Use of Noncontact Infrared Skin Thermometer for Peripheral Arterial Disease Screening in Patients With and Without Diabetes

Hayashi, Akinori; Shichiri, Masayoshi

doi:10.1177/0003319720920162

Cited by 5 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the association between circulating serum growth differentiation factor (GDF) 15 and lower extremity atherosclerotic disease (LEAD) has been investigated in Chinese diabetes subjects [ 27 ]. Furthermore, Hayashi et al reported a method for accurate skin temperature measurement using noncontact, handheld infrared skin thermometer, which could serve as a new, cost-effective screening strategy for earlier diagnosis of PAD [ 28 ]. Very recently, Biscetti and colleagues reported that elevated plasma sortilin is significantly and independently associated with the presence of lower limb PAD in statin-free patients with diabetes, while omentin-1 is reduced in the same population.…”

Section: Discussionmentioning

confidence: 99%

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Feng

Sun

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background The prevalence of peripheral artery disease (PAD) is obviously increased in patients with diabetes. Existing evidence shows that cysteine-rich angiogenic inducer 61 (Cyr61), a 40-kD secreted protein, plays important roles in regulating cellular physiological processes. Recent studies have demonstrated a significant correlation between serum Cyr61 and atherosclerosis. However, the relationship between Cyr61 levels and PAD in patients with type 2 diabetes (T2DM) remains obscure. Methods Data from a total of 306 subjects with T2DM were cross-sectionally analysed. The extent of PAD was determined by using the Fontaine classification, which defines four stages. We measured serum Cyr61 concentrations by ELISA in subjects with and without PAD at Fontaine’s stage II, III, or IV. Logistic regression models were used to examine the independent association of Cyr61 with PAD. Results Out of the 306 subjects enrolled, 150 were free from PAD, while 156 had clinically significant PAD. In subjects with PAD, the prevalences of Fontaine classification stages II, III and IV were 48.7%, 32.1%, and 19.2%, respectively. Patients with more advanced PAD had significantly higher Cyr61 (P for trend < 0.001). The prevalence of PAD on the basis of severity increased with increasing Cyr61 quartiles (all P values for trends < 0.001), and the severity of PAD was positively correlated with Cyr61 quartiles (r = 0.227, P = 0.006). The association of Cyr61 levels with PAD remained after adjusting for major risk factors in a logistic regression analysis. Conclusions Our results demonstrated that Cyr61 was significantly increased in PAD patients with T2DM and that Cyr61 levels were positively associated with disease severity. Cyr61 could be a promising biomarker and further studies are needed to assess its clinical utility.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Feng

Sun

et al. 2020

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Lately, the association between circulating serum growth differentiation factor 15 (GDF15) and lower extremity atherosclerotic disease (LEAD) has been investigated in Chinese diabetes subjects [27]. Furthermore, Hayashi, A. et al reported a method for accurate skin temperature measurement using noncontact, handheld infrared skin thermometer, which could serve as a new, cost-effective screening strategy for earlier diagnosis of PAD [28]. In the present study, Cyr61 has potential clinical signi cance as a simple, easy-to-measure biochemical marker of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Association of serum Cyr61 levels with peripheral arterial disease in patients with type 2 diabetes

