Use of osteocalcin-specific Gpr158 protein in biosensor technology for osteocalcin detection

Ertuğrul Uygun, Hilmiye Deniz

doi:10.1007/s11696-024-03500-8

Chem. Pap.

2024

DOI: 10.1007/s11696-024-03500-8

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Use of osteocalcin-specific Gpr158 protein in biosensor technology for osteocalcin detection

Hilmiye Deniz Ertuğrul Uygun

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2024

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A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

Liu,

Lai,

Gao

et al. 2024

Preprint

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Rapid escape against visual threats is critical for survival. Whether it requires a permissive mechanism is unknown. Here, we show that osteocalcin (OCN), a protein produced by bone and persisted in the brain, primes rapid visual escape response by increasing excitability of VTA GABAergic neuron subpopulation via OCN-GPR37-cAMP-THIK-1 (K2P13.1) pathway. Knock-out of OCN or its receptor GPR37, and conditional knock-out of GPR37 in VTA GABAergic or glutamatergic neurons caused delayed escape. Reconstituting OCN-GPR37 signaling specifically in VTA was sufficient to restore normal response. Single-cell transcriptomics combined with electrophysiology showed that OCN decreases potassium currents in a subpopulation of VTA GABAergic neurons via GPR37-induced cAMP reduction and subsequent THIK-1 suppression. This elevation of excitability in VTA neuron subpopulation can be recapitulated by HM4Di, an inhibitory chemogenetic GPCR commonly used to suppress neuronal activity. Our study demonstrated that visual behavior requires a bone-derived protein that tunes electrophysiology of central nervous system neurons.

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A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

Liu,

Lai,

Gao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Use of osteocalcin-specific Gpr158 protein in biosensor technology for osteocalcin detection

Cited by 1 publication

References 18 publications

A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

A bone-derived protein primes rapid visual escape via GPR37 receptor in a subpopulation of VTA GABAergic neurons

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