Use of non-ionizing electromagnetic fields for the treatment of cancer

Jimenez, Hugo; Blackman, Carl F.; Lesser, Glenn J.; Debinski, Waldemar; Chan, Michael D.; Sharma, Sambad; Watabe, Kounosuke; Lo, Hui-Wen; Thomas, Alexandra; Godwin, Dwayne W.; Blackstock, William; Mudry, Albert; Posey, James; O’Connor, Rodney; Brezovich, I; Bonin, Keith; Kim‐Shapiro, Daniel B.; Barbault, Alexandre; Pasche, Boris

doi:10.2741/4591

Cited by 25 publications

(7 citation statements)

References 39 publications

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“…During the final 2 h, cells from both groups (Mag and Sham) were treated with 11.0 mM of [U-13C]glucose (Millipore Sigma, Miamisburg, OH) in DMEM (supplemented with 10% FBS, 2.0 mM glutamine). After 2 hours of magnetic or sham stimulation, the medium was removed by aspiration, cells were washed with cold PBS buffer, trypsinized, cell pellets were snapfrozen in liquid nitrogen, and were stored at -80°C until further analysis by 1 For 1 H-decoupled 13 C NMR experiments, a power-gated sequence with a WALTZ-16 composite pulse (flip-angle = 30°) was used. A 90°pulse with a duration of 10 µs was used with 10,000 scans.…”

Section: Observation Of Caspase3/7 Activation In Gbmmentioning

confidence: 99%

“…Electromagnetic fields (EMF) are known to produce anticancer effects in vitro and in vivo ( 1 ). We have shown recently that spinning oscillating magnetic fields (sOMF) produced by rotating permanent magnets in a noninvasive magnetic stimulation device (Oncomagnetic Device), developed by us, rapidly kill patient derived glioblastoma (GBM) and non-small cell lung cancer cells in culture ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

et al. 2021

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Electromagnetic fields (EMF) raise intracellular levels of reactive oxygen species (ROS) that can be toxic to cancer cells. Because weak magnetic fields influence spin state pairing in redox-active radical electron pairs, we hypothesize that they disrupt electron flow in the mitochondrial electron transport chain (ETC). We tested this hypothesis by studying the effects of oscillating magnetic fields (sOMF) produced by a new noninvasive device involving permanent magnets spinning with specific frequency and timing patterns. We studied the effects of sOMF on ETC by measuring the consumption of oxygen (O2) by isolated rat liver mitochondria, normal human astrocytes, and several patient derived brain tumor cells, and O2 generation/consumption by plant cells with an O2 electrode. We also investigated glucose metabolism in tumor cells using 1H and 13C nuclear magnetic resonance and assessed mitochondrial alterations leading to cell death by using fluorescence microscopy with MitoTracker™ and a fluorescent probe for Caspase 3 activation. We show that sOMF of appropriate field strength, frequency, and on/off profiles completely arrest electron transport in isolated, respiring, rat liver mitochondria and patient derived glioblastoma (GBM), meningioma and diffuse intrinsic pontine glioma (DIPG) cells and can induce loss of mitochondrial integrity. These changes correlate with a decrease in mitochondrial carbon flux in cancer cells and with cancer cell death even in the non-dividing phase of the cell cycle. Our findings suggest that rotating magnetic fields could be therapeutically efficacious in brain cancers such as GBM and DIPG through selective disruption of the electron flow in immobile ETC complexes.

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Section: Observation Of Caspase3/7 Activation In Gbmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

et al. 2021

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“…This is the case of, e.g., untreatable brain tumors, because certain high-molecular weight and/or hydrophilic anti-cancer drugs cannot penetrate the blood–brain barrier or if all other therapeutic options (radiotherapy, chemotherapy, targeted antibodies, or other pharmacological treatments) cannot eliminate the malignant growth. There are different concepts45 (discussed in more detail below) using different frequencies of the EMF spectrum with or without signal modulation, to treat specific tumors, with electric (TTFields, electroporation) or EMFs (hyperthermia, RF treatment), or in combination with chemotherapeutics or nanoparticles (see also Table 2).…”

Section: Cancer Treatmentmentioning

confidence: 99%

<p>Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz</p>

Mattsson¹,

Simkó²

2019

MDER

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The potential for using non-ionizing electromagnetic fields (EMF; at frequencies from 0 Hz up to the THz range) for medical purposes has been of interest since many decades. A number of established and familiar methods are in use all over the world. This review, however, provides an overview of applications that already play some clinical role or are in earlier stages of development. The covered methods include modalities used for bone healing, cancer treatment, neurological conditions, and diathermy. In addition, certain other potential clinical areas are touched upon. Most of the reviewed technologies deal with therapy, whereas just a few diagnostic approaches are mentioned. None of the discussed methods are having such a strong impact in their field of use that they would be expected to replace conventional methods. Partly this is due to a knowledge base that lacks mechanistic explanations for EMF effects at low-intensity levels, which often are used in the applications. Thus, the possible optimal use of EMF approaches is restricted. Other reasons for the limited impact include a scarcity of well-performed randomized clinical trials that convincingly show the efficacy of the methods and that standardized user protocols are mostly lacking. Presently, it seems that some EMF-based methods can have a niche role in treatment and diagnostics of certain conditions, mostly as a complement to or in combination with other, more established, methods. Further development and a stronger impact of these technologies need a better understanding of the interaction mechanisms between EMF and biological systems at lower intensity levels. The importance of the different physical parameters of the EMF exposure needs also further investigations.

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“…Recently the WHO’s International Agency for Research on Cancer listed radio‐frequency electromagnetic fields (RF‐EMFs), ranging from 10 MHz to 300 GHz, as potentially carcinogenic (Baan et al, 2011). On the other hand, an increasing number of studies reported EMFs beneficial role in the treatment of numerous chronic diseases, such as cancer, mood disorders and many forms of neurodegeneration (Jimenez et al, 2018; Martiny et al, 2010; Wyszkowska et al, 2019), paving the way for the therapeutic use of magnetic‐field based techniques, such as Transcranial Magnetic Stimulation and Pulsed Electromagnetic Field (PEMF) stimulation (Hallett, 2000; Markov, 2007).…”

Section: Introductionmentioning

confidence: 99%

Thapsigargin blocks electromagnetic field‐elicited intracellular Ca²⁺ increase in HEK 293 cells

Bertagna

Lewis

Silva

et al. 2022

Physiological Reports

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The last decade experienced an exponential increase in the daily usage of electronic instruments, such as smartphones, laptops and wireless devices, producing a broad range of electromagnetic fields (EMFs) (IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, World Health Organization, and International Agency for Research on Cancer, 2002;Organization, W.H., 2007). This has led to higher intensities and prolonged exposure to users with respect to the electromagnetic radiation produced by these devices. Along with this, there is increasing interest in the biological impact of this exposure within the scientific community.Numerous investigations have reported an association between chronic exposure to extremely low frequency

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Use of non-ionizing electromagnetic fields for the treatment of cancer

Cited by 25 publications

References 39 publications

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

<p>Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz</p>

Thapsigargin blocks electromagnetic field‐elicited intracellular Ca²⁺ increase in HEK 293 cells

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Use of non-ionizing electromagnetic fields for the treatment of cancer

Cited by 25 publications

References 39 publications

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

<p>Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz</p>

Thapsigargin blocks electromagnetic field‐elicited intracellular Ca2+ increase in HEK 293 cells

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Thapsigargin blocks electromagnetic field‐elicited intracellular Ca²⁺ increase in HEK 293 cells