Use of non‐insulin antidiabetic drugs in children and young adults – A Scandinavian drug utilization study from 2010–2019

Jensen, Helene K; Rasmussen, Lotte; Furu, Kari; Karlstad, Øystein; Linder, Marie; Cesta, Carolyn E.; Pottegård, Anton

doi:10.1111/bcp.14867

Brit J Clinical Pharma

2021

DOI: 10.1111/bcp.14867

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Use of non‐insulin antidiabetic drugs in children and young adults – A Scandinavian drug utilization study from 2010–2019

Helene K Jensen

Lotte Rasmussen

Kari Furu

et al.

Abstract: Knowledge on utilization patterns of non-insulin antidiabetic drugs in childhood and youth is limited. Therefore, we conducted a population-based drug utilization study using publicly available aggregate data on use of non-insulin antidiabetics from 2010 to 2019 in Scandinavia (Denmark, Norway and Sweden) in individuals aged up to 24 years. For each non-insulin antidiabetic drug, we calculated the annual prevalence

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Cited by 3 publications

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Early onset type 2 diabetes mellitus: an update

Strati,

Moustaki,

Psaltopoulou

et al. 2024

Endocrine

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The incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals (aged <40 years) have significantly increased in recent years, approximating two to threefold increase in the respective rates. Numerous risk factors including severe obesity, family history, ethnicity, maternal diabetes or gestational diabetes, and female sex contribute to a younger age of onset. In terms of pathogenesis, impaired insulin secretion is the key operating mechanism, alongside with ectopic adiposity-related insulin resistance. T2DM diagnosis in a young adult requires the exclusion of type 1 diabetes mellitus (T1DM), latent autoimmune diabetes of adults (LADA) and maturity-onset diabetes of the young (MODY). The establishment of such diagnosis is critical for prognosis, because early-onset T2DM is associated with rapid deterioration in pancreatic β-cell secretory function leading to earlier initiation of insulin therapy. Furthermore, mortality and lifetime risk of developing complications, especially microvascular, is increased in these patients compared to both later-onset T2DM and T1DM patients; also, the latter are often developed earlier in the course of disease. The management of early-onset T2DM follows the same guidelines as in later-onset T2DM; yet patients aged 18–39 years are underrepresented in the big clinical trials on which the development of guidelines is based. Finally, young people with T2DM face significant challenges associated with social determinants, which compromise their adherence to therapy and induce diabetes distress. Future research focusing on the pathogenesis of β-cell decline and complications, as well as on specific treatment shall lead to better understanding and management of early-onset T2DM.

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Early onset type 2 diabetes mellitus: an update

Strati,

Moustaki,

Psaltopoulou

et al. 2024

Endocrine

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Noninsulin Diabetes Medications in Hospitalized Children and Adolescents

Vakharia

2024

Critical Care Nursing Clinics of North America

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Treatment of type 2 diabetes in children: what are the specific considerations?

Grøndahl

Johannesen

Kristensen

et al. 2021

Expert Opinion on Pharmacotherapy

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Use of non‐insulin antidiabetic drugs in children and young adults – A Scandinavian drug utilization study from 2010–2019

Cited by 3 publications

References 22 publications

Early onset type 2 diabetes mellitus: an update

Early onset type 2 diabetes mellitus: an update

Noninsulin Diabetes Medications in Hospitalized Children and Adolescents

Treatment of type 2 diabetes in children: what are the specific considerations?

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