“…30,31 In spite of the low rates of wound healing and frequent re-amputation to a more proximal level, PFA is often preferred to TTA given the purported functional benefits. [32][33][34][35][36][37][38][39] For example, it is commonly reported that preserving the ankle joint and residual foot length will contribute to a more normal and less-energy-expensive gait, 32,34,37,[39][40][41] despite good evidence that amputation proximal to the metatarsal heads results in a gait pattern almost indistinguishable from that of persons with TTA. 38,39,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] As the emerging evidence suggests that differences in gait and energy expenditure between PFA and TTA are unlikely, more holistic measures of health such as QoL have become of increasing interest.…”