Use of mitomycin c with conjunctival autograft in pterygium surgery in Asian-Canadians

Wong, Vincent; Law, Francis

doi:10.1016/s0161-6420(99)90445-1

Cited by 61 publications

(49 citation statements)

References 22 publications

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“…Autologous conjunctival grafting seems to be the best method, giving both a low recurrence rate and fewer side-effects (Kenyon et al 1985;Chen et al 1995;Prabhasawat et al 1997). Reported recurrence rates range widely, to as low as 2% (Tan et al 1997;Wong & Law 1999;Al Fayez 2002). The technique is considered to require a highly trained surgeon and the recurrence rate depends on surgical experience (Ti et al 2000).…”

Section: Introductionmentioning

confidence: 99%

The cut‐and‐paste method for primary pterygium surgery: long‐term follow‐up

Koranyi

Seregard

Kopp

2005

Acta Ophthalmologica Scandinavica

150

112

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ABSTRACT.Objective: To evaluate the recurrence rate, reoperation rate and side-effects of a novel technique for pterygium surgery. Design: Retrospective study. Participants: The study included 461 eyes of 381 patients operated for primary nasal pterygium by the same surgeon between 1994 and 2003 and followed for 23 ± 20 months (range 6-112 months). Methods: Autologous conjunctival grafts harvested at the superotemporal limbus were used to cover the sclera after pterygium excision. Using a retrospective chart review, the outcome after attaching the transplant to the sclera with a fibrin tissue adhesive (n = 325) was compared to the outcome after graft attachment using absorbable sutures (n = 136). Main outcome measures: Recurrence rate, reoperation rate and complications. Results: The recurrence rate was 5.3% in the glue group and 13.5% in the suture group (p = 0.01). The reoperation rates were 1.2% and 3.3%, respectively (p = 0.31). Complications, such as transient transplant oedema and persistent corneal epithelial defects, occurred equally in both groups. Conclusion: Using a fibrin tissue adhesive instead of sutures when attaching the conjunctival transplant in primary pterygium surgery results in a significantly lower recurrence rate.

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Section: Introductionmentioning

confidence: 99%

The cut‐and‐paste method for primary pterygium surgery: long‐term follow‐up

Koranyi

Seregard

Kopp

2005

Acta Ophthalmologica Scandinavica

150

112

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“…These features include recurrence following surgical excision, ultraviolet radiation as an etiologic factor, and common treatment modalities (antimetabolites, radiation). 2,3 The p53 gene controls the cell cycle, is involved in DNA repair and synthesis, cell differentiation and apoptosis. 4 Mutations in the p53 gene inactivate or alter its functions.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of p53 tumor suppressor gene in pterygia

Weinstein

Rosenthal

Zirkin

et al. 2002

Eye

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Purpose To assess p53 gene expression in pterygia with and without recurrence. The pathogenesis of pterygium has not yet been determined. The most widely recognized etiologic factor is ultraviolet radiation, which leads to degeneration of the conjunctiva. However, pterygium was recently found to have several tumor-like characteristics. The p53 gene is a common marker for neoplasia, and is known to control cell cycle, cell differentiation and apoptosis. In this study we examined the expression of the p53 gene in primary pterygia with and without recurrence, searching for the pathogenesis of this very common lesion and for a prognostic factor for recurrence. Methods Immunohistochemical staining using a monoclonal antibody to human p53 (DO-7) was performed on 13 consecutive patients with primary pterygia, four pterygia without recurrence and nine pterygia which recurred during a 12-month follow-up. As a control we used two specimens of normal conjunctiva. Results Seven of the 13 pterygia specimens (54%) were positive for abnormal p53 expression. There was no difference between the groups with and without recurrence. Two out of four pterygia (50%) without recurrence and five out of nine (55.5%) pterygia with recurrence were positive. No pathological staining was observed in the control specimens. Conclusions In this study, abnormal p53 expression was found in pterygial epithelium, suggesting that pterygium could be a result of uncontrolled cell proliferation, and not as a degenerative lesion. There seems to be no connection between abnormal p53 expression and recurrence.

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“…Conjunctival auto transplantation combined with adjunctive mitomycin C for primary and recurrent pterygium was reported in two previous studies, with a recurrence rate of 2% to 9% [17,19,20].…”

Section: Introductionmentioning

confidence: 92%