Use of methylphenidate in patients with cancer

Sood, Amit; Barton, Debra L.; Loprinzi, Charles L.

doi:10.1177/104990910602300106

Cited by 60 publications

(33 citation statements)

References 43 publications

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“…Methylphenidate and related stimulants are widely used in cancer and palliative care, and these stimulants improve mood, appetite, energy, and cognition. [57][58][59] Stimulants act rapidly (24-48 hours), counter opioid-related sedation, and have adjuvant analgesic activity. They are the treatment of choice when time is short, and they are often combined with a selective serotonin reuptake inhibitor (SSRI) in severe depression.…”

Section: Treatmentmentioning

confidence: 99%

Psychiatric disorders in advanced cancer

Miovic

Block

2007

Cancer

321

228

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Label‐free microcolony identification via elastic light scattering was investigated for three different genera: Salmonella enterica serovar Montevideo, Listeria monocytogenes F4244, and Escherichia coli DH5α. Microcolonies were defined as bacterial colonies in their late‐lag phase to early‐exponential phase with the diameter range of 100–200 µm. To link biophysical characteristics with corresponding scattering patterns, a phase contrast microscope and a confocal displacement meter were used to measure the colony diameter and its 3D height profile. The results indicated that the growth characteristics of microcolonies were encoded in their morphologies which correlated to the characteristic diffraction patterns. Proposed methodology was able to classify three genera based on comprehensive phenotypic map which incorporated growth speed, ring count, and colony diameter. While the proposed method illustrated the possibility of discriminating microcolonies in their early growth stage, more thorough biophysical understanding is needed to expand the technology to other species. Biotechnol. Bioeng. 2011; 108:637–644. © 2010 Wiley Periodicals, Inc.

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Section: Treatmentmentioning

confidence: 99%

Psychiatric disorders in advanced cancer

Miovic

Block

2007

Cancer

321

228

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“…Methylphenidate is a central nervous system stimulant approved by the US Food and Drug Administration (FDA) for the treatment of attention-deficit/hyperactivity disorder and narcolepsy (Sood, Barton, Loprinzi, 2006). Some studies have shown an increase in liver enzymes, and blood pressure alterations in older patients treated chronically with this drug (Hardy, 2009).…”

Section: · Psychostimulantsmentioning

confidence: 99%

Elderly and drugs: risks and necessity of rational use

Baldoni

Chequer

Ferraz

et al. 2010

Braz. J. Pharm. Sci.

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In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.Uniterms: Elderly/inappropriate medicines. Medicines/consumption. Medicines/adverse reaction. Medicines/intoxication. Medicine/rational use. Medicine/inappropriate prescribing.Durante as últimas décadas, o mundo passou por uma transformação demográfica, com um rápido crescimento da população idosa e, portanto, tanto a demanda para a manutenção da saúde deste grupo populacional, quanto o consumo de medicamentos estão aumentando. Ainda, as mudanças farmacocinéticas e farmacodinâmicas que ocorrem em idosos podem interferir diretamente nos efeitos adversos dos medicamentos e aumentar o risco de intoxicação. Além disso, há fatores externos que interferem na farmacoterapia dos idosos, tais como o uso inadequado e a falta de acesso à informação. Existem várias classes terapêuticas de medicamentos que devem ser utilizados com cautela ou evitados na população idosa, tais como antiinflamatórios, alguns anti-hipertensivos, diuréticos, digitálicos entre outros. Estes medicamentos, se não forem utilizados com cuidado, podem afetar a qualidade de vida e a segurança desta população. Assim, este trabalho visa identificar medicamentos que devem ser utilizados com cuidado em pacientes idosos para evitar intoxicações e/ou eventos adversos aos medicamentos.Unitermos: Idosos/medicamentos inadequados. Medicamentos/consumo. Medicamentos/reação adversa. Intoxicação medicamentosa. Medicamentos/uso racional. Prescrição inapropriada.

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“…13,14 There is also a growing body of literature supporting the rapid treatment of depressive symptoms with intravenous (IV) ketamine. [15][16][17][18][19][20][21] A single case using IV ketamine to treat depression in a patient with advanced cancer has been reported.…”

Section: Introductionmentioning

confidence: 99%

Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care

Irwin

Iglewicz

2010

Journal of Palliative Medicine

105

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Depression is prevalent and undertreated in patients receiving hospice care. Standard antidepressants do not work rapidly or often enough to benefit most of these patients. Here, two cases are reported in which a single oral dose of ketamine provided rapid and moderately sustained symptom relief for both depression and anxiety. In addition, no adverse effects were noted. Further investigation with randomized, controlled clinical trials is necessary to firmly establish the effectiveness of oral ketamine for the treatment of depression and anxiety in patients receiving hospice care. Ketamine may be a promising safe, effective, and cost-effective rapid treatment for depression and anxiety in this population.

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Use of methylphenidate in patients with cancer

Cited by 60 publications

References 43 publications

Psychiatric disorders in advanced cancer

Psychiatric disorders in advanced cancer

Elderly and drugs: risks and necessity of rational use

Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care

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