Use of Naïve Bayes Classifier to Assess the Effects of Antipsychotic Agents on Brain Electrical Activity Parameters in Rats

Sysoev, Yu. I.; Shits, D. D.; Puchik, M. M.; Prikhodko, Veronika A.; Idiyatullin, R. D.; Kotelnikova, A. A.; Оковитый, С. В.

doi:10.1134/s0022093022040160

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…Rats of the control group were injected with 0.5 mL saline. Phenazepam (Novosibkhimfarm), was administered as a solution of the same volume, at a concentration of 1 mg/kg [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…The exposure time after the administration of the drug was 20 min, after which the rat was placed in the arena of the experimental field. This waiting time was chosen in accordance with our previously published paper [ 17 ]. In this article, we observed that administration of phenazepam at the dose of 1 mg/kg cause pronounced EEG changes in rats 20 min after the injection.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we chose rats medicated by phenazepam to model such a condition. Phenazepam is a well-known tranquilizer of the benzodiazepine group, with pronounced anticonvulsant, muscle relaxant and hypnotic effects [ 14 , 15 , 16 , 17 ]. The mechanism of action of phenazepam is to facilitate the inhibitory action of gamma-aminobutyric acid (GABA) on the transmission of action potentials in the central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

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Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test

et al. 2023

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One of the most important tasks in neuroscience is the search for theoretical foundations for the development of methods for diagnosing and treating neurological pathology, and for assessing the effect of pharmacological drugs on the nervous system. Specific behavioral changes associated with exposure to systemic influences have been invisible to the human eye for a long time. A similar pattern of changes is characteristic of phenazepam, a drug with a wide range of effects on the brain. In this study, we used a color-coding method, which consists of combining three time positions in one image, the present (0 s), the near future (0.33 s) and the far future (1.6 s). This method made it possible to identify movement patterns, such as the initialization of ahead movements, side turns and 180° turns (back), and also to determine the degree of predictability of future movements. The obtained data revealed a decrease in the number of turns to the sides while maintaining ahead movement, as well as an increase in the predictability of movements in rats under the influence of phenazepam. Thus, sedative doses of phenazepam do not exhibit general depression of brain functions, but the inhibition of specific centers, including the medial prefrontal cortex and postsubiculum, which are involved in stereotypic locomotive behavior.

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“…Rats of the control group were injected with 0.5 mL saline. Phenazepam (Novosibkhimfarm), was administered as a solution of the same volume, at a concentration of 1 mg/kg [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%