidence: 99%

The quest to develop an effective therapy for neuroblastoma

Bhoopathi

Padmanabhan

Emdad

et al. 2021

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…This type of energy is used rather historically. The second and most commonly used is megavolt radiotherapy, which uses gamma or X-rays [ 58 , 59 ]. In order to increase the effectiveness of treatment of cancer patients, very often combination therapy is used.…”

Section: The Role Of Radiotherapy In the Treatment Of Tc And At Carcinoidsmentioning

confidence: 99%

The Role of Conventionally Fractionated Radiotherapy and Stereotactic Radiotherapy in the Treatment of Carcinoid Tumors and Large-Cell Neuroendocrine Cancer of the Lung

Bilski

Mertowska

Mertowski

et al. 2021

Cancers

View full text Add to dashboard Cite

The occurrence of neuroendocrine tumors among the diagnosed neoplasms is extremely rare and is associated with difficulties in undertaking effective therapy due to the histopathological differentiation of individual subtypes and the scarce clinical data and recommendations found in the literature. The choice of treatment largely depends not only on its type, but also on the location and production of excess hormones by the tumor itself. Common therapeutic approaches include surgical removal of the tumor, the use of chemotherapy, targeted drug therapy, peptide receptor radionuclide therapy, and the use of radiation therapy. This article reviews the current knowledge on the classification and application of radiotherapy in the treatment of lung NETs. Case reports were presented in which treatment with conventional radiotherapy, radical and palliative radiochemotherapy, as well as stereotactic fractionated radiotherapy in the treatment of typical (TC) and atypical (AT) lung carcinoids and large cell neuroendocrine carcinoma (LCNC) were used. We hope that the solutions presented in the literature will allow many radiation oncologists to make the best, often personalized decisions about the therapeutic qualifications of patients.

show abstract

Comparative Trial of Surgery and Radiotherapy for the Primary Treatment of Small-Celled or Oatcelled Carcinoma of the Bronchus

1966

The Lancet

View full text Add to dashboard Cite

Use of Megavoltage Therapy in Cancer: End-Results

Cited by 7 publications

References 0 publications

The quest to develop an effective therapy for neuroblastoma

The quest to develop an effective therapy for neuroblastoma

The Role of Conventionally Fractionated Radiotherapy and Stereotactic Radiotherapy in the Treatment of Carcinoid Tumors and Large-Cell Neuroendocrine Cancer of the Lung

Comparative Trial of Surgery and Radiotherapy for the Primary Treatment of Small-Celled or Oatcelled Carcinoma of the Bronchus

Contact Info

Product

Resources

About