Use of natural products in the crop protection industry

Hüter, Ottmar

doi:10.1007/s11101-010-9168-y

Cited by 76 publications

(42 citation statements)

References 33 publications

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“…They could be characterized by high biological activity, novel target sites and alternative MOA, low or no toxicity, high biodegradability compared to the commercial herbicides, and consequently an increased environmental and health safety. 7 Until now, natural products have not played an important role in herbicide development compared to other pesticides, 8,9 although some natural-like compounds with herbicidal activity have been developed. [10][11][12][13][14][15][16][17][18] In this paper, benzofuran-2-acetic esters are presented as a new class of 'bio-inspired' potential herbicides.…”

Section: Introductionmentioning

confidence: 99%

Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides

Araniti

Mancuso

Lupini

et al. 2019

Pest Management Science

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BACKGROUND In recent decades, the use of synthetic herbicides has been increasing, mainly in emerging countries. However, their intensive and indiscriminate application is a major cause of environmental pollution and human health injury. Therefore, there is an increasing need to develop new herbicides with safer toxicological and environmental profiles. A promising strategy is to synthesize new molecules containing the core of natural products as a template for the production of ‘bio‐inspired’ or ‘natural‐like’ herbicides. RESULTS The potential herbicidal activity of some benzofuran‐2‐acetic esters was assessed in vitro on Arabidopsis thaliana, a model species. All five molecules (M1‐M5) showed significant phytotoxic activity, reducing both shoot and root system at low concentrations. In particular, methyl 2‐(5‐methoxybenzofuran‐2‐yl)hexanoate (M3) exhibited the highest phytotoxicity displayed against two crops and weeds, monocots (Zea mays L. and E. crus‐galli) and dicots (Lactuca sativa L. and Amaranthus retroflexus L.). The M3 activity was also compared with glyphosate, a common herbicide, showing a lower but similar activity. Moreover, the results evidenced that M3 was more effective in post‐emergency. CONCLUSION Readily synthesizable benzofuran‐2‐acetic esters possessing the benzofuran ring as ‘bio‐inspired’ core, show significant herbicidal activity making them very efficient even at low concentrations. They can be sprayed in liquid form, and the addition of adjuvants can improve penetration through the leaf cuticle. These results confirm the importance of these molecules as models for the development of new natural‐like herbicides. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides

Araniti

Mancuso

Lupini

et al. 2019

Pest Management Science

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“…이들 제초제는 시판된 제초제 중의 아주 적은 부분을 차지하지만 여러 분 자작용점에 작용한다. 아직까지 다른 생물농약에 비하여 잡초관리 분야에서 천 연물질에 기초한 생물제초제의 발견은 가장 성공확률이 낮 은 것으로 알려져 있다 (Huter, 2011). 하지만 유기합성 제 초제에 의한 인체 및 환경에 대한 위해성논란 및 저항성 잡초의 출현을 방지할 수 있는 새로운 작용점에 대한 분자 생리학적 이해의 폭을 넓혀갈 수 있다는 측면에서 생물제 초제의 개발은 여전히 매력적이며 지속적으로 연구 개발 되어야 할 분야이다.…”

Section: 지속적 잡초관리는 유기농업과 관행농업을 위하여 주요 한 도전이 되고 있다 미래의 잡초관리는 종합적 잡초관리unclassified

Status and Perspective of Bioherbicde Development for Organic Weed Management

Pyon¹,

Lee²,

Park³

2017

Weed & Turfgrass Science

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ABSTRACT. Weed management under organic farming systems is very problematic since organic agriculture does not allow synthetic herbicides. Bioherbicide is needed to develop for weed management in organic agriculture systems. This review covers current status and perspectives of bioherbicide development for effective nonchemical weed management in organic farming systems. Bioherbicides are products of natural origin derived from living organisms, and more specifically bacteria, fungus and plants including natural metabolites for weed control. Bioherbicides derived from microorganisms or natural molecules are currently available on the pesticide markets. Devine, Lockdown (Collego), BioMal, Camperico, Organo-Sol and Opportune were derived from bacteria, Woad Warrior, Smolder, Mygogen, Chontrol Paste, Starritor and Phoma derived from fungus, and Katoun (pelargonic acid) and Beloukha were derived from plants. Corn gluten meal products and plant essential oils products are also available for nonselective weed control in organic agriculture. Organic weed management methods may be more feasible in small scale farming and high-value crops, and bioherbicides may be applied with other weed control practices in organic farming systems.

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“…Previous trials have also tested HPPD inhibitors for the treatment of Parkinsonʼs disease [5], thus enlarging the spectrum of action of the molecules with this property. As far as we know, very little information about plant-derived products showing HPPD inhibitory activity has been found in the literature [6][7][8][9], even when the starting point for the synthesis of NTBC, a herbicide which is also used as the therapy of choice for the treatment of TH1 [3], was the natural β-triketone, leptospermone [10]. The search for alternative HPPD inhibitors obtained from plants thus seems well worth investigating.…”

Section: Abstract !mentioning

confidence: 99%

The Inhibitory Activity of Plants from Central Argentina on p-Hydroxyphenylpyruvate Dioxygenase. Isolation and Mechanism of Inhibition of a Flavanone from Flourensia oolepis

et al. 2015

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The enzyme 4-hydroxyphenylpyruvate dioxygenase catalyzes the second step in the tyrosine degradation pathway. In mammals, this enzyme is the molecular target of drugs used for the treatment of metabolic disorders associated with defects in the tyrosine catabolism, mainly the fatal hereditary disease tyrosinemia type 1. This study evaluated the inhibitory effect of 91 extracts on 4-hydroxyphenylpyruvate dioxygenase from mostly native plants from central Argentina. Flourensia oolepis ethanol extract showed itself to be the most effective, and bioguided fractionation yielded pinocembrin (1) as its active principle. This flavanone, with an IC50 value of 73.1 µM and a KI of 13.7 µM, behaved as a reversible inhibitor of the enzyme and as a noncompetitive inhibitor. Molecular modeling studies confirmed the inhibitory potency of 1 and explained its activity by means of in silico determination of its binding mode in comparison to inhibitors of known activity, cocrystallized with 4-hydroxyphenylpyruvate dioxygenase. The main structural determinants that confer its potency are discussed. Analysis of the binding mode of the flavanone 1 with 4-hydroxyphenylpyruvate dioxygenase revealed the basis of the noncompetitive reversible mechanism of inhibition at the molecular level, which seems to be a common feature in this ubiquitous family of natural compounds. The resulting information may establish the basis for obtaining novel 4-hydroxyphenylpyruvate dioxygenase inhibitors for the treatment of tyrosinemia type 1 and other disorders associated with tyrosinase catabolism.

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Use of natural products in the crop protection industry

Abstract: Nature is a rich source of compounds exhibiting biological activity against weeds, plant diseases, insects and mites.

Cited by 76 publications

References 33 publications

Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides

Benzofuran‐2‐acetic esters as a new class of natural‐like herbicides

Status and Perspective of Bioherbicde Development for Organic Weed Management

The Inhibitory Activity of Plants from Central Argentina on p-Hydroxyphenylpyruvate Dioxygenase. Isolation and Mechanism of Inhibition of a Flavanone from Flourensia oolepis

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