Use of metal-containing polymers as potential anticancer agents

Abstract

Metal containing polymers have been synthesized from a variety of metals that exhibit good inhibition of a variety of human cancer cell lines including pancreatic and breast human cancer cell lines. The products are rapidly synthesized using commercially available reactants and a system that is employed industrially allowing for ready expansion of the amounts of products synthesized. Recently, water soluble polymers have been synthesized using poly(ethylene glycol).

Syntheses, Structural Characterization, and Cytotoxicity Assessment of Novel Mn(II) and Zn(II) Complexes of Aroyl-Hydrazone Schiff Base Ligand

“… The calculated binding constant values for L1 and complexes 1 and 2 were found to be 8.89(±0.04) × 10 3 , 4.54­(±0.17) × 10 4 , and 6.78(±0.11) × 10 4 M –1 , respectively, which substantiates the more avid binding of complex 2 than complexes 1 and Ls1 . The better binding profile of complex 2 could be attributed to its polymeric nature and the specific topology, which facilitates multiple binding interactions with DNA …”

“…The better binding profile of complex 2 could be attributed to its polymeric nature and the specific topology, which facilitates multiple binding interactions with DNA. 47 …”

“…However, complex 2 demonstrated selective cytotoxic activity against the A549 cell line with a fairly low IC 50 value of 17.54 μM (Figure ). The selective cytotoxic activity of complex 2 against A549 cancer cells may be attributed to its polymeric structure, which facilitates multiple binding interactions between the target and complex 2 . , Additionally, the cytotoxicity of polymeric complex 2 against the A549 cancer cell line was compared with previously reported similar zinc hydrazone Schiff base complexes, and cisplatin. Complex 2 demonstrated better cytotoxicity against the tested cancer cell line in comparison to the previously reported zinc hydrazone Schiff base complexes and cisplatin, which was evidenced from their IC 50 value (Table S13).…”