Use of radiation therapy for patients with soft-tissue and bone sarcomas

Sheplan, Lawrence; Juliano, Justin J.

doi:10.3949/ccjm.77.s1.06

Cited by 20 publications

(19 citation statements)

References 10 publications

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“…The specific concerns may differ on the basis of the cancer being treated such as the decision of preoperative versus postoperative radiotherapy in soft tissue sarcomas, (12,55) …”

Section: Timing Of Radiotherapy For Local Tumor Controlmentioning

confidence: 99%

Optimal Timing of Whole-Brain Radiation Therapy Following Craniotomy for Cerebral Malignancies

et al. 2015

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“…The specific concerns may differ on the basis of the cancer being treated such as the decision of preoperative versus postoperative radiotherapy in soft tissue sarcomas, (12,55) …”

Section: Timing Of Radiotherapy For Local Tumor Controlmentioning

confidence: 99%

Optimal Timing of Whole-Brain Radiation Therapy Following Craniotomy for Cerebral Malignancies

et al. 2015

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“…Oncology patients are often the most debilitated patients seen by orthopaedic surgeons, and their cases represent a unique challenge to what is considered to be the highest level of evidence. Proposed theories to explain differences involved in closure method include penetration versus intersection of the surgical incision, differences in wound tension, blood perfusion characteristics, and the type of foreign body introduced into the wound (metallic versus nylon) [5,14,17]. Therefore, this retrospective study of 511 patients with pelvic, thigh, and buttock tumor resections and excisions aimed to determine whether identifiable patient and clinical characteristics might have more impact on wound complications than the method of closure and how the time required to close a wound with sutures or staples affected cost.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, recent data have indicated that staples may be associated with higher risks of wound infection after orthopaedic procedures [20]. Other studies have shown that obesity, acute radiotherapy, and other comorbidities affect wound healing [10,12,17]. However, the combined influence of these patient characteristics and wound closure methods on wound outcome has not been adequately investigated.…”

Section: Introductionmentioning

confidence: 99%

Staples Equal Sutures for Skin Closure After Soft Tissue Tumor Resection

Moore

Sellers

Archer

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Wound closure accounts for a relatively constant portion of the time required to complete a surgical case. Both longer closure times and wound infections contribute to higher medical costs and patient morbidity.Questions/purposes We therefore determined whether (1) biologic and treatment factors greater influenced wound fhealing than the choice of sutures or staples; and (2) different times to closure affected cost when sutures or staples are used in patients with musculoskeletal tumors. Methods We retrospectively reviewed 511 patients who had sarcoma resections of the buttock, thigh, and femur from 2003 to 2010; 376 had closure with sutures and 135 with staples. Data were abstracted on patient demographics, comorbidities, select procedural data, and wound complications. Wound complications were defined by hospitalization within 6 months postoperatively for a wound problem, irrigation and débridement, or infection treated with antibiotics. We determined the association between staples versus sutures and wound complications after controlling for confounding factors. The minimum followup was 2 weeks. A prospective, timed analysis of wounds closed with either sutures or staples was also performed. Results We found an association between obesity and radiation and wound complications. Wounds were closed an average of 5.3 minutes faster with staples than with suture (0.29 minutes versus 5.6 minutes, respectively), saving a mean 2.1% of the total operating time although the total operating time was similar in the two groups. Conclusions We found no difference in wound complications after closure with sutures or staples, although obesity and radiation treatment appear to affect wound outcomes. Data suggest that time saved in the operating room by closing with staples compensates for added material costs and does not compromise wound care in patients with lower extremity sarcomas.

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“…ergänzt durch Strahlentherapie zur lokalen Tumorkontrolle. Faktoren, die die Indikation zur Strahlentherapie mit beeinflussen, beinhalten Tumorgrading, -größe, -invasion, frühere Resektion und Status des Tumorrandes, Patientenalter/Allgemeinzustand sowie -nicht an letzter Stelle -die individuelle klinische Entscheidung am jeweiligen Zentrum [20]. Die Rolle der Chemotherapie ist bisher im Wesentlichen auf die Evaluation neuer Studienprotokolle und bei systemischer Abb.…”

Section: Behandlungunclassified

“…Eine potenzielle Ausnahme stellen oberflächliche Tumoren <5 cm mit freien Tumorrändern nach Resektion dar. Bei Tumoren mit niedrigem Grading und positiven/nur knapp tumorfreien Rän-dern wird die Reexzision einer adjuvanten Strahlentherapie im Allgemeinen vorgezogen [20].…”

Section: Spezifische Aspekte Zur Bildgebung Bei Adjuvanter Strahlenthunclassified

Bildgebende Diagnostik und Visualisierung von Bestrahlungsfolgen bei Weichteilsarkomen

2012

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Soft tissue sarcomas are rare malignant neoplasms accounting for only 1% of malignant tumors in adults. Complete surgical resection of tumors is the key to therapeutic success. Indications for adjuvant radiation therapy vary according to the lesion grade. Comprehensive diagnostic imaging significantly contributes to successful preoperative planning procedures. Besides morphological imaging, functional imaging strategies will have an increasing impact on individual risk assessment and contribute to optimized, non-invasive treatment response monitoring.

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Use of radiation therapy for patients with soft-tissue and bone sarcomas

Cited by 20 publications

References 10 publications

Optimal Timing of Whole-Brain Radiation Therapy Following Craniotomy for Cerebral Malignancies

Optimal Timing of Whole-Brain Radiation Therapy Following Craniotomy for Cerebral Malignancies

Staples Equal Sutures for Skin Closure After Soft Tissue Tumor Resection

Bildgebende Diagnostik und Visualisierung von Bestrahlungsfolgen bei Weichteilsarkomen

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