Use of N-acetylcysteine in clinical toxicology

Flanagan, Robert J.; Meredith, T. J.

doi:10.1016/0002-9343(91)90296-a

Cited by 177 publications

(120 citation statements)

References 48 publications

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“…N-acetylcysteine (MW 163 ) is a sulfhydryl-containing antioxidant used clinically as an acute antidote to acetaminophen overdose and as a pulmonary mucolytic agent (10). N-acetylcysteine reacts nonspecifically with a wide variety of reactive oxidants, including free radicals and reactive oxygen intermediates.…”

Section: Muscle Preparationmentioning

confidence: 99%

“…The muscle was stimulated to contract electrically (40-55 mA, 0.2-ms pulses) and force production was measured. Function of the unfatigued muscle was assessed by measuring the forces produced during maximal voluntary contractions (MVC) of ankle dorsiflexor muscle groups and during electrical stimulation of tibialis anterior at 1,10,20,40,80, and 120 Hz (protocol 1). Fatigue was produced using repetitive tetanic stimulations at 10 Hz (protocol 1) or 40 Hz (protocol 2); intermittent stimulations subsequently were used to monitor recovery from fatigue.…”

mentioning

confidence: 99%

“…This study tested this relationship using an experimental design that differs from previous human studies in two aspects. First, rather than using chronic nutritional supplements, we pretreated subjects with the nonspecific antioxidant N-acetylcysteine (NAC)' (10) by intravenous infusion immediately before fatiguing exercise. Second, rather than using volitional exercise to induce peripheral fatigue, we electrically stimulated tibialis anterior to repetitively contract under quasi-isometric conditions.…”

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confidence: 99%

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N-acetylcysteine inhibits muscle fatigue in humans.

Reid¹,

Stokić²,

Koch³

et al. 1994

J. Clin. Invest.

276

243

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Acute muscular fatigue is associated with the development of oxidative stress in humans. Strenuous contraction increases free radical production by human limb muscle (1) and fatiguing exercise alters biochemical indices of oxidative stress including glutathione status (2, 3) and markers of lipid peroxidation (4, 5). Such biochemical changes can be inhibited by chronic supplementation with antioxidant vitamins (4, 5) but nutritional supplements have not improved exercise performance (6-9). Thus, experiments to date have not determined whether oxidative stress is a cause of muscular fatigue in humans or simply an effect.In order to establish a cause/effect relationship, it is critical to demonstrate that exogenous antioxidants inhibit the loss of mechanical function during fatigue. This study tested this relationship using an experimental design that differs from previous human studies in two aspects. First, rather than using chronic nutritional supplements, we pretreated subjects with the nonspecific antioxidant N-acetylcysteine (NAC)' (10) by intravenous infusion immediately before fatiguing exercise. Second, rather than using volitional exercise to induce peripheral fatigue, we electrically stimulated tibialis anterior to repetitively contract under quasi-isometric conditions. This technique was developed previously (11) to evoke peripheral fatigue in the absence of central neural processes (e.g., inhibitory reflexes, coordination, motivation, learning) that can importantly influence volitional

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Section: Muscle Preparationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

N-acetylcysteine inhibits muscle fatigue in humans.

Reid¹,

Stokić²,

Koch³

et al. 1994

J. Clin. Invest.

276

243

View full text Add to dashboard Cite

show abstract

“…N-acetylcysteine (NAC) is one such antioxidant [28,44]. In clinical practice, NAC is used primarily to reduce hepatocyte injury after acetaminophen overdose [14,42]. NAC also has been used as nephroprotective prophylaxis before administration of radiographic intravenous contrast in patients with renal impairment [52].…”

Section: Introductionmentioning

confidence: 99%

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

Kearns

O’Briain

Sheehan

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…NAC (N-acetyl cysteine) is frequently used as a mucolitic and as an antidote in paracetamol intoxication [10][11] . NAC may maintain cell integrity by increasing the amount of glutathione within the cell or coming into direct reaction with spontaneous conjugation and/or reduction [12] . Recently, some studies have shown good results and absence of side effects in patients treated with interferon and NAS in chronic hepatitis C patients [13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

N-acetyl cysteine therapy in acute viral hepatitis

Gündüz

Karabay²,

Tamer³

et al. 2003

WJG

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AIM:To investigate the effect of N-acetyl cysteine (NAC) on acute viral hepatitis (AVH). METHODS:We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group. All patients were hospitalized and diagnosed as AVH. Blood total and direct bilirubin, ALT, AST, alkaline phosphatese, albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl, ALT level under 100 U/L, follow up was continued and then the patients were discharged. RESULTS:A total of 41(13 female and 28 male) AVH patients were included in our study. The period for normalization of ALT and total bilirubin in the study group was 19.7±6.9 days and 13.7±8.5 days respectively. In the control group it was 20.4±6.5 days and 16.9±7.8 days respectively (P>0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.

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Use of N-acetylcysteine in clinical toxicology

Cited by 177 publications

References 48 publications

N-acetylcysteine inhibits muscle fatigue in humans.

N-acetylcysteine inhibits muscle fatigue in humans.

N-acetylcysteine Protects Striated Muscle in a Model of Compartment Syndrome

N-acetyl cysteine therapy in acute viral hepatitis

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