Use of minors as bone marrow donors: Current attitude and management

Chan, Ka Wah; Gajewski, James; Supkis, Daniel E.; Pentz, Rebecca D.; Champlin, Richard E.; Bleyer, W. Archie

doi:10.1016/s0022-3476(96)80129-6

Cited by 38 publications

(27 citation statements)

References 12 publications

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“…Children are usually excluded, but can be included as PBPC donors where necessary. Certainly, the use of minors as PBPC donors represents an ethical dilemma, 6 which from our point of view is no greater than that posed by bone marrow donation for a relative. Technical problems, 5 possible psychological impact of leukapheresis and ethical issues, have made reduction of the number of procedures desirable.…”

Section: Peripheral Blood Progenitor Cell (Pbpc) Collection By Large-mentioning

confidence: 97%

Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donors

González

Benito

Díaz

et al. 1999

Bone Marrow Transplant

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Section: Peripheral Blood Progenitor Cell (Pbpc) Collection By Large-mentioning

confidence: 97%

Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donors

González

Benito

Díaz

et al. 1999

Bone Marrow Transplant

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“…26 There was little agreement, however, on the management of large volume collections. Of 52 respondents, 6 would limit collections to 25% or less of the donor's blood volume, whereas 24 placed the limit at 50% or higher.…”

Section: Infants and Children As Donorsmentioning

confidence: 99%

Evaluation of Hematopoietic Stem Cell Donors

Horowitz¹,

Confer²

2005

Hematology

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Donation of hematopoietic stem cells, either through bone marrow or peripheral blood collection, is a generally safe procedure for healthy donors. Serious adverse events are uncommon and death is exceedingly rare. Nevertheless, all donors must be carefully evaluated and fully informed prior to donation. This should be done by clinicians having good understanding of the potential physical and psychological complications of donation and the factors that may increase these risks. Additionally, donors and graft products must be evaluated for the potential to transmit infections and other diseases to the recipient and to satisfy an increasing number of national and international regulatory requirements. Donors must be able to provide informed consent without coercion or pressure. Special attention to the clinical, psychological and social needs of pediatric donors is necessary.

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“…In a survey of marrow transplant physicians in pediatrics, only seven of 56 physicians would wait until the donor is older than 6 months of age, and only six of 52 responders would limit collections to 25% or less of the donor's blood volume, whereas 24 placed the limit at more than 50%. 20 The committee of Hematopoietic Stem Cell Transplantation of the Japanese Pediatric Hematology and Oncology Society recommends against harvesting marrow from donors less than 1 year old. It might be technically difficult to harvest BM from infant donors lacking bone maturation.…”

mentioning

confidence: 99%

Feasibility of marrow harvesting from pediatric sibling donors without hematopoietic growth factors and allotransfusion

Yabe

Morimoto

Shimizu

et al. 2014

Bone Marrow Transplant

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We retrospectively studied 108 marrow harvests from 105 pediatric sibling donors. The median age of donors was 8 years (range: 1-15) and the median body weight was 27 kg (range: 10-100). The volumes of aspirated marrow were 5.0-23.8 mL/kg donor body weight, and harvested bone marrow volume exceeded 15 mL/kg in 42% of the donors. A total of 100 autologous blood donations were performed, and eight donors had red cells salvaged from their harvests reinfused. The median Hb levels before and after harvests were 12.3 g/dL (range: 10.0-14.7) and 11.0 g/dL (range: 8.9-13.8), respectively. None of the donors received allogeneic blood transfusions or hematopoietic growth factors such as EPO and G-CSF before or after collection. Transplanted dose was 1.4-10.8 × 10 8 cells/kg recipient body weight without differences due to donor age. Higher concentrations of nucleated and CD34 + cells were obtained from younger donors. All donors tolerated the procedures well, with no serious complications. Thus, children may safely donate marrow for allogeneic transplantation, and the yields of nucleated cells for engraftment are substantial.Bone Marrow Transplantation (2014) 49, 921-926;

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Use of minors as bone marrow donors: Current attitude and management

Cited by 38 publications

References 12 publications

Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donors

Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donors

Evaluation of Hematopoietic Stem Cell Donors

Feasibility of marrow harvesting from pediatric sibling donors without hematopoietic growth factors and allotransfusion

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