Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double‐blind controlled trial

Jenkins, Peter; Portmann, Bernard; Eddleston, A. L. W. F.; Williams, Roger

doi:10.1111/j.1600-0676.1982.tb00182.x

Cited by 32 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies showed an amelioration of hepatic symptoms and an enhancement of liver functions with soybean PC supplementation in patients presenting non alcoholic liver damage [102,107]. Moreover, soybean PC (Essentiale ® , see table 2) was given to patients presenting dramatic circulatory problems and simultaneous hepatic disorders, resulting in enhancement of hemodynamics, intrahepatic cholestasis, liver function and in the general lipid metabolism [108].…”

Section: Introductionmentioning

confidence: 99%

Health effects of dietary phospholipids

Küllenberg¹,

Taylor

Schneider³

et al. 2012

Lipids Health Dis

449

305

View full text Add to dashboard Cite

Beneficial effects of dietary phospholipids (PLs) have been mentioned since the early 1900's in relation to different illnesses and symptoms, e.g. coronary heart disease, inflammation or cancer. This article gives a summary of the most common therapeutic uses of dietary PLs to provide an overview of their approved and proposed benefits; and to identify further investigational needs.From the majority of the studies it became evident that dietary PLs have a positive impact in several diseases, apparently without severe side effects. Furthermore, they were shown to reduce side effects of some drugs. Both effects can partially be explained by the fact that PL are highly effective in delivering their fatty acid (FA) residues for incorporation into the membranes of cells involved in different diseases, e.g. immune or cancer cells. The altered membrane composition is assumed to have effects on the activity of membrane proteins (e.g. receptors) by affecting the microstructure of membranes and, therefore, the characteristics of the cellular membrane, e.g. of lipid rafts, or by influencing the biosynthesis of FA derived lipid second messengers. However, since the FAs originally bound to the applied PLs are increased in the cellular membrane after their consumption or supplementation, the FA composition of the PL and thus the type of PL is crucial for its effect. Here, we have reviewed the effects of PL from soy, egg yolk, milk and marine sources. Most studies have been performed in vitro or in animals and only limited evidence is available for the benefit of PL supplementation in humans. More research is needed to understand the impact of PL supplementation and confirm its health benefits.

show abstract

Section: Introductionmentioning

confidence: 99%

Health effects of dietary phospholipids

Küllenberg¹,

Taylor

Schneider³

et al. 2012

Lipids Health Dis

449

305

View full text Add to dashboard Cite

show abstract

“…In addition, PPC promotes liver cell regeneration, and improves lipid metabolism in the blood and liver. Thus, PPC can be applied to the treatment of various acute and chronic liver diseases . Recently, PPC has gained recognition, resulting in increased availability of commercial preparations.…”

Section: Introductionmentioning

confidence: 99%

Detection of related substances in polyene phosphatidyl choline extracted from soybean and in its commercial capsule by comprehensive supercritical fluid chromatography with mass spectrometry compared with HPLC with evaporative light scattering detection

Jiang

Liu

et al. 2015

J of Separation Science

View full text Add to dashboard Cite

Supercritical fluid chromatography with tandem mass spectrometry was used to comprehensively profile polyene phosphatidyl choline (PPC) extracted from soybean. We achieved an efficient chromatographic analysis using a BEH-2EP column (3 × 100 mm(2) , 1.7 μm) with a mobile phase consisting of CO2 and a cosolvent in gradient combination at a flow rate of 1.0 mL/min. The cosolvent consisted of methanol, acetonitrile, and water (containing 10 mM ammonium acetate and 0.2% formic acid). The total single-run time was 7 min. We used this method to accurately detect ten different phospholipids (PLs) during extraction. The limits of quantification for phosphatidyl choline, lyso-phosphatidylcholine (LPC), phosphatidic acid (PA), sphingomyelin, phosphatidyl glycerol, phosphatidyl inositol (PI), cholesterol, cardiolipin, phosphatidyl serine, and phosphatidyl ethanolamine (PE) were 20.6, 19.52, 1.21, 2.38, 0.50, 2.28, 54.3, 0.60, 0.65, and 4.85 ng/mL, respectively. However, adopting the high-performance liquid chromatography with evaporative light scattering detection method issued by the China Food and Drug Administration, only PA, LPC, PE, PI, and PPC could be analyzed accurately, and the limits of quantification were 33.89, 60.5, 30.3, 10.9, and 61.79 μg/mL, respectively. The total single-run time was at the least 20 min. Consequently, the supercritical fluid chromatography with tandem mass spectrometry method was more suitable for the analysis of related PLs.

show abstract

“…One study, phase IIA, double blind, randomized, placebo controlled study including 60 patients with chronic active, non-steroid dependent, ulcerative colitis, showed that 6 g of retarded release phosphatidylcholine rich PL during three months period alleviates inflammatory activity that is caused by ulcerative colitis [50]. Another study showed that polyunsaturated PC is beneficial supplementary treatment for patient management in HBsAg negative chronic active hepatitis, where the condition is inefficiently controlled with standard doses of immunosuppressive therapy [51]. Dietary PC was also shown to alleviate the orotic acid-induced fatty liver in rats OA-, mostly through the reduction of TG synthesis in the liver and improvement of FA β-oxidation [52].…”

Section: Phospholipids (Pl)mentioning

confidence: 99%

Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics

Marković

Ben‐Shabat

Aponick

et al. 2020

IJMS

View full text Add to dashboard Cite

The aim of this work is to analyze relevant endogenous lipid processing pathways, in the context of the impact that lipids have on drug absorption, their therapeutic use, and utilization in drug delivery. Lipids may serve as biomarkers of some diseases, but they can also provide endogenous therapeutic effects for certain pathological conditions. Current uses and possible clinical benefits of various lipids (fatty acids, steroids, triglycerides, and phospholipids) in cancer, infectious, inflammatory, and neurodegenerative diseases are presented. Lipids can also be conjugated to a drug molecule, accomplishing numerous potential benefits, one being the improved treatment effect, due to joined influence of the lipid carrier and the drug moiety. In addition, such conjugates have increased lipophilicity relative to the parent drug. This leads to improved drug pharmacokinetics and bioavailability, the ability to join endogenous lipid pathways and achieve drug targeting to the lymphatics, inflamed tissues in certain autoimmune diseases, or enable overcoming different barriers in the body. Altogether, novel mechanisms of the lipid role in diseases are constantly discovered, and new ways to exploit these mechanisms for the optimal drug design that would advance different drug delivery/therapy aspects are continuously emerging.

show abstract

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double‐blind controlled trial

Cited by 32 publications

References 14 publications

Health effects of dietary phospholipids

Health effects of dietary phospholipids

Detection of related substances in polyene phosphatidyl choline extracted from soybean and in its commercial capsule by comprehensive supercritical fluid chromatography with mass spectrometry compared with HPLC with evaporative light scattering detection

Lipids and Lipid-Processing Pathways in Drug Delivery and Therapeutics

Contact Info

Product

Resources

About