Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD)

Lascasas-Porto, Carmen Lucia; Milhomens, Ana Letícia M.; Virgini-Magalhães, Carlos Eduardo; Fernandes, Fabiano F.A.; Sicuro, Fernando Lencastre

doi:10.1016/j.mvr.2008.02.002

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…This activity means that Ruscus aculeatus L. considerably benefits patients with venous disease, including peripheral venous disease (PVD) and hemorrhoidal disease. An extract of Ruscus aculeatus L. has been found to significantly decrease the diameter of the popliteal and femoral veins in patients with primary varicose veins in the standing position after 2 h and 1 week, respectively, even though no such result has been observed while supine, and blood flow velocity was significantly quicker [60]. Patients with PVD presenting with the main symptoms of leg edema and the sensation of heavy legs reported they had ameliorated after taking Ruscus aculeatus L. extract [61].…”

Section: Ruscus Aculeatus Lmentioning

confidence: 93%

“…It appears that the venotonic activity is due to the stimulation of norepinephrine release from postganglionic terminals and the activation of alpha-1/2 adrenergic receptors in venular/venous smooth muscle [56,59]. The endothelium is apparently of no particular relevance for this venotonic activity [60]. This activity means that Ruscus aculeatus L. considerably benefits patients with venous disease, including peripheral venous disease (PVD) and hemorrhoidal disease.…”

Section: Ruscus Aculeatus Lmentioning

confidence: 99%

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The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Raposo

Saraiva

Ramos

et al. 2021

Biology

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(1) Background: Cardiovascular disease (CVD) is a major public health concern worldwide and a key cause of morbidity and mortality in developed countries. Accumulating evidence shows that several CVD forms are characterized by significant microcirculatory dysfunction, which may both cause and be caused by macrovascular disease, often preceding clinical manifestations by several years. Therefore, interest in exploring food supplements to prevent and restore microcirculation has grown. Given the continuous need to expand the available therapeutic arsenal for CVD, the food supplements market has recently grown and is expected to continue growing. (2) Methods: We provide an authoritative up-to-date comprehensive review of the impact of food supplementation on microcirculation by analyzing the European and American legal food supplements framework and the importance of food safety/food quality in this industry. We review the main literature about food bioactive compounds with a focus on microcirculation and some main food supplements with proven benefits. (3) Results: Despite a lack of scientific evidence, diet and microcirculatory function are clearly connected. The main food supplement examples in the literature with potential beneficial effects on microcirculation are: Ruscus aculeatus, Centella asiatica, Ginkgo biloba, Salvia miltiorrhiza, Crataegus spp., Ginseng, Mangifera indica, Aesculus hipocastanum, Hamamelis virginiana, and Vitis vinifera. (4) Conclusions: Further clinical trials are necessary to better explore the effects of these food supplements, particularly on humans.

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Section: Ruscus Aculeatus Lmentioning

confidence: 93%

Section: Ruscus Aculeatus Lmentioning

confidence: 99%

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Raposo

Saraiva

Ramos

et al. 2021

Biology

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“…It is a common observation that varicose veins do not fully collapse when the leg is elevated. The reasons for this may include a high outflow resistance, tricuspid regurgitation, or a reduction in the resistance of the microcirculation . The application of a stocking on an elevated leg may therefore not protect against the inadvertent displacement of foam, especially in patients with extensive varicose veins of the calf.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Changes at the Saphenofemoral Junction During the Application of a Below-Knee Graduated Compression Stocking

Lattimer

Azzam

Kalodiki

et al. 2012

Dermatologic Surgery

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“…Clinical evaluation Body weight 30,50,53,54 BMI 50,54 Arm, waist and hip circumference 50 Body composition 20,50 Food intake 50 Disease symptoms 19,30,48,[50][51][52][53] Effectiveness scale 51,59,60 Safety scale 59,60 Tolerance scale 60 Quality of life scale 18,58 Blood chemistry 19,30,48,[50][51][52][53] Venous and arterial structure and function Beta-n-acyl glucosaminadase 44 Arylsulfatase 44 Uronic acid 44 Endothelial progenitor cells 14 VCAM-I 47 ICAM-I 47 E-selectin 47 Macrocirculatory evaluation 43,57,59 Microcirculatory evaluation 41,56 Maximum venous outow 45 Flow-mediated brachial artery vasodilation 16,22,47 Flow-mediated endothelium-dependent vasodilation 14 Portal vein cross section…”

Section: Category Of Methods Methods (References)mentioning

confidence: 99%

Review of existing experimental approaches for the clinical evaluation of the benefits of plant food supplements on cardiovascular function

Meoni¹,

Restani²,

Mancama³

2013

Food Funct.

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We conducted a survey of the National Centre for Biotechnology Information (NCBI) PubMed database to identify methods most commonly used for the evaluation of the effect of plant food supplements on the cardiovascular system and their relevance to the regulatory status of these products. Particularly, our search strategy was aimed at the selection of studies concerning the clinical evaluation of the beneficial effects of the most commonly studied plant food supplements acting on the cardiovascular system. Following the screening of 3839 papers for inclusion criteria, 48 published reports were retained for this review. Most studies included in this review used a double blind controlled design, and evaluated the effect of plant food supplements on individuals affected by a disease of the cardiovascular system. The majority of the studies were found to be of low methodological quality on the Jadad scale, mainly because of inadequate reporting of adverse events and of patient withdrawals. In comparison, measures used for the evaluation of benefits included mostly cardiovascular risk factors as recommended in international guidelines and in accordance with principles laid down for the evaluation of health claims in food. The risk factors most frequently evaluated belonged to the category of "lipid function and levels", "heart function" and "blood pressure". For the absolute majority of the studies, the study period did not exceed one month. This review highlights critical factors to be considered in the design of studies evaluating the health effects of plant food supplements on the cardiovascular system. Between others, the inclusion of healthy individuals, better reporting and description of the characteristics of the product used could improve the quality and relevance of these studies.

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Use of microcirculatory parameters to evaluate clinical treatments of chronic venous disorder (CVD)

Cited by 10 publications

References 53 publications

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Hemodynamic Changes at the Saphenofemoral Junction During the Application of a Below-Knee Graduated Compression Stocking

Review of existing experimental approaches for the clinical evaluation of the benefits of plant food supplements on cardiovascular function

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