Use of natural products in anticytokine therapy

Gorchakova, T.V.; Suprun, I. V.; Sobenin, Igor A.; Orekhov, Alexander N.

doi:10.1007/s10517-007-0099-6

Cited by 17 publications

(9 citation statements)

References 10 publications

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“…In the same work we demonstrated that the composition of lipophilic extract was not altered by gastric digestion. Accordingly, two studies were performed both in vivo [ 5 ] and ex vivo [ 31 ] and revealed that marigold extracts could exert the anti-inflammatory effect even after oral administration. In fact, the consumption of extracts from marigold flowers led to a decrease in plasmatic proinflammatory cytokines (TNF- α and IL-1 β ), indicating a stability of the anti-inflammatory components through stomach passage [ 5 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

A Bio-Guided Fractionation to Assess the Inhibitory Activity ofCalendula officinalisL. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells

Colombo

Sangiovanni

D’Ambrosio

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Calendula officinalis L. has been largely known for its topical anti-inflammatory properties; however, there are no experimental evidences about its antiphlogistic effect at the gastric level. To investigate whether marigold might exert an activity against gastric inflammation, a CH2Cl2 extract obtained from C. officinalis flowers was evaluated in vitro on the NF-κB pathway. The lipophilic extract demonstrated a significant inhibitory effect on the NF-κB driven transcription. The identification of active compounds was conducted by a bio-guided fractionation of the extract that afforded 16 fractions. Fraction J exhibited a concentration-dependent inhibitory activity on the NF-κB driven transcription and significantly contributed to the antiphlogistic effect showed by CH2Cl2 extract. The main components of fraction J were loliolide and the fucoside acetates of β-eudesmol and viridiflorol. HPLC analysis of fractions D and E led to the identification and isolation of triterpene esters that showed a concentration-dependent inhibition of the NF-κB driven transcription, with faradiol-3-myristate and the corresponding aglycone being the most active compounds. The present study provides some experimental evidences that Calendula officinalis L. may exert an anti-inflammatory activity on the gastric district by the inhibition of the NF-κB system, identifying the compounds responsible, at least in part, for the observed effect.

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Section: Resultsmentioning

confidence: 99%

A Bio-Guided Fractionation to Assess the Inhibitory Activity ofCalendula officinalisL. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells

Colombo

Sangiovanni

D’Ambrosio

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Almost all parts of Sambucus has been utilised such as berries, leaves, flowers and barks. It has been reported that Sambucus is bioactive-rich compounds such as flavonoids and polyphenols which possess a broad spectrum of biological properties including antioxidant, anti-viral, and anti-cancer ( Gorchakova et al . 2007 ; Barak et al .…”

Section: Discussionmentioning

confidence: 99%

Assessing the Immunomodulatory Activity of Ethanol Extract of Sambucus javanica Berries and Leaves in Chloramphenicol-Induced Aplastic Anemia Mouse Model

Putra

Rifa’i

2020

TLSR

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Aplastic anemia, life-threatened disease, is a hematologic disorder characterised by bone marrow hypoplasia. Multiple modalities such as bone marrow transplantation and immunosuppression treatment have been proposed to ameliorate this entity, however it remains ineffective. Sambucus , a group of herb plants, possesses a broad spectrum of medicinal properties such as antioxidant, insulin-like activity, anticancer and antiviral. However, the study about its activity toward aplastic anemia incidence is based on limited data. Thus, the research aim of this study was to evaluate the immunomodulatory activities of Sambucus javanica in chloramphenicol-induced anemia aplastic mouse model. In this present study, BALB/c mice were administrated with chloramphenicol (CMP) to induce aplastic anemia then followed by S. javanica extracts treatment. Additionally, cellular and molecular aspects were evaluated by flow cytometry and Hematoxylin-Eosin staining. Further analysis showed that S. javanica extracts could promote the population number of regulatory T-cells and naive cytotoxic T-cells. Moreover, those extract also reduced the inflammation and necrotic incidence in CMP-induced mouse aplastic anemia model. Together, these results suggest that S. javanica has therapeutically effect to aplastic anemia by altering the immune system as an immunomodulatory agent.

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“…Several natural compounds, such as calendula (Calendula officinalis), elder (Sambucus nigra) and violet (Viola sp. ), were demonstrated to possess not only anti-inflammatory, but also antiatherosclerotic effects [81][82][83]. The combination of these herbs was used for the development of a novel dietary supplement (Inflaminat, INAT-Farma, Russia) [84].…”

Section: Clinical Studiesmentioning

confidence: 99%

Intracellular Cholesterol Lowering as Novel Target for Anti‐Atherosclerotic Therapy

Orekhov¹,

Ivanova²

2016

Cholesterol Lowering Therapies and Drugs

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Atherosclerosis and disorders associated with cardiovascular system remain the major problem of modern medicine and the leading cause of mortality in developed countries. According to the current knowledge, atherosclerosis development can begin early in life. Clinically silent early-stage lesions can be detected in a large population of young adults. Despite substantial progress in the recent years, therapy of atherosclerosis mostly remains limited to plasma lipid profile correction. Moreover, no therapy is currently available for the treatment of asymptomatic early stages of the disease. The existing synthetic drugs could not be used for this purpose, because of the unfavourable risk/benefit ratio and high cost of treatment, which has to be long-lasting. In this regard, medications based on natural agents with anti-atherosclerotic activity may offer interesting possibilities. Current research should focus on detection and evaluation of such agents. One of the important tools for anti-atherosclerotic drug evaluation is a cellbased model, which allows measurement of intracellular lipid accumulation. Antiatherosclerotic activity of various substances can therefore be evaluated by the decrease of intracellular lipid storage. In this chapter, we will discuss the development and application of cellular models based on primary culture of human arterial wall cells that are suitable for detection and measurement of anti-atherosclerotic activity of various substances. Using these models, several natural agents have been successfully evaluated, which led to the development of pharmaceutical products with antiatherosclerotic activity based on botanicals.

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Use of natural products in anticytokine therapy

Cited by 17 publications

References 10 publications

A Bio-Guided Fractionation to Assess the Inhibitory Activity ofCalendula officinalisL. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells

A Bio-Guided Fractionation to Assess the Inhibitory Activity ofCalendula officinalisL. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells

Assessing the Immunomodulatory Activity of Ethanol Extract of Sambucus javanica Berries and Leaves in Chloramphenicol-Induced Aplastic Anemia Mouse Model

Intracellular Cholesterol Lowering as Novel Target for Anti‐Atherosclerotic Therapy

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