Use of Partition Models in Setting Health Guidelines for Volatile Organic Compounds

Hau, K.M.; Connell, Des; Richardson, Bruce J.

doi:10.1006/rtph.1999.1357

Cited by 14 publications

(14 citation statements)

References 32 publications

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“…Such correlations are of limited practical use, and of no mechanistic value. A more detailed analysis [33,34] led to equation (6), where the ODT values were taken from the AlHA compilation [35].…”

Section: Resultsmentioning

confidence: 99%

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The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

Abraham

Gola

Cometto‐Muñiz

et al. 2001

Indoor and Built Environment

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A general equation set up for the study of transport properties has been applied to VOC nasal pungency and eye irritation thresholds, as log (1/NPT) and log (1/EIT).The equation accounts for 93-95 % of the total effect, thus suggesting that the main step is transport of the VOC from the gas phase to a receptor phase. In the case of odor thresholds, ODT, the general equation accounts for only 77% of the total effect.A modified equation incorporates a factor for aliphatic aldehydes and carboxylic acids, and a general size effect that depends on the VOC maximum length. The size effect is important in that it leads to a cut-off effect that greatly reduces the potency of higher homologues. The various equations can all be used to predict chemosensory thresholds for thousands of VOCs.

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Section: Resultsmentioning

confidence: 99%

“…This predicted cut-off effect has a very important consequence. Hau et al [34] have used their partition model [33] to predict odor thresholds for VOCs found in the indoor environment. This partition model does not include any cut-off effect at all, and hence higher homologues will be predicted to be much more potent than on our model.…”

Section: Resultsmentioning

confidence: 99%

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

Abraham

Gola

Cometto‐Muñiz

et al. 2001

Indoor and Built Environment

View full text Add to dashboard Cite

show abstract

“…For a number of homologous series, b ranged between 0.91 and 1.88 [34]. Hence the mechanistic significance of equation (6) is that the main process is transfer of the VOC from the gas phase to a medium that resembles wet octanol.…”

Section: Odour Thresholdsmentioning

confidence: 99%

“…This predicted cut-off effect has a very important consequence. Hau et al [34] have used their partition model [33] to predict ODTs for VOCs found in the indoor environment. This partition model does not include any cut-off effect at all, and hence higher homologues will be predicted to be much more potent than on our model.…”

Section: Odour Thresholdsmentioning

confidence: 99%

See 1 more Smart Citation

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

Abraham¹,

Gola²,

Cometto-Muñiz³

et al. 2001

Indoor Built Environ

View full text Add to dashboard Cite

A general equation set up for the study of transport properties has been applied to volatile organic compound (VOC) nasal pungency and eye irritation thresholds, as log (1/NPT) and log (1/EIT). The equation accounts for 93–95% of the total effect, thus suggesting that the main step is transport of the VOC from the gas phase to a receptor phase. In the case of odour thresholds the general equation accounts for only 77% of the total effect. A modified equation incorporates a factor for aliphatic aldehydes and carboxylic acids, and a general size effect that depends on the VOC maximum length. The size effect is important in that it leads to a cut-off effect that greatly reduces the potency of higher homologues. The various equations can all be used to predict chemosensory thresholds for thousands of VOCs.

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A Study of the Biological Partitioning Behavior of n-Alkanes and n-Alkanols in Causing Anesthetic Effects

Hau

Connell

Richardson

2002

Regulatory Toxicology and Pharmacology

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Use of Partition Models in Setting Health Guidelines for Volatile Organic Compounds

Cited by 14 publications

References 32 publications

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

The Correlation and Prediction of VOC Thresholds for Nasal Pungency, Eye Irritation and Odour in Humans

A Study of the Biological Partitioning Behavior of n-Alkanes and n-Alkanols in Causing Anesthetic Effects

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