Use of Mice in Testing of Antigenic Power of Tetanus Toxoid

Koerber, Walter L.; Mook, Gertrude E.

doi:10.3181/00379727-51-13946p

Cited by 2 publications

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“…The designation of an International Standard for Tetanus Toxoid (Adsorbed) (38) has provided a basis by which comparisons of the quantitatively assayed potency of tetanus toxoid within and between laboratories may be made, as well as comparisons of the human responses to toxoids of titrated unitage. The use of a quantitative test for tetanus toxoids was proposed more than 20 years ago (12,21,23), and such an assay has been used by a number of laboratories (3,9,13,14,15,18,29,33,34). The United States has continued to prescribe a qualitative test (U.S. Department of Health, Education and Welfare, Minimum Requirements: Tetanus Toxoids, December 15, 1952).…”

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Influence of Mouse Strain on the Assayed Potency (Unitage) of Tetanus Toxoid

Hardegree

Pittman

Maloney

1972

Applied Microbiology

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The assayed potency of an adsorbed tetanus toxoid C2, relative to the international standard for tetanus toxoid (adsorbed), varied significantly with the use of different strains of mice. The unitage was highest with NIH mice, and it was not significantly different from that with CFW mice. With CDF1 and BALB/c mice, however, the assayed potency was significantly lower than with NIH mice. C3H mice failed to respond to the dose range of the toxoids employed with the other four strains. The significance of the influence of the mouse strain on the designation of a prescribed unit requirement for tetanus toxoid, adsorbed, relative to human efficacy is discussed.

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confidence: 99%