Use of neutrophil to lymphocyte ratio for predicting histopathological grade of canine mast cell tumours

Macfarlane, Michael; Macfarlane, Laura; Scase, T.; Parkin, Timothy; Morris, Joanna S.

doi:10.1136/vr.103650

Cited by 36 publications

(58 citation statements)

References 54 publications

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“…In a recent paper, NLR was significantly higher in dogs with STS than in those with benign soft tissue lesions, although the parameter was not predictive of tumour grade . In two further studies focusing on canine mast cell tumour, higher NLR was predictive of higher tumour grade and was correlated with poorer outcome in univariate analysis, although it was not confirmed as an independent prognostic factor for survival in multivariate analysis . Neutrophilia has also been linked with tumour‐associated systemic inflammatory response for different canine malignancies, such as oropharyngeal cancer and acute leukaemia .…”

Section: Discussionmentioning

confidence: 97%

“…In human medicine, higher values of pretreatment NLR have been correlated with poorer prognosis for several solid malignancies, including STS . The prognostic/diagnostic value of different leukocyte populations, such as neutrophils, lymphocytes, eosinophils, and monocytes, and their ratios has been explored in canine solid and lymphoproliferative neoplasms . In a recent paper, NLR was significantly higher in dogs with STS than in those with benign soft tissue lesions, although the parameter was not predictive of tumour grade .…”

Section: Discussionmentioning

confidence: 99%

“…A few papers have explored the prevalence of different leukocyte populations and T‐lymphocyte subsets in tumour‐bearing vs healthy dogs . Furthermore, leukocyte counts and ratios have been proposed as diagnostic and prognostic tools for dogs with lymphoma, osteosarcoma, mast cell tumours and STS . Yet, the prognostic impact of peripheral leukocyte counts and ratios, including NLR, has not been assessed in feline medicine.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Chiti

Martano

Ferrari

et al. 2019

Vet Comparative Oncology

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Local recurrence (LR) is the major concern in the treatment of feline injection‐site sarcoma (FISS). Pretreatment leukocyte counts and ratios have been reported as diagnostic and/or prognostic markers in human and canine oncology. The aim of this retrospective study was to explore the prognostic impact on LR and overall survival time (OST) of pretreatment neutrophil‐to‐lymphocyte ratio (NLR), white blood cell count (WBCC), neutrophil count (NC) and lymphocyte count (LC) in cats with surgically excised FISS. Eighty‐two cats with histologically confirmed FISS at first presentation, without distant metastases, and with available pretreatment haematological analyses were retrospectively enrolled. The correlation of NLR, WBCC, NC, LC with tumour variables and patient variables was explored. NLR was correlated with tumour size (P = .004), histological pattern of tumour growth (P = .024) and histotype (P = .029), while WBCC and NC were associated with ulceration (P = .007, P = .011) and pattern of growth (P = .028, P = .004). No significant relationships emerged between LC and any of the considered variables. The impact of NLR, WBCC, NC, LC on LR and OST was then estimated in univariate and multivariate analysis. In univariate analysis, NLR, WBCC and NC were significant prognostic factors for both LR and OST. NLR, WBCC and NC remained prognostic in multivariate analysis for LR but not for OST. When NLR, WBCC and NC were jointly analysed, WBCC was the marker with the greater impact on LR. Preoperative NLR, WBCC and NC may aid in identifying cats at higher risk of LR.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Chiti

Martano

Ferrari

et al. 2019

Vet Comparative Oncology

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“…This makes prognosticating for individual patients challenging. Many clinical aspects of canine cutaneous MCTs have been studied including tumour location, tumour volume, tumour growth rate, tumour stage and patient leukocyte ratios, but no single parameter adequately predicts clinical behavior …”

Section: Introductionmentioning

confidence: 99%

Patient and tumour factors influencing canine mast cell tumour histological grade and mitotic index

Reynolds

Thomson

O’Connell

et al. 2019

Vet Comparative Oncology

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The aim of this study was to identify patient and tumour factors most frequently associated with high histological grades of canine mast cell tumours (MCTs). Search criteria in a shared database of multiple Animal Referral Hospital locations within Australia generated 400 canine MCTs in 286 patients. Patient and tumour data were extrapolated and the association between a tumour being histologically high grade and patient and tumour factors, including: patient breed, patient gender and neuter status, patient age at MCT excision, tumour location and tumour size was assessed using univariate analysis. The study consisted of 90 (21.9%) tumours meeting histological high‐grade criteria. Shar peis were the most likely breed to have high grade MCTs, whereas the Pug and the Golden Retriever were the least likely breeds to develop high‐grade MCTs. No significant difference in risks could be established between the age at which the tumour was excised, or the gender and neuter status of patients. MCTs of the inguinal region were the most likely single location to be high grade. Tumour size did not influence the likelihood of a tumour being high grade or low grade. The results of this study suggest that patient and tumour factors may play a role in the histological grades of canine MCTs.

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“…[9][10][11] Other studies have evaluated factors such as renal disease, 7,8,[12][13][14][15][16][17][18] neutrophil-tolymphocyte ratio (NLR), [19][20][21][22][23][24] platelet-to-lymphocyte ratio (PLR), 23,24 and anemia, [25][26][27] which have negatively affected outcome. Several studies in veterinary oncology have evaluated NLR as a prognostic factor in dog, [28][29][30][31] but no studies, to the authors' knowledge, have evaluated NLR or PLR in dogs with MM. Additionally, factors such as anemia, neutropenia, thrombocytopenia, and abdominal involvement, have not been specifically evaluated for prognostic relevance in dogs with MM.…”

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confidence: 99%

Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs

Fernández

Chon

2018

Veterinary Internal Medicne

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BackgroundMultiple myeloma (MM) in dogs typically is treated with melphalan. A daily melphalan dosing schedule reportedly is well tolerated and associated with favorable outcome. Although anecdotally a pulse dose regimen has resulted in successful responses, little long‐term outcome and safety data is available regarding this dosing regimen for dogs with MM.Hypothesis/objectives(1) To compare outcome and adverse event profiles between pulse dose and daily dose melphalan schedules and (2) to report prognostic factors in dogs with MM treated with melphalan. We hypothesized that both protocols would have similar outcomes and tolerability.AnimalsThirty‐eight client‐owned dogs diagnosed with MM receiving pulse dose (n = 17) or daily dose (n = 21) melphalan.MethodsRetrospective cohort study assessing outcome and adverse events in dogs receiving either protocol. Risk factors were evaluated for their prognostic relevance.ResultsBoth regimens were well tolerated and similarly effective, with an overall median survival time of 930 days. Renal disease and neutrophil‐to‐lymphocyte ratio (NLR) were negative prognostic factors, whereas hypercalcemia and osteolytic lesions were not prognostic factors in this study population.Conclusions and Clinical ImportancePositive results support the use of either dosing regimen for the treatment of dogs with MM, and renal disease and NLR were negative prognostic factors. Prospective, controlled, and randomized studies are warranted to confirm these findings.

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Use of neutrophil to lymphocyte ratio for predicting histopathological grade of canine mast cell tumours

Cited by 36 publications

References 54 publications

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

Patient and tumour factors influencing canine mast cell tumour histological grade and mitotic index

Comparison of two melphalan protocols and evaluation of outcome and prognostic factors in multiple myeloma in dogs

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