2014
DOI: 10.1186/s12879-014-0593-1
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Use of rapid diagnostic techniques in ICU patients with infections

Abstract: BackgroundInfection is a common complication seen in ICU patients. Given the correlation between infection and mortality in these patients, a rapid etiological diagnosis and the determination of antimicrobial resistance markers are of paramount importance, especially in view of today's globally spread of multi drug resistance microorganisms. This paper reviews some of the rapid diagnostic techniques available for ICU patients with infections.MethodsA narrative review of recent peer-reviewed literature (publish… Show more

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Cited by 47 publications
(34 citation statements)
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“…This should optimize the treatment of infection in critically ill patients [15]. Such developments include various molecular techniques using nucleic acid testing (NAT) based on pathogen lysis, nucleic acid extraction and purification, amplification of nucleic acids by polymerase chain reaction (PCR) and identification by various methods, such as ELISA-based hybridization, fluorescence based real-time detection, liquid or solid phase microarray detection, sequencing and database recognition [16].…”
Section: Microorganisms and Biomarkersmentioning
confidence: 99%
“…This should optimize the treatment of infection in critically ill patients [15]. Such developments include various molecular techniques using nucleic acid testing (NAT) based on pathogen lysis, nucleic acid extraction and purification, amplification of nucleic acids by polymerase chain reaction (PCR) and identification by various methods, such as ELISA-based hybridization, fluorescence based real-time detection, liquid or solid phase microarray detection, sequencing and database recognition [16].…”
Section: Microorganisms and Biomarkersmentioning
confidence: 99%
“…Broadly, index values can be improved by adding new drugs or reducing resistance to available drugs. Rapid identification of the infecting species18 could also improve index values by converting syndrome-based infection baskets (eg, VAP) to organism-based baskets (eg, Pseudomonas VAP), but if rapid tests preclude phenotypic resistance testing, the change could also reduce our ability to predict empiric coverage. Unfortunately, we do not know enough about the effectiveness of many stewardship and infection control strategies,5–9 47 49 in part because it is unclear what outcomes are most relevant, and in part because strategies may be effective in one context, but not in another.…”
Section: Discussionmentioning
confidence: 99%
“…In vivo efficacy, side effects, previous drug exposure and other patient risk factors, previous culture results, rapid diagnostic results, administration route, costs and ecological impacts should also be considered 616 18 55–57…”
Section: Discussionmentioning
confidence: 99%
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“…[1] In addition, ICUs are the epicenters of multidrug-resistant organisms (MDROs) which may increase the chances of inadequate empirical antibiotic therapy resulting in excess mortality. [1] With the emergence of carbapenem-resistant Enterobacteriaceae (CRE) along with the recent reports of colistin resistance,[2] ICUs are facing the prospect of a “postantibiotic era.” This calls for the urgent and definitive measures to prevent the situation slipping into further abyss.…”
Section: Introductionmentioning
confidence: 99%