Use of platelet concentrates in oral and maxillofacial surgery: an overview

Mihaylova, Zornitsa; Mitev, Vanio; Stanimirov, Pavel; Isaeva, Antonia; Gateva, Natalia; Ishkitiev, Nikolay

doi:10.1080/00016357.2016.1236985

Cited by 36 publications

(36 citation statements)

References 113 publications

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“…APC are a source of platelet‐derived factors obtained by sequestering and concentrating platelets by gradient density centrifugation (Del Fabbro, Gallesio, & Mozzati, ; Mihaylova et al, ). APC contain many factors that promote healing, such as adhesive proteins, pro‐coagulant factors, cytokines and chemokines, anti‐microbial proteins and growth factors such as platelet‐derived growth factor (PDGF), transforming growth factor‐beta (TGF‐b), epidermal growth factors (EGF), and vascular endothelial growth factors (VEGF) (Del Fabbro et al, ; Mihaylova et al, ). Its use in dental surgery is associated with activation of the proliferation, migration, and differentiation of cells in the wound area, especially when the number of cells in the tissue injury site is reduced, increasing the regenerative process (Mihaylova et al, ).…”

Section: Skeleton Side Effects Of N‐bps Prevention and Managementmentioning

confidence: 99%

“…APC contain many factors that promote healing, such as adhesive proteins, pro‐coagulant factors, cytokines and chemokines, anti‐microbial proteins and growth factors such as platelet‐derived growth factor (PDGF), transforming growth factor‐beta (TGF‐b), epidermal growth factors (EGF), and vascular endothelial growth factors (VEGF) (Del Fabbro et al, ; Mihaylova et al, ). Its use in dental surgery is associated with activation of the proliferation, migration, and differentiation of cells in the wound area, especially when the number of cells in the tissue injury site is reduced, increasing the regenerative process (Mihaylova et al, ). Several systematic reviews have identified the use of APC as an adjunct therapy in the prevention and treatment of BRONJ in patients undergoing oral surgery, with a lower incidence on the pathology (Del Fabbro et al, ; Mihaylova et al, ).…”

Section: Skeleton Side Effects Of N‐bps Prevention and Managementmentioning

confidence: 99%

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Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

Vargas-Franco

Castañeda

Rédini

et al. 2018

Journal Cellular Physiology

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Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis of the jaw, delayed dental eruption, atypical femoral fracture, and alterations to the bone growth system, have been described. After an overview of nitrogenous bisphosphonate, the purpose of this article is to describe their mechanisms of action and current applications, review the preclinical and clinical evidence of their side effects in the skeleton ("what we know"), and describe current recommendations for preventing and managing these effects ("what we can do"). Finally, promising future directions on how to limit the occurrence of these side effects will be presented.

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Section: Skeleton Side Effects Of N‐bps Prevention and Managementmentioning

confidence: 99%

Section: Skeleton Side Effects Of N‐bps Prevention and Managementmentioning

confidence: 99%

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

Vargas-Franco

Castañeda

Rédini

et al. 2018

Journal Cellular Physiology

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“…Due to their potential capacity to induce and enhance hard and soft tissue healing, platelet-derived concentrates are agents with great regenerative capacity, and they arereceiving a lot of attention in the field of medicine [25]. The impact of platelet-derived concentrates is the result of their large number of platelets, which includes a wide variety of growth factors and active biomolecules [25].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…The impact of platelet-derived concentrates is the result of their large number of platelets, which includes a wide variety of growth factors and active biomolecules [25].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Mesenchymal Stem Cells and Platelet Derived Concentrates in Regenerative Medicine

Sheykhhasan

2017

JSRT

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In the recent years, the unique characteristics of mesenchymal stem cells (MSCs), consisting their angiogenesis and vascularization activity, as well as anti-inflammatory, anti-ulcer and immunosuppressive features plusdifferentiation capability into multilineage cell, have provided huge favorite among clinicians and researchers that theirs experiments has focused on treatment of different diseases. Additionally, Platelet-derived concentrates, including platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are remarkably being utilized for lesion healing. In this article, we will be discussed a mini-review on the some of the application of mesenchymal stem cells and platelet derived concentrates in regenerative medicine.

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“…2,9, 10 The potential role of GFs in periodontal regeneration is currently the focus of research. In recent years, there has been an increase in the scientific evidence that demonstrates their effectiveness in periodontal regeneration.…”

Section: 578mentioning

confidence: 99%

Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects.Systematic review and meta-analysis.

et al. 2017

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Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects.Systematic review and meta-analysis. INTRODUCTION.Periodontal disease is a multifactorial and complex condition that affects the periodontium. It is characterized by the loss of collagen membrane with the subsequent destruction of the periodontal tissues. 1-3If not treated, the condition will lead to a premature loss of teeth. 2,4The main objectives of periodontal treatment are to eliminate the inflammatory process, prevent the progression of periodontal disease, maintain natural dentition in optimal health and function, and regenerate the lost periodontal tissues.1,5,6 The therapeutic modalities currently used to restore periodontal tissues, such as conventional open flap debridement (COFD), have shown limited potential to achieve the desired results. These techniques fail to regenerate the tissues affected by the disease. In addition, current regenerative procedures offer limited potential for complete periodontal restoration. 4,5One of the consequences of periodontal disease (periodontitis) is the appearance of periodontal intrabony defects (PID) (proximal and/or marginal bone loss). Various biomaterials, based on endogenous regenerative technology, have been used for treatment, in addition to using autogenous and allogeneic bone grafts. However, there is not any biomaterial considered as the gold standard yet for the treatment of PID. 3,5,7,8The key to tissue regeneration is to produce a cascade of coordinated curative events that can stimulate tissue formation. Such modulators include the use of growth factors (GFs), the application of extracellular matrix proteins, binding factors and the use of bone morphogenetic proteins.2,9,10 The potential role of GFs in periodontal regeneration is currently the focus of research. In recent years, there has been an increase in the scientific evidence that demonstrates their effectiveness in periodontal regeneration. 2,5,11-14GFs are present in platelet alpha granules, which upon release allow the multiplication and development of vascular endothelial cells, smooth muscle cells and fibroblasts. In addition, they induce multiple effects on cellular remodeling and modulate the inflammatory reaction in the healing and tissue regeneration processes. 1,2,5,10,14-18GFs include the platelet-derived growth factor (PDGF) and transforming growth factor β (TGF-β). These factors are the most studied in terms of periodontal regeneration. They are known to facilitate bone regeneration after bone grafting by increasing neoangiogenesis, cellular chemotaxis, mitosis, promoting stem cell proliferation and increasing osteoconduction. 1,2,10,14,19Other GFs, such as endothelial growth factor, vascular endothelial growth factor (VEGF), and type 1 insulin-growth factor, have been shown to have the potential to improve and accelerate the regeneration of hard and soft tissues. 1,5,10-15There is a growing interest in the use of platelet-rich plasma (PRP) for the treatment of PID since it is a concentrated s...

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Use of platelet concentrates in oral and maxillofacial surgery: an overview

Cited by 36 publications

References 113 publications

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

Mesenchymal Stem Cells and Platelet Derived Concentrates in Regenerative Medicine

Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects.Systematic review and meta-analysis.

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