Feng

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The prevalence of peripheral artery disease (PAD) is obviously increased in diabetic patients. Existing evidences show that cysteine-rich angiogenic inducer 61 (Cyr61), a 40 kD secreted protein, plays important roles in regulating cellular physiological processes. Recent studies have demonstrated a significant correlation between serum Cyr61 levels and atherosclerosis. However, the relationship between Cyr61 levels and PAD in type 2 diabetic patients remains obscure.Methods:. A total of 306 subjects with type 2 diabetes were recruited. The extent of PAD was determined by using the Fontaine classification, which defines four stages. We analyzed Cyr61 serum levels by ELISA in patients with and without PAD at Fontaine’s stage II, III, or IV. Logistic regression models were used to examine the independent association of Cyr61 with PAD.Results: Out of the 306 patients enrolled in this study, 150 patients were free from PAD, while 156 had clinically significant PAD. In PAD patients, the prevalences of Fontaine classification stage II, III and IV were 48.7%, 32.1%, and 19.2%, respectively. Patients with more advanced PAD had significantly higher Cyr61 (P for trend <0.001). The prevalence of PAD on the basis of severity increased with ascending Cyr61 quartiles (all P for trend <0.001), and the severity of PAD was positively correlated with Cyr61 quartiles (r=0.227, P=0.006). The association of Cyr61 levels with PAD remained after adjusting for major risk factors in a logistic regression analysis.Conclusions: Our results demonstrated that Cyr61 was significantly increased in type 2 diabetic patients with PAD and that Cyr61 levels were positively associated with disease severity. It could be a promising biomarker and further studies are needed to assess its clinical utility.

show abstract

“…Previous studies used similar instruments to measure skin surface temperature7,8,12,13,30 and presented strong reliability (ICC = 0.92) and validity ( r = 0.97) using the intraclass correlation coefficient and Pearson correlation, respectively 30. Infrared thermometers are advantageous because of their faster performance and portability 31-34…”

Section: Methodsmentioning

confidence: 99%

“…30 Infrared thermometers are advantageous because of their faster performance and portability. [31][32][33][34]…”

Section: Temperature Measurementsmentioning

confidence: 99%

Comparison of Cryotherapy Performed With Ice or Gel and Superficial Skin Cooling of Older Women: A Randomized, Crossover, Clinical Trial

Fachin,

de Estéfani,

Marinho e Lima

et al. 2024

Journal of Geriatric Physical Therapy

View full text Add to dashboard Cite

Background and Purpose: Cryotherapy is an affordable and popular treatment of soft tissue injuries, which can reduce inflammation and pain. Studies have specifically addressed young adults and athletes, and these findings have been extended to older adults in clinical practice. Aging is associated with changes in the skin, including collagen degradation, decreased fat layer thickness, and reduced blood flow, which can alter the skin response to stress. Because of age-related changes, there are concerns about the direct use of ice on the skin of older individuals. Skin injuries were also observed after cryotherapy. This study aimed to assess the most effective and safe cryotherapy for superficial skin cooling among older women. Methods: Eighteen older women were enrolled in this blinded, randomized, crossover, clinical trial. The mean values (SD) of their age, height, and weight were 70.0 years (6.0), 156.0 cm (9.1), and 72.8 kg (19.5), respectively. The participants underwent cryotherapy using bagged ice, bagged ice plus a wet towel, or gel pack for 20 minutes. The surface temperature of the skin was measured at the end of a 20-minute cryotherapy session using an infrared thermometer. Repeated-measures analysis of variance was conducted to analyze the effect of cryotherapy modalities and time, as well as the interaction between these 2 factors. The secondary outcome was the presence of cryotherapy-induced lesions. Results and Discussion: Cryotherapy modalities had significant effects on superficial skin temperature (P = .001). Time points after application also had an effect (P = .0001), and no interaction was observed between cryotherapy modalities and time points (P = .051). Bonferroni post hoc evaluation showed that bagged ice (P = .008) and gel (P = .007) were more effective in decreasing the superficial skin temperature than bagged ice plus wet towel. No difference was observed between bagged ice and gel (P = .32). Three of the 18 patients experienced adverse effects with the gel pack. Conclusion: This study of older women found that ice and gel cooled the skin more effectively than ice wrapped in towels. However, the gel pack had some adverse effects. Therefore, bagged ice is recommended for cryotherapy in older women.

show abstract

Use of Noncontact Infrared Skin Thermometer for Peripheral Arterial Disease Screening in Patients With and Without Diabetes

Cited by 5 publications

References 33 publications

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes

Association of serum Cyr61 levels with peripheral arterial disease in patients with type 2 diabetes

Comparison of Cryotherapy Performed With Ice or Gel and Superficial Skin Cooling of Older Women: A Randomized, Crossover, Clinical Trial

Contact Info

Product

Resources

About