Use of Near Infrared Spectroscopy to Estimate Cerebral Blood Flow in Conscious and Anaesthetized Adult Subjects

Owen-Reece, H; Elwell, Clare E.; Harkness, William; Goldstone, J; Delpy, DT; Wyatt, John; Smith, Martin; Matjasko, M. Jane

doi:10.1097/00132586-199612000-00014

Cited by 14 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we did not attempt to estimate cerebral blood flow and cerebral blood volume as described by Owen-Reece. 26 Our previous report showed that PGE 1 increased regional cerebral oxygenation state, but in this study PGEt it did not. This discrepancy might be attributed to the different algorithms of the equipment.…”

Section: Discussioncontrasting

confidence: 65%

Cerebral oxygénation during prostaglandin E1 induced hypotension

et al. 1998

View full text Add to dashboard Cite

Purpose: To evaluate the cerebral oxygenation effects of hypotension induced by prostaglandin E t(PGEI) during fentanyl-oxygen anaesthesia. Methods: Ten patients who underwent elective cardiac surgery received infusion of PGE I . After measuring the baseline arterial, mixed venous and internal jugular vein blood gases, systemic haemodynamics, and regional cerebral oxygen saturation (rSO2) estimated by INVOS 3100 R, PGE, was continuously infused at 0.25-0.65 ~g'kg -*'min -t (mean dosage: 410 -+ 41.4 mg'kg -* -min -*) intravenously. Ten, 20 and 30 minutes after the start of drug infusions, blood gases described above were obtained simultaneously with the measurement of systemic haemodynamics and rSO 2. Thirty minutes from the start of drug infusions, administration of PGE, was stopped. The same parameters were measured again I 0, 30 minutes after the stop of drug infusion. Results: PGE, decreased mean arterial pressure (MAP) to approximately 70% of the baseline value (P < 0.05). PGE, increased mixed venous saturation, but in contrast did not effect internal jugular pressure, internal jugular oxygen saturation and rSO 2. Conclusions: These results suggest that PGE, is a suitable drug for induced hypotension because flow/metabolism coupling of brain and regional cerebral oxygenation were well maintained during hypotension.Objectif : l~valuer les effets de l'hypotension, induite par la prostaglandine E,(PGE~), sur l'oxygEnation c&Ebrale pendant l'anesthEsie avec fentanyl et oxygEne. M&hodes : Dix patients qui devaient subir une chirurgie cardiaque Elective ont re~u une perfusion de PGE i. Apt& avoir procEdE ~ la gazomEtrie art&ielle de base, ~ celle du sang veineux mEIE et ~ celle de la veine jugulaire interne, EvaluE rhEmodynamie systEmique et la saturation en oxygEne cErEbral regional (SO2r) par INVOS 3100R, la PGE, a EtE administrEe en perfusion intraveineuse continue ~ 0,25-0,65/~g'kg -l'min -l (dosage moyen : 410 +_ 41,4 ~g.min-i). Dix, 20 et 30 minutes apr& le debut des perfusions de medicaments, les gaz du sang dEj~ cites ont &6 obtenus simultanEment avec la mesure de l'hEmodynamie systEmique et laSOzr. Trente minutes aprEs le debut des perfusions, l'administration de la PGE I a EtE arr&Ee. Les m~mes paramEtres ont EtE mesurEs encore aprEs I0 et 30 minutes apr~s rarr& de la perfusion de medicament. R~sultats : La PGE i abaisse la tension art&ielle moyenne (TAM) ~. 70 % de sa valeur de base environ (P < 0,05). La PGE, augmente la saturation en oxygEne du sang veineux m~IE mais, au contraire, n'a pas d'effet sur la tension de la veine jugulaire interne, sur la saturation en oxygEne de cette veine et sur la SO2r. Conclusion : Ces rEsultats montrent que la PGE, est un medicament appropriE pour induire de l'hypotension parce que le couplage dEbit/mEtabolisme du cerveau et l'oxygEnation cEr~brale rEgionale ont EtE maintenus pendant l'hypotension.

show abstract

Section: Discussioncontrasting

confidence: 65%

Cerebral oxygénation during prostaglandin E1 induced hypotension

et al. 1998

View full text Add to dashboard Cite

show abstract

“…NIRS has been shown to be a useful non-invasive technique for monitoring cerebral oxygenation and haemodynamics in newborns [19,20] and adults [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of potential factors affecting the measurement of cerebrovascular reactivity by near-infrared spectroscopy

TOTARO¹,

BARATTELLI²,

Quaresima³

et al. 1998

Clinical Science

View full text Add to dashboard Cite

1.Near-infrared (IR) spectroscopy is based on the relative transparency of skin, skull and brain to the light in the near-IR region (700-1100 nm) and on the oxygen-dependent tissue absorption changes of haemoglobin.2. We evaluated the most relevant factors (reproducibility, venous return, age and sex) that might affect reliability of near-IR spectroscopy to test CO2 cerebrovascular reactivity.3.Thirty-four healthy volunteers were enrolled in the study. The protocol consisted of a 3-min baseline, a 3-min hypercapnia (5% CO2 in air) and a 2-min recovery. Transcranial Doppler sonography measurements were simultaneously performed. The CO2 reactivity test was repeated on 27 subjects after 1 h to assess reproducibility. CO2 reactivity was also evaluated at different body positions (supine, 35 degrees Trendelenburg and 35 degrees reverse Trendelenburg), and over a gradual increase of the inspired CO2.4. Changes in near-IR spectroscopy and transcranial Doppler sonography parameters were significantly correlated with variations of end-tidal CO2 (P<0.005). A significant correlation between the reactivity indexes of near-IR spectroscopy parameters and flow velocity was also found (P<0.01). A high reproducibility was also found for deoxyhaemoglobin (rI=0.76), oxyhaemoglobin (rI=0.68) and flow velocity (rI=0.60) reactivity indexes. No significant differences between the reactivity indexes of different body positions were found (P>0.05). The reactivity index of oxyhaemoglobin and deoxyhaemoglobin decreased (P<0.05) and increased (P<0.01) with age respectively.5. We found that near-IR spectroscopy is a reliable and reproducible method for the evaluation of cerebrovascular reactivity and might be considered, after appropriate validation, for the assessment of patients with cerebrovascular disease.

show abstract

“…For CBF measurements, the measured ICG tissue concentration curve is comprised of both cerebral and non-cerebral components that are highly correlated. Using tracer kinetic models to recover CBF from a contaminated curve would result in an underestimation of CBF Gora et al, 2002;Owen-Reece et al, 1996). Solutions to overcoming this challenge have been proposed, including more advanced instrumentation as well as analytical approaches, with the main goal of increasing sensitivity to cerebral components.…”

Section: Extra-cerebral Signal Contaminationmentioning

confidence: 99%