Use of onsite typhoid IgG/IgM combo test as rapid diagnostic test for typhoid fever

Mohamed, Alaa Aboud; Ebeid, Basel; Abdel-Latif, Radwa Ahmed Rabea; Malak, Marian

doi:10.1186/s43088-023-00391-8

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…On the other hand, more than 50% of resistant cases were found in treatment by nalidixic acid (76%), ampicillin (98%) and amoxicillin (98%). These findings were similar to the findings of another study conducted by Mohamed et al ( 2023) [16]. Another study by Bulbul Hasan et al [10] found an antimicrobial susceptibility pattern of 16 isolates of S. typhi showing that no isolate was resistant to Ceftriaxone and Ceftazidime, only 03(18.75%) was resistant to Ciprofloxacin and Azithromycin whereas 10(62.5%) were MDR showing resistance to Ampicillin, Cotrimoxazole and Chloramphenicol which are first-line anti typhoidal drugs.…”

Section: Discussionsupporting

confidence: 93%

Antimicrobial Sensitivity Pattern Of Commonly Used Antibiotics Among Adult Enteric Fever Patients

Masum,

Sarker,

Ahmed

et al. 2024

JOPSOM

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Background: Enteric fever which is a very common bacterial infection in the Bangladeshi population is most commonly acquired by ingestion of water and food contaminated with feces or urine of carriers. Drug resistance in typhoid fever is considered one of the important factors in the morbidity and mortality of the disease. The emergence of strains of Salmonella Typhi resistant to multiple antibiotics poses a serious problem. The increasing frequency of antibiotic resistance has been reported from all parts of the world, but more so from developing countries. Thus this study aim to assess the antimicrobial sensitivity pattern of commonly used antibiotics among adult enteric fever patients. Methods: This cross-sectional comparative study was conducted in the Department of Medicine of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2015 to December 2015. In total 150 individuals were included in this study as the study subjects who were divided into two groups. In Group A, a total of 50 confirmed enteric fever cases and in Group B, a total of 100 non-enteric febrile adult patients were included. A non-probability purposive sampling technique was used in sample collection. All data were processed, analyzed and disseminated by using the MS Office program. For this analysis to fulfill the objective of this study, mainly data from 50 confirmed enteric fever cases were considered. Results: In this study, among the total of our 50 enteric fever cases with isolated salmonellae organisms including S. typhi and S. Paratyphi, during the treatment procedure, as the antibiotics cefepime, cefixime, ceftazidime, ciprofloxacin, imipenem, meropenem and ofloxacin showed 100% sensitivities. Besides ceftriaxone, cotrimoxazole, chloramphenicol and azithromycin showed 98%, 68%, 66% and 54% sensitivities respectively (>50%). On the other hand, more than 50% of resistant cases were found in treatment by nalidixic acid (76%), ampicillin (98%) and amoxicillin (98%). Conclusion: Till today, considering the lower treatment cost and better patient compliance ciprofloxacin may be considered as the drug of choice in treating adult enteric fever patients. Besides cefepime, cefixime, ceftazidime, ciprofloxacin, imipenem, meropenem or ofloxacin can be used in such cases confidently. JOPSOM 2021; 41(2):43-49

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Section: Discussionsupporting

confidence: 93%

Antimicrobial Sensitivity Pattern Of Commonly Used Antibiotics Among Adult Enteric Fever Patients

Masum,

Sarker,

Ahmed

et al. 2024

JOPSOM

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“…The Typhoid IgG/IgM combo test (lateral flow immunoassay) results were positive in approximately 24% of all patients and demonstrated 72.4% sensitivity, 98.4% specificity, 95.5% positive predictive value and 88.2% negative predictive value. 5 Our patient started with a fever but without respiratory symptoms. As a patient with a pacemaker implant, he was thoroughly investigated for an infection.…”

Section: Discussionmentioning

confidence: 67%

Infections associated with haemophagocytic syndrome: A case report of a rare coexistence with common infections

Anamika,

Momin,

Kaladhar

et al. 2024

Sri Lankan J Infec Dis

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Infection-associated haemophagocytic syndrome (IAHS) is exceptional in typhoid and tuberculosis co-infections. We encountered a 50-year-old man with a history of pacemaker implantation who was previously treated for typhoid fever and currently presented with a chronic fever and shortness of breath. Initial laboratory tests revealed pancytopenia. A bone marrow aspiration was performed. However, due to cardiac problems, a bone marrow biopsy could not be performed. A bone marrow aspirate was submitted for cell block preparation. The cytology of the bone marrow aspirate revealed hemophagocytosis, which was initially presumed to be secondary to typhoid. Subsequently, cell block preparation of the bone marrow aspirate exhibited numerous granulomas with necrosis suggestive of tuberculosis. The patient was successfully treated with anti-tuberculosis drugs, steroids, and antibiotics. This case highlighted an association between IAHS and a common tropical illness. The usefulness of an aspirate cell block in the absence of biopsy and the potential existence of tuberculosis, especially in tuberculosis-endemic countries is to be noted.

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Use of onsite typhoid IgG/IgM combo test as rapid diagnostic test for typhoid fever

Cited by 2 publications

References 14 publications

Antimicrobial Sensitivity Pattern Of Commonly Used Antibiotics Among Adult Enteric Fever Patients

Antimicrobial Sensitivity Pattern Of Commonly Used Antibiotics Among Adult Enteric Fever Patients

Infections associated with haemophagocytic syndrome: A case report of a rare coexistence with common infections

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