Use of pronestyl in the treatment of ectopic rhythms

Part 8: Advanced Life Support

“…Additional evidence from a case series suggested that procainamide was effective in terminating stable mVT in the hospital setting (LOE 4). 338 Sotalol A double-blind study comparing lidocaine with sotalol documented an improved reversion rate over lidocaine (100 mg) when sotalol (100 mg) was given to patients with spontaneous onset hemodynamically stable sustained mVT in the hospital setting (LOE 1). 339 …”

The Effect of Procaine Amide (Pronestyl) in Clinical Auricular Fibrillation and Flutter

“…However, six of the 13 patients with chronic auricular fibrillation were also restored to sinus rhythm. This result is somewhat better than anticipated since a number of observers5' 7, [8][9][10][11][12][13] have reported the absence of conversions in patients with chronic auricular fibrillation given intravenous procaine amide. It is quite likely that the greater success in more recent investigations using oral procaine amidels' 15 and in the present study was a result of the higher dosage schedules employed.…”

The Action of Procaine and Procaine Amide on the Heart

“…However, its usefulness in the management of clinical arrhythmias in conscious patients has been found to be greatly limited because of its effects on the central nervous system. More recently, procaine amide was introduced (Mark et Newman and Clark, 1951) and both clinical and experimental observations have suggested that this drug is effective in abolishing various types of cardiac arrhythmias and that it is more suitable for clinical purposes than procaine (Berry et al, 1951;Kinsman et al, 1951;Schlachman et al, 1951; Stearns et al, 1952;Enselberg and Lipkin, 1952;Zapata-Diaz et al, 1952; Shack et al, 1952;Lucas and Short, 1952). The present study was undertaken in order to evaluate the effects of procaine and procaine amide on the heart in the experimental animal and to assess the effectiveness of procaine amide in abolishing clinical arrhythmias.…”