“…A multitude of physiological changes such as catecholamine rush, breakdown of muscle cells, pulmonary embolism, thrombophlebitis and psychological effects such as nightmares, intrusive thoughts, and avoidance responses have also been observed to result from restraint use [11]. Further, potential negative outcomes include increased incidence of falls, contractures, nosocomial infection, pressure ulcers, psychiatric morbidity, mental health problems, aggressive behavior, and mortality [12].…”