Use of oral midazolam in pediatric upper gastrointestinal endoscopy

Rafeey, Mandana; Ghojazadeh, Morteza; Zadeh, Hosain Feizo Allah; Majidi, Hamideh

doi:10.1111/j.1442-200x.2009.02936.x

Cited by 13 publications

(14 citation statements)

References 27 publications

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“…The most common agent evaluated was PO midazolam. [7][8][9][10][11][12][13][14][19][20]22 Table 4 provides a summary of dosing information and adverse events reported in the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Rafeey and colleagues 22 compared PO midazolam, 0.5 mg/kg, to IV midazolam, 0.05 to 0.1 mg/kg, in 61 children undergoing esophagogastroduodenoscopy. The IV midazolam solution was used to make a 2.5 mg/mL oral solution, which was administered 30 minutes prior to the procedure.…”

Section: Upper Gastrointestinal Endoscopymentioning

confidence: 99%

“…Two studies evaluated procedural sedation in pediatric upper GI procedures. [21][22] Michaud and colleagues 21 studied the safety and efficacy of 50% N 2 O for sedation during endoscopy. N 2 O was administered for 3 to 8 minutes prior to endoscopy in all patients and was continuously given during the procedure in 62% of patients.…”

Section: Upper Gastrointestinal Endoscopymentioning

confidence: 99%

“…Seven studies included a comparator group; all with a relatively small sample size, making it difficult to draw conclusions. 4,7,[13][14][19][20]22 Three studies compared PO or IN midazolam to PO chloral hydrate. 4,13,19 It should be noted that chloral hydrate is no longer commercially available, although some institutions may compound a solution.…”

Section: Practical Considerationsmentioning

confidence: 99%

“…Eight studies provided details for preparation of PO midazolam; all 8 studies used the IV midazolam solution in a sweetened drink. [7][8][9][10][11][12][13][14][19][20]22 Oral midazolam syrup is now commercially available, which is considered more tolerable. TM dexmedetomidine with the IV formulation was said to be well tolerated because of bland taste and minimal volume required, and no children refused it in the study by Lami et al 6 IN midazolam was administered using the IV product delivered by dropper or MAD.…”

Section: Practical Considerationsmentioning

confidence: 99%

See 4 more Smart Citations

Non-Intravenous Sedatives and Analgesics for Procedural Sedation for Imaging Procedures in Pediatric Patients

Thomas

Miller

Couloures

et al. 2015

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVES:The purpose of this study was to describe the method of delivery, dosage regimens, and outcomes of sedatives administered by extravascular route for imaging procedures in children. METHODS: Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Database of Systematic Reviews were searched using keywords "child", "midazolam", "ketamine", dexmedetomidine", "fentanyl", "nitrous oxide", and "imaging. " Articles evaluating the use of extravascular sedation in children for imaging procedures published in English between 1946 and March 2015 were included. Two authors independently screened each article for inclusion. Reports were excluded if they did not contain sufficient details on dosage regimens and outcomes. RESULTS: Twenty reports representing 1,412 patients ranging in age from 0.33 to 19 years of age were included for analysis. Due to discrepancies in doses and types of analyses, statistical analyses were not performed.

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Section: Resultsmentioning

confidence: 99%

Section: Upper Gastrointestinal Endoscopymentioning

confidence: 99%

Section: Upper Gastrointestinal Endoscopymentioning

confidence: 99%

Section: Practical Considerationsmentioning

confidence: 99%

Section: Practical Considerationsmentioning

confidence: 99%

See 3 more Smart Citations

Non-Intravenous Sedatives and Analgesics for Procedural Sedation for Imaging Procedures in Pediatric Patients

Thomas

Miller

Couloures

et al. 2015

The Journal of Pediatric Pharmacology and Therapeutics

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Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

et al. 2015

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Midazolam oral solution (Ozalin®): a profile of its use for procedural sedation or premedication before anaesthesia in children

Lyseng‐Williamson

2019

Drugs Ther Perspect

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Ozalin ® , a novel oral solution of 0.2% midazolam, is an effective option for moderate sedation prior to a therapeutic or diagnostic procedure, and as premedication before anaesthesia, in infants, children and adolescents. Orally administered midazolam has a rapid onset and short duration of action, with well-established favourable efficacy, tolerability, safety and acceptability profiles in these indications. To overcome the problems of bitter taste and inconsistent bioavailability associated with extemporaneous formulations of oral midazolam, Ozalin, a commercially prepared oral midazolam formulation, contains the inert excipient γ-cyclodextrin, which forms inclusion complexes with midazolam, thereby enhancing the solubility and stability of midazolam solutions, and masking its bitter taste. Ozalin is administered at the lowest dose of midazolam (i.e. 0.25 mg/kg) that has been shown to be effective, with this dose providing sedative effects consistent with the historical data for midazolam at doses that were the same or higher (i.e. 0.5-1.5 mg/kg). Adis evaluation of Ozalin ® for procedural sedation or premedication before anaesthesia in paediatric patients (aged 6 months to 17 years)

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Use of oral midazolam in pediatric upper gastrointestinal endoscopy

Abstract: Oral administration of midazolam is a safe and effective method of sedation that significantly reduces anxiety and improves overall tolerance for children undergoing esophagogastroduodenoscopy.

Cited by 13 publications

References 27 publications

Non-Intravenous Sedatives and Analgesics for Procedural Sedation for Imaging Procedures in Pediatric Patients

Non-Intravenous Sedatives and Analgesics for Procedural Sedation for Imaging Procedures in Pediatric Patients

Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

Midazolam oral solution (Ozalin®): a profile of its use for procedural sedation or premedication before anaesthesia in children

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