Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Puricelli, Chiara; Gigliotti, Casimiro Luca; Stoppa, Ian; Sacchetti, Sara; Pantham, Deepika; Scomparin, Anna; Rolla, Roberta; Pizzimenti, Stefania; Dianzani, Umberto; Boggio, Elena; Sutti, Salvatore

doi:10.3390/pharmaceutics15061772

Cited by 16 publications

(8 citation statements)

References 304 publications

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“…Taken together, PLGA NPs alone or with encapsulated DRV in direct treatments or in the presence of a BBB appear to improve the overall immune response in U1 macrophages. In general, synthetic NPs could illicit an inflammatory response [ 73 ]. However, in this case, the increase in some of the pro-inflammatory cytokines and chemokines did not aggravate the HIV progression.…”

Section: Discussionmentioning

confidence: 99%

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice

Zhou,

Godse,

Sinha

et al. 2024

Pharmaceutics

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Although antiretroviral therapy (ART) can suppress peripheral HIV, patients still suffer from neuroHIV due to insufficient levels of ART drugs in the brain. Hence, this study focuses on developing a poly lactic-co-glycolic acid (PLGA) nanoparticle-based ART drug delivery system for darunavir (DRV) using an intranasal route that can overcome the limitation of drug metabolic stability and blood–brain barrier (BBB) permeability. The physicochemical properties of PLGA-DRV were characterized. The results indicated that PLGA-DRV formulation inhibits HIV replication in U1 macrophages directly and in the presence of the BBB without inducing cytotoxicity. However, the PLGA-DRV did not inhibit HIV replication more than DRV alone. Notably, the total antioxidant capacity remained unchanged upon treatment with both DRV or PLGA-DRV in U1 cells. Compared to DRV alone, PLGA-DRV further decreased reactive oxygen species, suggesting a decrease in oxidative stress by the formulation. Oxidative stress is generally increased by HIV infection, leading to increased inflammation. Although the PLGA-DRV formulation did not further reduce the inflammatory response, the formulation did not provoke an inflammatory response in HIV-infected U1 macrophages. As expected, in vitro experiments showed higher DRV permeability by PLGA-DRV than DRV alone to U1 macrophages. Importantly, in vivo experiments, especially using intranasal administration of PLGA-DRV in wild-type mice, demonstrated a significant increase in the brain-to-plasma ratio of DRV compared to the free DRV. Overall, findings from this study attest to the potential of the PLGA-DRV nanoformulation in reducing HIV pathogenesis in macrophages and enhancing drug delivery to the brain, offering a promising avenue for treating HIV-related neurological disorders.

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Section: Discussionmentioning

confidence: 99%

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice

Zhou,

Godse,

Sinha

et al. 2024

Pharmaceutics

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“…The polymers used for drug delivery should be biocompatible and biodegradable, reducing their potential toxicity 114 . Organic and biodegradable artificial polymers, such as silk fibroin, chitosan, and PLGA (poly (D, l ‐lactic‐co‐glycolic acid) are usually employed for this purpose 115–117 . Nanoformulation based on polymers has been used to boost curcumin's cellular activity 84 .…”

Section: Nanotechnology‐based Curcumin Delivery Platformsmentioning

confidence: 99%

“…114 Organic and biodegradable artificial polymers, such as silk fibroin, chitosan, and PLGA (poly (D, L-lactic-co-glycolic acid) are usually employed for this purpose. [115][116][117] Nanoformulation based on polymers has been used…”

Section: Nano Polymersmentioning

confidence: 99%

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Ahmad,

Ahmad

et al. 2024

Cell Biochemistry & Function

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Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness is limited due to poor absorption and rapid elimination from the body. Various curcumin derivatives have also shown anticancer potential in in‐vitro and in‐vivo models. Curcumin can target multiple signaling pathways involved in cancer development/progression or induce cancer cell death through apoptosis. In addition, curcumin and its derivatives could also enhance the effectiveness of conventional chemotherapy, radiation therapy and reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored to overcome the challenges associated with curcumin's delivery, increasing its overall efficacy. The use of an imaging system to track these formulations could also give beneficial information about the bioavailability and distribution of the nano‐curcumin complex. In conclusion, curcumin holds significant promise in the fight against cancer, especially in its nanoform, and could provide precise delivery to cancer cells without affecting normal healthy cells.

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“…Biodegradable polymeric nanoparticles that can encapsulate drugs for sustained release. PLGA nanoparticles have been investigated for the targeted delivery of anti-inflammatory drugs to atherosclerotic lesions [140].…”

Section: Plga (Poly(lactic-co-glycolic Acid)) Nanoparticlesmentioning

confidence: 99%

Photodynamic Therapy for Atherosclerosis

Mytych,

Bartusik-Aebisher,

Łoś

et al. 2024

IJMS

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Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing the need for early detection. Lifestyle modifications and medications form the basis of treatment, and emerging therapies such as photodynamic therapy are being developed. Photodynamic therapy involves a photosensitizer selectively targeting components of atherosclerotic plaques. When activated by specific light wavelengths, it induces localized oxidative stress aiming to stabilize plaques and reduce inflammation. The key advantage lies in its selective targeting, sparing healthy tissues. While preclinical studies are encouraging, ongoing research and clinical trials are crucial for optimizing protocols and ensuring long-term safety and efficacy. The potential combination with other therapies makes photodynamic therapy a versatile and promising avenue for addressing atherosclerosis and associated cardiovascular disease. The investigations underscore the possibility of utilizing photodynamic therapy as a valuable treatment choice for atherosclerosis. As advancements in research continue, photodynamic therapy might become more seamlessly incorporated into clinical approaches for managing atherosclerosis, providing a blend of efficacy and limited invasiveness.

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Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Cited by 16 publications

References 304 publications

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice

Darunavir Nanoformulation Suppresses HIV Pathogenesis in Macrophages and Improves Drug Delivery to the Brain in Mice

Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Photodynamic Therapy for Atherosclerosis

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