Use of pamidronate for osteoporosis treatment in public health care in Brazil

Zanatta, Leila Bianchet; Marcatto, Cristina; Ramos, Cássio Slompo; Mañas, Nádila Cecyn Pietszkowski; Moreira, Carolina Aguiar; Borba, Victoria

doi:10.1016/j.rbre.2016.07.005

Cited by 2 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While a monthly dosage is useful and higher BMD is the goal for countermeasures in flight, a higher incidence of adverse effects should indicate a risk analysis for viability of IBN as an acceptable option. For Pamidronate (PMD), a records analysis of 70 women in Brazil who were treated with PMD for osteoporosis showed a significant gain in BMD in the spinal column, but there was no concurrent gain in BMD of the femur [41]. It was also noted that there was elevated PTH levels in some of the patients which was correlated with lower femoral BMD [41].…”

Section: Pharmacologicmentioning

confidence: 99%

“…For Pamidronate (PMD), a records analysis of 70 women in Brazil who were treated with PMD for osteoporosis showed a significant gain in BMD in the spinal column, but there was no concurrent gain in BMD of the femur [41]. It was also noted that there was elevated PTH levels in some of the patients which was correlated with lower femoral BMD [41]. Another study showed that in a retrospective cohort of 74 postmenopausal women, a placebo group showed elevated spine, hip, and femur BMD compared to a group treated with PMD [42].…”

Section: Pharmacologicmentioning

confidence: 99%

“…The common intuitive step to prevent skeletal muscle breakdown is increased amino acid intake. Leucine derivatives may be protective for bone health [40,41]. Unfortunately, studies show increased protein intake is also linked to hypercalciuria [55,56].…”

Section: Dietarymentioning

confidence: 99%

See 2 more Smart Citations

Risks and Countermeasures for the Musculoskeletal systems in the Extreme Environment of Aviators and Astronauts

2021

J Phys Med Rehabil

View full text Add to dashboard Cite

Risks and Effects Flying in JetsMilitary aviation, especially when conducted in high performance jet aircraft (HPJA), produces defined unique stressors on structural elements of the human body. In addition, because many astronaut pilots and commanders are prior military HPJA aircrew, it becomes even more important to consider the physiologic implications of jet flight. Pilots are exposed to a large amount of both physical and mental stress during training and duty, and because of this selection pressure, pilots are typically young and fit compared to the general population [2]. New generations of fighter aircraft have pushed both planes and aviators to the limits of their capabilities, such that even young and fit pilots are prone to injuries that occur as a result of flight.The high G-force maneuvers and rapid forces that act upon pilots are detrimental to the spinal cord and neck. The large magnitude of forces that a pilot experiences compounded with the small cockpit dimensions and

show abstract

Section: Pharmacologicmentioning

confidence: 99%

Section: Pharmacologicmentioning

confidence: 99%

See 1 more Smart Citation

Risks and Countermeasures for the Musculoskeletal systems in the Extreme Environment of Aviators and Astronauts

2021

J Phys Med Rehabil

View full text Add to dashboard Cite

show abstract

Effect of medications on prevention of secondary osteoporotic vertebral compression fracture, non-vertebral fracture, and discontinuation due to adverse events: a meta-analysis of randomized controlled trials

Jin

Lee

et al. 2019

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Bone loss with aging and menopause increases the risk of fragile vertebral fracture, osteoporotic vertebral compression fracture (OVCF). The fracture causes severe pain, impedes respiratory function, lower the quality of life, and increases the risk of new fractures and deaths. Various medications have been prescribed to prevent a secondary fracture, but few study summarized their effects. Therefore, we investigated their effects on preventing subsequent OVCF via meta-analyses of randomized controlled trials. Methods: Electronic databases, including MEDLINE, EMBASE, CENTRAL, and Web of Science were searched for published randomized controlled trials from June 2015 to June 2019. The trials that recruited participants with at least one OVCF were included. We assessed the risk of bias of every study, estimated relative risk ratio of secondary OVCF, non-vertebral fracture, gastrointestinal complaints and discontinuation due to adverse events. Finally, we evaluated the quality of evidence. Results: Forty-one articles were included. Moderate to high quality evidence proved the effectiveness of zoledronate (Relative Risk, RR: 0.34; 95% CI, 0.17-0.69, p = 0.003), alendronate (RR: 0.54; 95% CI: 0.43-0.68; p < 0.0001), risedronate (RR: 0.61; 95% CI: 0.51-0.73; p < 0.0001), etidronate (RR, 0.50; 95% CI, 0.29-0.87, p < 0.01), ibandronate (RR: 0.52; 95% CI: 0.38-0.71; p < 0.0001), parathyroid hormone (RR: 0.31; 95% CI: 0.23-0.41; p < 0.0001), denosumab (RR, 0.41; 95% CI, 0.29-0.57; p < 0.0001) and selective estrogen receptor modulators (Raloxifene, RR: 0.58; 95% CI: 0.44-0.76; p < 0.0001; Bazedoxifene, RR: 0.66; 95% CI: 0.53-0.82; p = 0.0002) in preventing secondary fractures. Moderate quality evidence proved romosozumab had better effect than alendronate (Romosozumab vs. alendronate, RR: 0.64; 95% CI: 0.49-0.84; p = 0.001) and high quality evidence proved that teriparatide had better effect than risedronate (risedronate vs. teriparatide, RR: 1.98; 95% CI: 1.44-2.70; p < 0.0001).

show abstract

Use of pamidronate for osteoporosis treatment in public health care in Brazil

Abstract: The intravenous pamidronate in a group of postmenopausal women with predominant high risk of fracture promoted an isolated gain in the spine BMD, even though, clinical randomized trials are needed to confirm its anti-fracture efficacy.

Cited by 2 publications

References 25 publications

Risks and Countermeasures for the Musculoskeletal systems in the Extreme Environment of Aviators and Astronauts

Risks and Countermeasures for the Musculoskeletal systems in the Extreme Environment of Aviators and Astronauts

Effect of medications on prevention of secondary osteoporotic vertebral compression fracture, non-vertebral fracture, and discontinuation due to adverse events: a meta-analysis of randomized controlled trials

Contact Info

Product

Resources

About