Use of Nonprescription Weight Loss Products

Blanck, Heidi M.; Khan, Laura Kettel; Serdula, Mary K.

doi:10.1001/jama.286.8.930

Cited by 138 publications

(68 citation statements)

References 20 publications

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“…Interestingly, 8% of women with no excess body weight were also reported to use such products. 54 Even though these preparations are popular, they frequently lack evidence of effectiveness 55 and some may be associated with severe adverse events. Three of the reviewed trials assessed adverse events [45][46][47] and all agree on the total absence of adverse events in participants receiving chromium picolinate.…”

Section: Discussionmentioning

confidence: 99%

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

2003

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The aim of this meta-analysis was to assess the evidence of chromium picolinate for reducing body weight. Literature searches were conducted on Medline, Embase, The Cochrane Library, Amed and Ciscom. Nine experts and four manufacturers of commercial preparations containing chromium picolinate were asked to contribute published and unpublished studies. There were no restrictions regarding the language of publication. The screening of studies, selection, data extraction, validation and the assessment of methodological quality were performed independently by two reviewers. To be included, studies were required to state that they were randomized, double-blind and placebo-controlled, and report on body weight. Ten trials met all inclusion criteria and provided data, which were suitable for statistical pooling. For body weight a significant differential effect was found in favour of chromium picolinate (weighted mean difference: À1.1 kg; 95% confidence interval (CI): À1.8 to À0.4 kg, n ¼ 489). Sensitivity analysis suggests that this effect is largely dependent on the results of a single trial (weighted mean difference: À0.9 kg; 95% CI: À2.0 to 0.2 kg, n ¼ 335). Three of the reviewed trials reported on adverse events, indicating their absence in the treatment groups. In conclusion, our meta-analysis suggests a relatively small effect of chromium picolinate compared with placebo for reducing body weight. The clinical relevance of the effect is debatable and the lack of robustness means that the result has to be interpreted with caution.

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Section: Discussionmentioning

confidence: 99%

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

2003

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Section: Resultsmentioning

confidence: 99%

“…[27,28] A small percentage of people who use these supplements inform their primary care providers or any health care professional. [27] Though these products are marketed as generally safe, this case and others in the literature suggest otherwise. We emphasize that clinicians routinely inquire about dietary supplement use during patient encounters and provide appropriate counsel on the potential for adverse outcomes especially in patients with sickle cell trait.…”

Section: Resultsmentioning

confidence: 99%

Severe non-exertional rhabdomyolysis from weight loss supplement in sickle cell trait: A perfect storm?

Olanipekun

Effoe

Adeogun

et al. 2018

CRIM

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Exertional rhabdomyolysis from sickle cell trait has been documented. Also, cases of rhabdomyolysis from the use of weight loss supplements in the setting of sickle cell trait and exertion have been described. However, the role of sickle cell trait in non-exertional rhabdomyolysis is not clear. We present a case of severe non-exertional rhabdomyolysis from weight loss supplement in a patient with sickle cell trait.A 45-year-old African American female with sickle cell trait presented to the emergency department with two days history of fatigue and mild breathlessness. She also reported diarrhea and vomiting for five days before presentation. She admitted to taking Garcinia cambogia (a dietary supplement) for weight loss one week prior to the onset of symptoms. She denied alcohol or drug use, rigorous physical activity or trauma.She was dehydrated on examination. Laboratory values revealed markedly elevated serum creatine phosphokinase (CPK) and creatinine levels. Garcinia cambogia was discontinued and she was hydrated with intravenous fluids. Her CPK and creatinine levels significantly trended down and she was discharged home with no apparent sequelae.Our patient had multiple episodes of diarrhea and vomiting likely from the use of Garcinia cambogia. We believe she suffered non-exertional rhabdomyolysis from dehydration in the setting of sickle cell trait. Though dietary weight loss supplements are marketed as generally safe, this case suggests otherwise. We emphasize that clinicians routinely inquire about use of these supplements and provide appropriate counseling to patients on the adverse effects, especially among those with sickle cell trait.

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“…Riesgos del consumo de suplementos dietéticos destinados para reducir de peso Los suplementos dietéticos no se recomiendan como parte de los programas destinados a reducir de peso, debido a que se desconoce su eficacia y seguridad 24 . Algunas revisiones efectuadas, han encontrado poca o inconcluyente evidencia de la efectividad de la mayoría de los ingredientes que forman parte de los suplementos destinados a la reducción de peso en corto tiempo (≤ 6 meses) y no se han encontrado estudios que evalúen sus efectos a largo plazo (≥ 12 meses) 10,25,26 .…”

Section: Suplementos Dietéticosunclassified

“…Esto concuerda con los hallazgos de Shekelle PG y cols 30 , que estudiaron píldoras para bajar de peso, las cuales contenían los estimulantes efedra y/o efedrina combinados con o sin cafeína, evidenciando mayores reducciones de peso versus el placebo, durante cuatro a seis meses de uso, pero quienes los utilizaron tuvieron dos a tres veces más riesgo de sufrir efectos adversos, como por ejemplo: problemas psiquiátricos, neurológicos, gastrointestinales y cardiacos. Otros estudios realizados en suplementos dietéticos que contienen estimulantes, han mostrado deficiencias en el control de calidad de sus productos (contaminación), con el consecuente efecto tóxico en las personas (reacciones alérgicas) 25 .…”

Section: Suplementos Dietéticosunclassified

Suplementos dietéticos para reducir de peso: dilemas médicos y éticos

Vásquez

López

2014

Rev. méd. Chile

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Use of Nonprescription Weight Loss Products

Abstract: With increasing rates of obesity, nonprescription product use is likely to increase. Clinicians should know about their patients' use of both prescription and nonprescription weight loss products.

Cited by 138 publications

References 20 publications

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

Severe non-exertional rhabdomyolysis from weight loss supplement in sickle cell trait: A perfect storm?

Suplementos dietéticos para reducir de peso: dilemas médicos y éticos

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