Use of Mometasone Furoate to Prevent Polyp Relapse After Endoscopic Sinus Surgery

Abstract

clinicaltrials.gov Identifier: NCT00731185.

Sinus Surgery and Delivery Method Influence the Effectiveness of Topical Corticosteroids for Chronic Rhinosinusitis: Systematic Review and Meta-Analysis

“…The study authors were contacted via e-mail for raw data in cases of missing data. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The analyses were based on intention to treat. For missing standard deviations, either 95% CIs, 23,31,32 standard error.…”

The use of Postoperative Topical Corticosteroids in Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis

“…Stjärne, et al 15 reported that subjects who underwent FESS and were treated with mometasone furoate nasal spray resulted in a significantly longer relapse-free period than placebo in both the intention to treat (ITT) and the per protocol data sets. 15 …”

“…24 One cohort study (n ϭ 32) 18 reported normal ACTH levels measured before and 1 hour after removal of corticosteroid-soaked packing gauze. 18 The reported adverse events from the included studies were blood-stained mucus, [22][23][24][25] mild epistaxis, 15,17,19 and nasal dryness. 22,23,26 …”

Evidence-Based Management of Nasal Polyposis by Intranasal Corticosteroids: From the Cause to the Clinic

“…Since the approval of MFNS in the US, a large, randomized, placebo-controlled double-blind multicenter trial found that MFNS prevented or prolonged the time to nasal polyp recurrence [86]. In this study, subjects who had undergone FESS to treat endoscopically verified bilateral NP were treated with MFNS 200 µg once daily or placebo.…”