Use of Perfluorocarbon based Blood Substitute Perftoran in Correction of Hypoxia During Acute Anemia in Animals

Abstract

The cause of acute and severe hypoxia of the organism is acute posthemorrhagic anemia. To eliminate posthemorrhagic anemia in animals, the perfluorocarbon blood substitute Perftoran (Russia) with a gas-transporting function was used. The aim of this study was to determine the clinical effectiveness of the perfluorocarbon based blood substitute Perftoran with a gas-carrying function in acute posthemorrhagic anemia in animals and reveal possible side effect of the blood substitute and remove them. In the study conducted in the Clinic of Veterinary Medicine of Pushchino Research Center (Russia) participated 20 cats of both sexes, who were admitted with internal bleeding as a result of injuries. The animals were divided into two groups: the control and the treatment groups (10 per group). All animals with anemia were examined according to the standard scheme: anamnesis vitae and anamnesis morbi, physical examination (basic methods of research were used), additional methods that were used: complete blood count (CBC) and biochemical analysis of blood (BA), microscopy of blood smears, abdominal ultrasonography. Based on the obtained results, we can conclude that the use of the gas-carrying substitute for donor blood Perftoran in the treatment group of animals with posthemorrhagic anemia, which resulted from polytrauma, eliminated tissue hypoxia; the treatment of the animals in the control group with standard solutions (by infusing Stabisol) without gas transport correction led to the development of persistent hypoxia, which persisted to the stage of reticulocyte crisis.

Therapeutic oxygen delivery by perfluorocarbon-based colloids

“…Resuscitation of mice from hemorrhagic shock using F-octylbromide emulsified with RBC membrane proteins was deemed comparable to that obtained with whole blood [51,54]. Reduction of tissue hypoxia with Perftoran in cats with post-hemorrhagic anemia was reported [309]. Blood from sickle cell disease patients, when mixed with a PFC emulsion in vitro, showed increased O 2 extraction, indicating facilitated O 2 transport [310].…”