Use of oral fluralaner for the treatment of <i>Psoroptes cuniculi</i> in 15 naturally infested rabbits

Sheinberg, Galia; Núñez, Camilo Romero; Heredia, Rafael; Capulin, Miguel; Yarto, Enrique; Carpio, Juan G. Cornejo del

doi:10.1111/vde.12429

Cited by 22 publications

(17 citation statements)

References 7 publications

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“…Anecdotal evidence suggests that these products have a high efficacy rate at the doses labelled for flea and tick prevention against parasites including Demodex species, Sarcoptes species, Otodectes species, Cheyletiella species, Lynxacarus species and various poultry mites 2 12–15. Use in off‐label hosts including poultry, pigs, rabbits, hedgehogs and wildlife suggest this drug class has a wide margin of safety 16–24. Consideration for use in human beings using porcine models of disease may lead to promising breakthroughs in control of parasitic infections in endemic regions of the world 25.…”

Section: Discussionmentioning

confidence: 99%

Use of oral fluralaner (Bravecto) to successfully manage adult‐onset generalised demodicosis in a silver fox (Vulpes vulpes)

Burke

Kottwitz

Wang

et al. 2019

Vet Record Case Reports

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A six-year-old spayed female silver fox (Vulpes vulpes) presented with bilateral ocular discharge, lethargy, facial alopecia and dermatitis of six months’ duration. The fox was immobilised with ketamine (4 mg/kg), dexmedetomidine (0.01 mg/kg) and butorphanol (0.05 mg/kg) intramuscularly for skin cytology, skin scrapings, dermatophyte culture, bloodwork, faecal floatation and skin biopsies. Diagnostics revealed numerous Demodex species mites. Histopathology showed folliculitis, perifolliculitis and furunculosis with mites, identified as Demodex canis using RT-PCR. The fox received meloxicam (0.2 mg/kg by mouth, three days), cefovecin (8.6 mg/kg subcutaneously, single injection), praziquantel (56.8 mg, subcutaneously, single injection), and fluralaner (250 mg, by mouth, once every 12 weeks, Bravecto). Complete resolution was noted one month after initiating treatment. Thirteen months later the fox remains mite-free and is receiving fluralaner by mouth every 12 weeks. This case report describes successful management of adult-onset generalised Demodex species dermatitis in a silver fox using oral fluralaner.

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Section: Discussionmentioning

confidence: 99%

Use of oral fluralaner (Bravecto) to successfully manage adult‐onset generalised demodicosis in a silver fox (Vulpes vulpes)

Burke

Kottwitz

Wang

et al. 2019

Vet Record Case Reports

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“…Selamectin is a macrocyclic lactone which has been proven to be effective in acariasis in multiple species and is regularly used in exotic animals [11]. Isoxazolines, such as sarolaner, also have proven highly effective acaricidal activity against mites of the orders Psoroptidae and Sarcoptidae, such as Otodectes or Sarcoptes, respectively, and to date, no species-specific intolerance has been described [12][13] [14]. Spot-on formulations containing systemically active selamectin and/or different isoxazolines offer an attractive route of application, due to their ease of administration and a duration of action spanning multiple weeks, especially in species where regular handling is difficult [15] [16].…”

Section: Introductionmentioning

confidence: 99%

Morphological diagnosis and successful treatment of chorioptic mange in 2 South American coatis (Nasua nasua)

Klinger¹,

Boehm

Roller³

et al. 2021

Tierarztl Prax Ausg G Grosstiere Nutztiere

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Two female South American coatis (Nasua nasua) kept in a zoo in Southern Germany presented with pruritus and moderate hair loss at the dorsal trunk, thigh areas and alongside the tail. Otherwise the animals showed no clinical signs. While the clinical general examination as well as cytology of dermatologic samples showed no pathologic changes, Chorioptes sp. mites could be identified in a superficial skin scraping. Two consecutive topical applications of a selamectin/sarolaner spot-on formulation 4 weeks apart lead to a complete resolution. No side effects were observed.

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“…Due to the fact that the mite life cycle is 21 days, the treatments are long and can extend up to a period of 3 to 4 weeks, and require the administration of at least two doses [9]. As an alternative, the use of oral fluralaner, 25 mg / kg dose, is reported as an effective treatment in a single application [10]. (Nexgard Spectra1) is a tablet that contains both afoxalaner and milbemycin oxime constituents, and it is indicated in dogs as a treatment of ectoparasites, but there are no reports on its use in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of afoxalaner with milbemycin 1 oxime in the treatment of rabbits naturally infected with Psoroptes cuniculi

Núñez

Ortega

Waisburd³

et al. 2020

PLoS ONE

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Rabbits (Oryctolagus cuniculi) are very popular as pets. However, problems of otitits caused by Psoroptes cuniculi are one of the main reasons to visit the veterinarian. Isoxazolines are an alternative treatment to treat this mite, and therefore, an evaluation of the effectiveness of oral afoxalaner with milbemycin oxime in rabbits infected with P. cuniculi was carried out. Nineteen rabbits, of New Zealand breed, with otitis due to an infection with P. cuniculi, were treated, whereas six rabbits were left untreated and formed the control group. The ear canals of each individual were examined, through the collection of otic exudate samples with cotton swabs. These were visualized under the microscope to identify the ectoparasite. Each animal was treated with a single oral dose of 2.50 mg / kg of afoxolaner, and 0.50 mg / kg of milbemycin oxime. Clinical signs and lesions associated with the infection, such as the presence of detritus, cerumen and / or scabs, and erythema, were evaluated. After receiving the treatment, all the lesions were classified as: mild, moderate and intense, with a visual analog scale. A week after providing medication, there was a decrease in the lesions of the group treated with Nexgard Spectra®, without further topical or systemic treatment. The decrease was gradual in the treated group and no recurrence was detected of P. cuniculi infection in both ears. Thus, the administration of a single oral dose of afoxolaner with milbemycin oxime was effective for the treatment of P. cuniculi infection in rabbits.

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Use of oral fluralaner for the treatment of Psoroptes cuniculi in 15 naturally infested rabbits

Abstract: Administration of a single oral dose of fluralaner was effective for the treatment of naturally occurring P. cuniculi infestation in rabbits during a 90 day period.

Cited by 22 publications

References 7 publications

Use of oral fluralaner (Bravecto) to successfully manage adult‐onset generalised demodicosis in a silver fox (Vulpes vulpes)

Use of oral fluralaner (Bravecto) to successfully manage adult‐onset generalised demodicosis in a silver fox (Vulpes vulpes)

Morphological diagnosis and successful treatment of chorioptic mange in 2 South American coatis (Nasua nasua)

Evaluation of the effect of afoxalaner with milbemycin 1 oxime in the treatment of rabbits naturally infected with Psoroptes cuniculi

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