Use of National Health Service General Practice Records in Epidemiological Inquiries: Duodenal Ulcer--a Test Case

Sklaroff, Stanley A.

doi:10.1136/jech.17.4.177

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…That duodenal ulceration has a familial tendency has been well recorded in the literature (Doll and Buch, 1950;Doll and Kellock, 1951;Kuenssberg, 1962;Sklaroff, 1963;Vesel' et al, 1968;Gillies and Skyring, 1969;Kubickov'a and Vesely, 1972). Our study shows that the early onset patients have a significantly higher frequency of and stronger family history of ulcer dyspepsia (Table 5).…”

Section: Discussionmentioning

confidence: 78%

Duodenal ulcers: early and late onset.

Lam¹,

Ong²

1976

Gut

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SUMMARY A hospital series of 1042 duodenal ulcer patients was examined to determine the relationship of the age of onset of ulcer dyspepsia with the blood group and with the family history of ulcer dyspepsia. It was found that those patients whose symptoms begin in the first two decades of life (early onset patients) contain a significantly larger proportion of group A, B, and AB subjects and a significantly stronger family history of dyspepsia than those whose symptoms begin from the fourth decade of life onwards (late onset patients), in whom blood group 0 prevails. The group 0 status is shown to be associated with a significant proneness to duodenal ulceration and a significant proneness to bleed, and in the late onset patients a significant proneness to bleed recurrently and severely. Bleeding is the predominent complication in the early onset patients. There is a significantly increased tendency for the late onset ulcers to perforate, to become stenosed, to have severe pain, and to be virulent-that is, to be multiple, post-bulbar, or giant. While these features do not appear to be related to the effect of ageing, the occurrence of associated gastric ulceration and the mortality rate was shown to be related.

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Section: Discussionmentioning

confidence: 78%

Duodenal ulcers: early and late onset.

Lam¹,

Ong²

1976

Gut

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“…They reflect the capacity of this method to study disease, its diagnosis, management, and outcome in environments differing in size from a single practice to a collaborating group of 38 practices. The range of clinical subjects varies from the definition of disablement drawn from 7000 records in 38 practices (91) to the diminishing incidence and prevalence of duodenal ulcer and its association with psychiatric disorder and chronic pulmonary disease derived from a practice population of 13,131 registered patients in Scotland (92). Hypertension, its diagnosis, management and control also figure promi nently (93,94) .…”

Section: Clinical Studiesmentioning

confidence: 99%

Practice-Based Recording as an Epidemiological Tool

WOOD¹

1986

Annual Review of Public Health

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Health care in the United States during the last 40 years has evolved in response to the burgeoning growth of new medical information. Prior to World War II, the majority of physicians were generalists and some, because of special interests, training or experience, developed expertise in some arena, but the needs of most communities were met by physicians who were prepared to be ubiquitous in their responsibilities.After World War II, with the establishment of the National Institutes of Health (NIH) in the US and the concomitant increase in the availability of research funds from the federal government, research effort and , with it, educational activity in these areas increased. Subspecialty training programs in medical schools increased in number and size and by the early 1960s the majority of medical school graduates were entering subspecialty residency training programs. This movement had profound effects . Research was con centrated in hospitaVlaboratory settings. These were usually provided by the larger university hospitals, and studies therein generally assumed the capacity to extrapolate to the universe of medical care, including that outside the hospital.If this assumption was appropriate in individual case studies, it was less so in inquiries that described the incidence and prevalence of morbidity in hospital practice. Discussions on the preferred management for specific conditions if

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Section: Clinical Studiesmentioning

confidence: 99%