Use of Purina Pro Plan Veterinary Diet UR Urinary St/Ox to Dissolve Struvite Cystoliths

Torres-Henderson, Camille; Bunkers, Jamie; Contreras, Elena T.; Cross, Emily S.; Lappin, Michael R.

doi:10.1053/j.tcam.2017.07.007

Cited by 11 publications

(13 citation statements)

References 15 publications

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“…8,12,15,22 In two studies, stone burden was reported and none of their cats had as large a stone burden as the patient in this study. 18,19 Initial urolith size has been positively correlated with time to complete dissolution in a previous study, but it is unknown if a larger number of smaller uroliths creating a large stone burden affects dissolution time the same as a single large stone. 19 It is also possible that the owner was non-compliant with the instructions to feed only the test diet; however, at each recheck the client activity and feeding logbook indicated compliance with the guidelines for the study.…”

Section: Discussionmentioning

confidence: 94%

“…Two previous studies also followed up with patient examinations at varying time points for up to 6 months. 16,18 The follow-up with a phone call and not a recheck visit with radiographs and urinalysis as well as physical examination may have missed asymptomatic cystolith recurrence in the patients in this study and is a limitation on the assessment that the diet was adequate for prevention. However, as an effective dissolution diet, it is highly likely that if fed exclusively as directed it would also prevent recurrence.…”

Section: Discussionmentioning

confidence: 95%

“…Previous studies evaluating maintenance dissolution diets have reported mean times to radiographic dissolution of 13 days (range 7–14), 18 13 days (range 6–28), 19 27 days (range 7–52) 19 and 30 days (range 14–56). 20 One study reported a median time to radiographic dissolution of 18 days (range 10–55).…”

Section: Discussionmentioning

confidence: 98%

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Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis

Tefft

Byron

Hostnik

et al. 2020

Journal of Feline Medicine and Surgery

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Objectives The aim of the study was to determine the efficacy of the low struvite relative supersaturation diet in dissolution of feline struvite cystoliths. Methods This was a prospective, open-label, two-center study. Twelve client-owned cats were enrolled based on the radiographic appearance of their uroliths and urinalysis parameters. Cats were fed the test diet exclusively for up to 56 days. Cats were radiographed every other week until radiographic evidence of dissolution occurred or the end of the study period was reached. Cats with radiographically apparent uroliths at the end of the study period underwent cystotomy for stone retrieval and analysis. Results Nine of the 12 cats completed the study. Eight experienced radiographic dissolution; seven of these had complete dissolution within the first month of treatment. One cat, whose owner declined cystotomy after partial dissolution at day 56, had complete radiographic resolution at 70 days of treatment. Two calcium oxalate urolith cores were removed from a cat that had partial radiographic dissolution. Conclusions and relevance The test diet was successful in dissolving suspected struvite cystoliths. As this diet is suitable for maintenance feeding of adult cats, it may be a suitable choice for long-term prevention of feline struvite urolithiasis.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis

Tefft

Byron

Hostnik

et al. 2020

Journal of Feline Medicine and Surgery

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“…Calculolysis has been reported for feline struvite urolithiasis using dietary therapy and usually occurs within one month but has been reported in as little as 8–14 days [3–5]. Antimicrobial therapy for struvite dissolution in cats is not warranted because struvite uroliths in cats are not associated with UTI as they are in dogs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a dry therapeutic urinary diet and concurrent administration of antimicrobials for struvite cystolith dissolution in dogs

et al. 2019

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Background Struvite urolithiasis with bacterial urinary tract infection (UTI) is commonly reported in dogs; few data exist to describe successful dissolution protocols in dogs with naturally occurring disease. We hypothesized that a dry therapeutic urinary diet combined with targeted antimicrobial therapy can effectively dissolve presumptive struvite cystolithiasis in dogs with naturally occurring urease-producing bacterial UTI. Results Ten dogs with presumed infection-induced struvite cystolithiasis based on lower urinary tract signs (LUTS), radiodense cystoliths, and urease-producing bacterial UTI were enrolled. At enrollment, antimicrobials and dry therapeutic urinary diet were dispensed. In addition to lack of radiographic resolution of urolithiasis, dogs with persistent clinical signs were considered non-responders. There was no significant difference in pH between responders and non-responders; USG was significantly higher in the responder group. Recheck visits continued until radiographic dissolution or failure was documented. Five of the 10 dogs achieved radiographic dissolution of cystolithiasis within a median of 31 days (range 19–103). In the other 5 dogs, surgical urolith removal was necessary due to persistent LUTS (3 dogs within 2 weeks) or lack of continued dissolution noted radiographically (1 dog with numerous cystoliths failed at day 91; 1 dog failed by day 57 with questionable owner compliance). Conclusions Dissolution of urinary tract infection induced struvite cystoliths can be accomplished in some dogs fed this dry therapeutic urinary diet in conjunction with antimicrobial therapy. Case selection could increase the likelihood of successful dissolution; however, if calcium phosphate is present, this could also prevent stone dissolution. If clinical signs persist despite diet and antimicrobials, stone removal is advised. Electronic supplementary material The online version of this article (10.1186/s12917-019-1992-8) contains supplementary material, which is available to authorized users.

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“…13 Additionally, prescription diets can be utilized to dissolve existing stones. 27 Though clinical signs had resolved 3 months postoperatively, radiographs were not repeated to confirm the resolution of urolithiasis. However, based on the eventual resolution of clinical signs, successful removal of stones or subsequent dissolution was suspected.…”

Section: Discussionmentioning

confidence: 99%

Urethral obstruction and urolithiasis associated with patent urachus in a 12-week-old kitten

Lavin

Amore

Shaver

2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 12-week-old intact male domestic shorthair kitten presented for dysuria. The patient had a urethral obstruction that was relieved with urinary catheter placement. A cutaneous opening at the umbilicus was identified. Three-view abdominal radiographs and a contrast study revealed a patent urachus with no evidence of urine leakage into the abdomen. An exploratory laparotomy was performed that confirmed a patent urachus, which was excised, and cystic and urethral calculi, which were removed via cystotomy. The patient recovered well from surgery, with a 12 h period of stranguria occurring 2 days postoperatively, attributed to residual inflammation. Calculi analysis revealed struvite stones, likely secondary to infection and inflammation. At the time of writing, 3 months postoperatively, the kitten had one episode of hematuria and inappropriate urination, which resolved with a short course of non-steroidal anti-inflammatory drugs, but had been otherwise been asymptomatic and healthy. Relevance and novel information To our knowledge, this is the first report of urolithiasis and patent urachus in a pediatric feline patient. Based on the occurrence of struvite stones in the presence of a patent urachus in an animal of this age, we suspect that chronic infection and inflammation led to the development of urolithiasis. Correction of the patent urachus resulted in almost complete resolution of clinical signs and no crystal formation was appreciated on recheck urinalysis.

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Use of Purina Pro Plan Veterinary Diet UR Urinary St/Ox to Dissolve Struvite Cystoliths

Cited by 11 publications

References 15 publications

Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis

Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis

Evaluation of a dry therapeutic urinary diet and concurrent administration of antimicrobials for struvite cystolith dissolution in dogs

Urethral obstruction and urolithiasis associated with patent urachus in a 12-week-old kitten

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