<span>Reservoirs are often built in cascade on the same river system, introducing inexorable constraints. It is therefore strategically important to scheme out an efficient commitment of thermal generation units along with the scheduling of hydro generation units for better operational efficiency, considering practical system conditions. This paper develops a comprehensive, unit-wise hydraulic model with reservoir and river system constraints, as well as gas constraints, with head effects, to commit thermal generation units and schedule hydro ones in the short-term. A mixed integer linear programming (MILP) methodology, using the branch and bound & cut (BB&C) algorithm, is employed to solve the resultant problem. Due to the detailed modelling of individual hydro units and cascaded dependent reservoirs, the problem size is substantially swollen. Multithread computing is invoked to accelerate the solution process. Simulation results, conducted on various test systems, reiterate that the developed MILP-based hydrothermal scheduling approach outperforms other techniques in terms of cost efficiency.</span>