Use of polyester leukocyte elimination filters in blood filterability research

Prestorage leukoreduction and low‐temperature filtration reduce hemolysis of stored red cell concentrates

“…Most studies ascribe this improvement of RBC survival of filtered units to the lack of hydrolytic enzymes derived from WBCs dying in the storage container 1,8 , 9 . In addition, it has been assumed that during leukoreduction damaged or fragile cells may be removed selectively because undeformable cells are easily trapped in capillary beds or filter matrices 10,11 . Unlike others, 12 we did not see evidence of increased hemolysis directly after leukoreduction filtration.…”

Influence of prestorage leucocyte depletion and storage time on rheologic properties of erythrocyte concentrates

“…Another explanation may be the reduced degree of RBC anisocytosis as measured with the RDW, indicating a removal of abnormally shaped, less deformable RBCs. It has been shown that a preferential trapping of rigid RBCs may occur within in‐line filters [11]. Finally, the better preserved ATP levels in filtered units may also be a contributing factor, as ATP depletion is associated with reduced cell deformability and hence an increase in high shear viscosity [12].…”

Effects of Leucocyte Depletion on Rheologic Properties of Human CPDA-1 Blood

“…Since all pre- and post-filtration samples were individually corrected to a haematocrit of 45%, RBC loss during the filtration process resulting in ‘haemodilution’ can be excluded as an explanation for this effect. However, it has been shown that a preferential trapping of rigid RBCs may occur within in-line filters [30]. One can, therefore, speculate that this removal of less deformable RBCs could contribute to the decreased high shear viscosity.…”