Use of platelet‐rich plasma to facilitate wound healing

Abstract

Platelet‐rich plasma (PRP) is widely used nowadays in different fields of medicine, affecting physiological processes including tissue regeneration. The use of PRP in maxillofacial surgical interventions and its efficiency in the improvement of postoperative wound healing were analysed. Patients undergoing plastic and reconstructive surgeries in the maxillofacial region were recruited: 50 patients were enrolled into a control group (received no PPRP injection) and 50 patients were enrolled into a treatment group, where PRP was applied during the surgical procedure. Evaluation of treatment outcomes was carried out by determination of IL‐1β, TNFα, and IL‐6 cytokines levels in the wound‐drain fluid. The stages of wound healing were assessed by cytological analyses and ultrasound within a month period. The use of the PRP has substantially positive effects, contributing to the improvement of the healing process. In the treatment group, fibroblasts, macrophages, and collagen fibres appeared and their quantities increased earlier than when compared with control group patients. The concentration of IL‐1β and TNFα in wound fluid on day 1 and day 5 after operation was higher for the treatment group as opposed to the control group, which was linked to the influence of PRP on inflammatory and granulation phases of the healing process. An ultrasound examination showed less oedema and infiltration in the tissues around the wound of the treatment group.

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

“…Using the full thickness dermal injury model described above, mice were treated with saline, fibrin polymers, fibrin + ULC polymers, fibrin + PLP polymers, or platelet-rich plasma (PRP), which is currently used clinically as a standard-ofcare in wound healing treatments (n = 5 wounds/group). [34][35][36] To obtain PRP, blood was collected from 8 week old C57/B6 mice via cardiac puncture and then centrifuged at 150 × g for 15 minutes to isolate PRP. All fibrin polymers were composed of 2 mg/ml human fibrinogen (FIB 3, Enzyme Research Laboratories, South Bend, IN, USA) and 0.1 U/ml human α-thrombin (Enzyme Research Laboratories, South Bend, IN, USA).…”

Dermabrasion for Scars and Wire Loop Electrocautery for Rhinophyma

“…32 In another study, a randomized control trial in patients undergoing facial plastic and reconstructive surgery receiving an injection of PRP intraoperatively showed an increased number of fibroblasts and collagen, an acceleration in the rate of epithelialization, and reduced edema. 33 A more targeted approach to wound healing would enlist stem cells, which are known to supply the epithelium and enhance their function. A review by Taub and Pham 34 highlighted research on the use of defensins, which are antimicrobial signaling peptides that can signal multipotent stems cells from the hair follicles to supply the epithelium in an injured state.…”

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

“…Therefore, PRP can be remedial in endometriosis. In different studies, however, IL1-B has been shown to increase, and similarly, also decrease with different L-PRPs and P-PRPs 52,53 . In our study, although the foci got smaller with P-PRP and L-PRP, we cannot say that PRP has a therapeutic effect on endometriosis since this reduction was also seen in the control group, and the difference in the reduction of volume was not significant.…”