Use of photoacoustic imaging to determine the effects of aging on lower extremity lymphatic vessel function

Suzuki, Yushi; Kajita, Hiroki; Oh, Anna; Takemaru, Masashi; Sakuma, Hisashi; Tsuji, Takao; Imanishi, Nobuaki; Aiso, Sadakazu; Kishi, Kazuo

doi:10.1016/j.jvsv.2021.05.001

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Studies showed that 3D highresolution imaging and differentiation of lymphatic and blood vessels is possible along with DBF characterization. [145][146][147][148][149][150] Figure 7 shows example PAI images.…”

Section: Lymphatic Vessel Detection Performancementioning

confidence: 99%

“…Light of the specific wavelength is absorbed by chromophores such as melanin, hemoglobin, or ICG, causing thermoelastic expansion and generating acoustic waves detected with an ultrasound transducer. Studies showed that 3D highresolution imaging and differentiation of lymphatic and blood vessels is possible along with DBF characterization [145][146][147][148][149][150]. Figure7shows example PAI images.Lymphedema severity classification was proposed based on visualization of lymphatic collectors, precollectors, and capillaries 148,150.…”

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confidence: 99%

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Imaging of the Lymphatic Vessels for Surgical Planning: A Systematic Review

et al. 2022

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Background Secondary lymphedema is a common complication after surgical or radiotherapeutic cancer treatment. (Micro) surgical intervention such as lymphovenous bypass and vascularized lymph node transfer is a possible solution in patients who are refractory to conventional treatment. Adequate imaging is needed to identify functional lymphatic vessels and nearby veins for surgical planning. Methods A systematic literature search of the Embase, MEDLINE ALL via Ovid, Web of Science Core Collection and Cochrane CENTRAL Register of Trials databases was conducted in February 2022. Studies reporting on lymphatic vessel detection in healthy subjects or secondary lymphedema of the limbs or head and neck were analyzed. Results Overall, 129 lymphatic vessel imaging studies were included, and six imaging modalities were identified. The aim of the studies was diagnosis, severity staging, and/or surgical planning. Conclusion Due to its utility in surgical planning, near-infrared fluorescence lymphangiography (NIRF-L) has gained prominence in recent years relative to lymphoscintigraphy, the current gold standard for diagnosis and severity staging. Magnetic resonance lymphography (MRL) gives three-dimensional detailed information on the location of both lymphatic vessels and veins and the extent of fat hypertrophy; however, MRL is less practical for routine presurgical implementation due to its limited availability and high cost. High frequency ultrasound imaging can provide high resolution imaging of lymphatic vessels but is highly operator-dependent and accurate identification of lymphatic vessels is difficult. Finally, photoacoustic imaging (PAI) is a novel technique for visualization of functional lymphatic vessels and veins. More evidence is needed to evaluate the utility of PAI in surgical planning.

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Section: Lymphatic Vessel Detection Performancementioning

confidence: 99%

mentioning

confidence: 99%

Imaging of the Lymphatic Vessels for Surgical Planning: A Systematic Review

et al. 2022

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“…56 The imaging system (PAL, photoacoustic lymphangiography) enabled the differentiation of lymphatic vessels from blood vessels by assigning different color codes. 57,58 (►Fig. 8).…”

Section: Clinical Imaging Of Lymphatic Vesselsmentioning

confidence: 99%

“… 59 Both PAI devices use ICG as a contrast medium for demonstrating lymphatic vessels and simultaneously obtaining 3D images of the vein. 57 58 60 The outstanding features of PAL allow direct observation of lymphaticovenous anastomosis anastomosis and postoperative patency. However, PAI can degrade image quality in areas with thick subcutaneous tissue commonly seen in patients with lymphedema due to light penetration.…”

Section: Lymphatic Systemmentioning

confidence: 99%

Evolution of Anatomical Studies on the Arterial, Venous, and Lymphatic System in Plastic Surgery

et al. 2022

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Anatomies of the vascular and lymphatic systems have been vital research topics in reconstructive surgery. Harvey was a pioneer who provided the earliest descriptions of the cutaneous vasculature in the 17th century. The concept of vascular territories of the skin was first described by Manchot. The radiographic injection method in cadavers was developed by Salman, who defined more than 80 vascular territories. The arterial system has been thoroughly investigated with the development of regional and free flaps. The concept of axial and random pattern flaps was introduced by McGregor and Morgan. Manchot's vascular territories were refined by Taylor and Palmer as the angiosome concept. Detailed information about the venous circulation is essential for reconstructive surgeries. The concept of intrinsic and extrinsic venocutaneous vascular systems was introduced by Nakajima and led to the development of the venoadipofascial flap. The importance of venous augmentation in flap survival was emphasized by Chang. The lymphatic system was discovered much later than the arterial and venous systems. Aselli was credited for discovering the lacteal vessels in the 17th century; mercury was popularly used as a contrast agent to distinguish lymphatic vessels for the next three centuries. A radiographic method in cadavers was developed by Suami. Lymphatic imaging devices are constantly upgrading, and photoacoustic imaging was recently introduced for three-dimensional visualization of architecture of superficial layers of the lymphatic and venous systems.

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“…When the tissue is irradiated by the short pulse laser, the tissue absorbs the energy resulting in an increase in temperature leading to an increase in pressure in the irradiated volume, resulting in thermal elastic expansion and the formation of ultrasound waves [10][11][12][13] .The pressure rise P(z) can be described as:…”

Section: Photoacoustic and Photothermal Theorymentioning

confidence: 99%

Tissue photothermal effect based on photoacoustic temperature feedback control

zhang

chu²,

cao³

et al. 2022

5th Optics Young Scientist Summit (OYSS 2022)

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hotothermal therapy (PTT) is an alternative to surgery, which is commonly used to treat tumors in intracavitary organs. PTT involves heating the diseased tissue with radiation energy, resulting in tumor necrosis. In order to improve the safety and effectiveness of PT, it is necessary to monitor the tissue temperature in real time and regulate the laser power during PTT. Photoacoustic imaging (PAI) is a non-invasive and non-ionizing imaging method with high resolution and high accuracy. Due to the dependence of the thermal expansion coefficient on temperature, the Grüneisen parameter is linearly proportional to temperature, and the variation of the amplitude of the photoacoustic signal is related to the variation of the Grüneisen parameter. In this study, we propose a system for laser dose regulation with photoacoustic signal temperature feedback based on PID algorithm. The pulsed laser is irradiated on the sample surface, the ultrasonic probe receives the photoacoustic signal generated by the sample, and the photoacoustic signal is collected by the oscilloscope and transmitted to the computer, which generates the corresponding command to the heating laser according to the signal and changes the output power of the heating laser. The experimental results show that this method can effectively control the photothermal damage range.

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Use of photoacoustic imaging to determine the effects of aging on lower extremity lymphatic vessel function

Cited by 8 publications

References 15 publications

Imaging of the Lymphatic Vessels for Surgical Planning: A Systematic Review

Imaging of the Lymphatic Vessels for Surgical Planning: A Systematic Review

Evolution of Anatomical Studies on the Arterial, Venous, and Lymphatic System in Plastic Surgery

Tissue photothermal effect based on photoacoustic temperature feedback control

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