Use of Okra Mucilage and Chitosan Acetate in Verapamil Hydrochloride buccal patches development; In vitro and Ex vivo Characterization

Navamanisubramanian, Raja; Nerella, Raghunandan; Chamundeeswari, D.; Shanmuganathan, S

doi:10.5530/jyp.2017.9.18

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…The drug content was determined as mean of three determinations using standard calibration curve. Percentage moisture content was determined in triplicate for each batch since moisture in the film could be crucial as it affects the mechanical strength, adhesive properties, and friability of film [10].…”

Section: Drug Content and % Moisture Contentmentioning

confidence: 99%

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Formulation and Evaluation of Fast Dissolving Sublingual Film of Paroxetine Hydrochloride for Treatment of Depression

WADETWAR¹,

ALI²,

KANOJIYA³

2019

Asian J Pharm Clin Res

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Objective: Oromucosal route could be an alternative over the conventional route for paroxetine hydrochloride (PXH) as it offers direct systemic delivery, by avoiding extensive first-pass metabolism, which results in poor systemic absorption. The film dissolves quickly when placed in mouth without need of water thus helpful in providing rapid onset of action. Methods: Fast dissolving film of PXH was prepared using Pullulan in various combinations of 32 full factorial design by solvent casting technique. Prepared films were subjected to mechanical, in vitro, and ex vivo characterization. Results: The physicochemical characteristics such as mass uniformity, thickness, surface pH, and folding endurance were found satisfactory. The formulation (F3) containing 4% w/v Pullulan showed maximum release 94.31% and ex vivo permeation 92.67% through goat oral mucosa in 15 min. Uniform drug loading was observed in all the batches with disintegration time <25 s. Fourier transform infrared spectroscopy study revealed the compatibility of drug with polymer. Scanning electron microscopy revealed that there was uniform mixing of all ingredients. Optimized batch F3 was found to be stable for 1 month as no significant changes were observed in % cumulative drug release and weight of film. Conclusion: Pullulan a natural biodegradable polymer allocates good physical property to film. Hydrophilic nature of polymer imparts fast disintegrating property to film.

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Section: Drug Content and % Moisture Contentmentioning

confidence: 99%

“…The DT was noted for each film at which film started to break apart. All the studies were performed in triplicate for each batch [10].…”

Section: Disintegration Timementioning

confidence: 99%

Formulation and Evaluation of Fast Dissolving Sublingual Film of Paroxetine Hydrochloride for Treatment of Depression

WADETWAR¹,

ALI²,

KANOJIYA³

2019

Asian J Pharm Clin Res

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“…Studies that characterized okra mucilage have reported its physicochemical and rheological properties for pharmaceutical applications and its use as a natural additive in food products and nutraceutical supplements ( Figure 2 ) [ 74 , 75 , 76 , 77 , 78 ]. The main potential applications of okra polysaccharides in different industries are described below.…”

Section: Applications Of Okra Mucilagementioning

confidence: 99%

Okra (Abelmoschus esculentus L.) as a Potential Functional Food Source of Mucilage and Bioactive Compounds with Technological Applications and Health Benefits

Dantas

Buriti

Florentino

2021

Plants

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Abelmoschus esculentus has fruit popularly known as okra and belongs to the Malvaceae family. It is commonly used in cooking but also in traditional medicine in the treatment of worms, dysentery, inflammation, and also irritation of the stomach, intestines, and kidneys, as it is a potential functional food. Its mucilage is a highly viscous polysaccharide that is mostly composed of monosaccharides D-galactose, L-rhamnose, and galacturonic acid, as well as proteins and minerals. The functional properties of okra mucilage have been widely studied, mainly for its potential antidiabetic activity; thus, its use as adjuvant or nutraceutical therapy for diabetes is very promising. Due to its rheological properties, it is a potential resource for pharmaceutical and food applications. Okra mucilage can be extracted by several methods, which can directly influence its physicochemical characteristics and biological activity. Features such as low cost, non-toxicity, biocompatibility, and high availability in nature arouse the interest of researchers for the study of okra mucilage. The survey of research on the applications of okra mucilage highlights the importance of using this promising source of bioactive compounds with interesting technological properties. The potential of okra as a functional food, the properties of okra mucilage, and its technological applications are discussed in this review.

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“…The EC layer of the testing buccal tablet was glued at the bottom of a glass vial connected with the balance. The tablet (mucoadhesive core layer) was allowed to contact with porcine buccal membrane for 5 min with a load weight of 5 g. Next, the load weight was removed and the weight (g) required to detach the adhered tablet from the mucous membrane was measured as described by Navamanisubramanian et al 28…”

Section: Ex Vivo Mucoadhesion Strengthmentioning

confidence: 99%

Pharmacokinetic Investigation to Study the In Vivo Bioavailability of Thiolated Chitosan Based Repaglinide Buccal Tablets

Navamanisubramanian¹,

Nerella²,

Shanmuganathan

2020

Pharm Sci

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Background: Repaglinide (REP) is an antihyperglycemic drug having low bioavailability due to its extensive first-pass metabolism. The present study aimed to develop and pharmacokinetic investigte the thiolated chitosan (TC) based buccal tablets of REP for improved bioavailability. Methods: TC was prepared by conjugation of L-cysteine with chitosan. The amount of free thiol groups present in TC was determined by UV-spectrophotometry using Ellman’s reagent. TC based REP buccal tablets were prepared by two layers co-compression method and characterized for in vitro and ex vivo parameters. The in vivo performance of prepared REP buccal tablets was assessed by the pharmacokinetic study in New Zealand white rabbits. Results: The prepared TC resulted in 87%w/w yield with 52.3±3.2 μM free thiol functional groups per 10 mg of TC. The prepared formulations have good flow nature and compressibility, acceptable thickness (2.02 to 2.1 mm), weight (60.11 to 61.06 mg), surface pH (6.59 to 6.81) and drug content (98.92 to 101.08 %w/w). The presence of TC significantly improved the mucoadhesion strength, sustained the in vitro release and enhanced the ex vivo permeation of REP buccal tablets. The shelf life of REP buccal tablets was found to be 15.07 months in accelerated storage conditions. The prepared REP buccal tablets (V5) have area under the curve (712.22±15.91 ng/mL/h) and mean residence time (4.66±0.25 h) was 1.89 and 1.83 folds higher than oral bolus respectively. Conclusion: TC based REP buccal tablets are capable of controlled transbuccal release of REP for a prolonged time and have better bioavailability than oral bolus.

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Use of Okra Mucilage and Chitosan Acetate in Verapamil Hydrochloride buccal patches development; In vitro and Ex vivo Characterization

Cited by 8 publications

References 11 publications

Formulation and Evaluation of Fast Dissolving Sublingual Film of Paroxetine Hydrochloride for Treatment of Depression

Formulation and Evaluation of Fast Dissolving Sublingual Film of Paroxetine Hydrochloride for Treatment of Depression

Okra (Abelmoschus esculentus L.) as a Potential Functional Food Source of Mucilage and Bioactive Compounds with Technological Applications and Health Benefits

Pharmacokinetic Investigation to Study the In Vivo Bioavailability of Thiolated Chitosan Based Repaglinide Buccal Tablets

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