Use of PET/CT instead of CT-only when planning for radiation therapy does not notably increase life years lost in children being treated for cancer

Kornerup, J. Ståhl; Brodin, P.; Christensen, Christa Lykke; Björk‐Eriksson, Thomas; Kiil-Berthelsen, A.; Borgwardt, Lise; Rosenschöld, Per Munck af

doi:10.1007/s00247-014-3197-4

Cited by 4 publications

(6 citation statements)

References 38 publications

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“…64 For the 11 patients in the study at hand, effective PET/CT doses were on average 30 mSv and the 18 F-FDG PET contributed with approximately 25-30% of that. Regardless, unnecessary radiation dose should always be avoided, and it is therefore important to thoroughly assess the value as well as the risks of including 18 F-FDG PET in radiotherapy planning.…”

Section: Plan Quality and Risk Estimationsmentioning

confidence: 93%

PET/CT-guided treatment planning for paediatric cancer patients: a simulation study of proton and conventional photon therapy

Kornerup

Brodin

Björk‐Eriksson

et al. 2015

BJR

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Section: Plan Quality and Risk Estimationsmentioning

confidence: 93%

PET/CT-guided treatment planning for paediatric cancer patients: a simulation study of proton and conventional photon therapy

Kornerup

Brodin

Björk‐Eriksson

et al. 2015

BJR

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“…A study on oncology patients conducted by Khamwan et al (2010) reported an average PET dose of 4.4 mSv and a CT dose of 14.5 mSv (contributing 77% of the total effective dose) [11]. A recent study on pediatric patients by Kornerup et al (2015) found that an average of CT effective dose of 35.0 mSv, accounting for 75% of the total effective dose from PET/CT scans that have high-resolution diagnostic quality [2].…”

Section: Dosimetry Of Pet/ctmentioning

confidence: 99%

“…The relationship between ionizing radiation exposure and radiation-induced disease is becoming increasingly noteworthy. The health risks of ionizing radiation exposure from medical imaging studies have become an important issue, drawing attention from both medical professionals and the public during the past 30 years [2] [12] [13].…”

Section: Radiation-induced Health Riskmentioning

confidence: 99%

“…The CTAC dose can be reduced from a range of 3.2 -8.3 mSv to 0.9 -3.2 mSv. This is especially beneficial for radiation-sensitive patients such as children, young adults and pregnant women [2] [27] [28] [29]. Another study conducted evaluated a new CT dose reduction method for PET/CT imaging, applying the "selective CT" technique for localization in follow-up studies of pediatric patients with Langerhans cell histiocytosis.…”

Section: Ct-based Attenuation Correction (Ac) Strategymentioning

confidence: 99%

“…Over the past 30 years, PET imaging has improved from a research tool to a strong imaging tool. The continues development of hardware, software, imaging techniques and radiopharmaceuticals, lead to expanded the PET role in many areas, including, but not limited to cardiology, neurology, endocrinology, image-guided therapy planning, biopsy, delineation of pathologic volume, treatment management and pharmacology research [1] [2].…”

Section: Introductionmentioning

confidence: 99%

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Strategies to Improve CT Dose Optimization for Hybrid PET/CT Imaging

Yaseen¹,

Radzi²,

Almohiy³

et al. 2021

OJMI

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Background: To evaluate whether current dose reduction strategies for the CT component of hybrid Positron Emission Tomography-Computed Tomography (PET/CT) systems could reduce patient dose with maintaining adequate image quality for PET/CT studies. Materials and Methods: Literature survey was initially based on the selection of keywords and years of publication to identify potentially relevant articles, then the further search was conducted on the authors and references from these articles. The abstract of each article was first appraised to decide whether the content was relevant to this research question. The articles were classified into five groups: studies on dosimetry, studies on radiation-induced diseases, studies on dose reduction methods for CT-based attenuation correction (CTAC), studies on dose reduction methods for CT localization, and studies on reducing the need for a full-dose diagnostic CT in PET/CT imaging. 58 peer-reviewed articles were selected and appraised and 29 articles were used to compose this literature review. Results: The published nuclear medicine and medical physics literature were reviewed. CT dose contributed 47% -81% of the total effective dose of a standard PET/CT study and was associated with radiation-induced diseases. The dose reduction techniques were extracted and divided into three categories: reducing the CT dose for attenuation correction (AC) and localization, selectively localizing CT use, and reducing the need for a full-dose diagnostic CT. Conclusion: Three strategies have been demonstrated, with high potential for reducing patient dose while maintaining an adequate CT image quality, used for CTCA localization and diagnosis, respectively.

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Optimized low-dose positron emission tomography/computed tomography schemes in pediatric tumor patients: a randomized clinical trial

Yu¹,

Qian²,

Liu³

et al. 2022

Transl Pediatr

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Background: It's clinically relevant to reduce the radiation dose to children while ensuring their positron emission tomography/computed tomography (PET/CT) image quality. The optimal protocol for wholebody PET/CT imaging in children (non-model) has been less studied. In this study, we investigated the optimal protocol for PET/CT imaging of pediatric oncology by analyzing the radiation dose and image quality in18F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) PET/CT imaging of children with oncology.Methods: One hundred children with tumors who underwent 18 F-FDG PET/CT were included. CT grouping: randomly divided into 18 groups A-R according to the combination of three parameters: tube voltage (80/120 kV), automatic milliamp range (20-39/40-59/60-80 mA), and noise index (NI) (8/12/14).PET grouping: randomly divided into 9 groups a-i according to the combination of two parameters: the pharmaceuticals injection dose (0.08/0.12/0.15 mCi/kg) and time per bed (120/150/180 s). The effective radiation dose (ED) was calculated separately for each group and the image quality of CT and PET was evaluated subjectively using standard deviation (SD) and coefficient of variation (CV) objective evaluation and 5-point evaluation method, respectively.Results: Ninety-seven images in CT and 57 images in PET were included. The best quality of CT images was in group K (120 kV/40-59 mA/8); there are 9 groups had good image quality and lower dose length product (DLP) than group K (SD ±10), while the difference in DLP between groups was large. The Kruskal-Wallis (K-W) test showed that the difference in image quality between the 9 groups was not statistically significant. The best PET image quality was in group i [0.15 (mCi/kg)/180 s]; there are four groups had good image quality and lower ED PET than group i (CV ±3.5%), while the difference in ED PET between groups was large (4.4-6.5 mSv), and the K-W test showed that the difference in image quality between the four groups was not statistically significant (P>0.05), with the lowest ED PET being in the g group. Conclusions:The optimal protocols for CT scanning and PET imaging in this experiment were group H (80 kV/40-59 mA/14) and group g [0.08 (mCi/kg)/180 s], respectively.

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Use of PET/CT instead of CT-only when planning for radiation therapy does not notably increase life years lost in children being treated for cancer

Abstract: Using FDG-PET/CT instead of CT only when defining the target volumes for radiation therapy of children with cancer does not notably increase the number of life years lost attributable to diagnostic examinations.

Cited by 4 publications

References 38 publications

PET/CT-guided treatment planning for paediatric cancer patients: a simulation study of proton and conventional photon therapy

PET/CT-guided treatment planning for paediatric cancer patients: a simulation study of proton and conventional photon therapy

Strategies to Improve CT Dose Optimization for Hybrid PET/CT Imaging

Optimized low-dose positron emission tomography/computed tomography schemes in pediatric tumor patients: a randomized clinical trial

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