Use of recombinant vaccinia-rabies virus for oral vaccination of fox cubs (Vulpes vulpes, L) against rabies

Brochier, Bernard; Languet, B.; Blancou, Jean; Kiény, Marie Paule; Lecocq, J. P.; Costy, F.; Desmettre, P; Pastoret, Paul-Pierre

doi:10.1016/0378-1135(88)90055-7

Cited by 46 publications

(21 citation statements)

References 3 publications

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“…Difficulties in vaccinating young foxes have already been mentioned during early trials in our experimental farm with the attenuated rabies SAD strain [7]. However, with the VRG vaccine, young foxes (6 to 12 weeks old) born from non-vaccinated vixens could be efficiently immunised [9].…”

Section: Discussionmentioning

confidence: 99%

“…The possible transmission of tetracycline by the mother (during pregnancy or milk feeding), and any interference between antibody self-production and antibodies of maternal origin must be considered similar in test and control areas because these areas were equally vaccinated during the previous years. Interference between antibodies of maternal origin and active immunity after vaccination has been described in several carnivore species [6] and suggested in the fox by Brochier et al [9] and Vuillaume et al [24].…”

Section: Discussionmentioning

confidence: 99%

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Oral rabies vaccination of foxes with one or two delayed distributions of SAG2 baits during the spring

et al. 2000

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-During the spring of 1997, various protocols of rabies vaccine bait (SAG2) distribution for foxes were compared: in the first test zone, a first distribution was organised at the end of April, followed by a second distribution two weeks later; in the second test zone, there was a first distribution at the same period as for the previous zone, followed by a second distribution four weeks later, at the end of May. In two control zones, a classical single bait distribution was organised during the same periods as for the second distribution in the respective test zones. No statistical differences were observed for adult foxes or fox cubs sampled in the test and control zones neither for baits uptake nor for seroconversion rate. However, seroconversion rates observed in fox cubs population were significantly higher (P < 0.01) in areas vaccinated at the end of May (43 and 56 %) compared with those vaccinated at mid-May (24 and 20%). The vaccinal efficacy of baits was also significantly (P < 0.05) increased for the fox cubs in the areas vaccinated at the end of May (46 and 57%) compared with those vaccinated at mid-May (24 and 25%). This increase in immunological response by fox cubs when vaccinating in late spring must be related to their development. In the early spring, fox cubs are generally too young to have access to baits or to be vaccinated when eating them. For most of these fox cubs, a second distribution will not constitute a booster. Therefore, in order to increase the efficient access of fox cubs to vaccine baits, Spring distribution of baits should preferably be organised during May or June rather than in April. rabies / oral vaccination / fox cub / delayed double bait distributionResumé -Vaccination orale des renards avec une ou deux distributions successives d'appâts SAG2 au printemps. Lors de la campagne de vaccination orale des renards contre la rage en France au printemps 1997, différents protocoles de distribution des appâts vaccinaux (SAG2) ont été comparés : dans une première zone test, une distribution fin avril suivie d'une seconde deux semaines plus tard à la mi-mai et dans une deuxième zone test, une distribution fin avril suivie d'une seconde, Vet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral rabies vaccination of foxes with one or two delayed distributions of SAG2 baits during the spring

et al. 2000

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“…In this strain the cDNA corresponding to the glycoprotein of the ERA strain of rabies virus has been incorporated under the control of the 7.5K promoter into the thymidine kinase (TK) gene of VV. This virus (VVTGgRAB) was demonstrated to be effective for the oral immunization of foxes, raccoons and skunks, eliciting high titres of rabies virus-neutralizing antibodies and conferring long-term protection against rabies (Blancou et al, 1986;Rupprecht et al, 1986Rupprecht et al, , 1988Tolson et al, 1987Tolson et al, , 1988Brochier et al, 1988b). Oral administration of VVTGgRAB was shown to be perfectly safe for several domestic Soria Baltazar et al, 1987), laboratory (Wiktor et al, 1988) and wildlife species Rupprecht et al, 1986Rupprecht et al, , 1988Tolson et al, 1987Tolson et al, , 1988.…”

Section: Introductionmentioning

confidence: 99%

Primary Multiplication Site of the Vaccinia-rabies Glycoprotein Recombinant Virus Administered to Foxes by the Oral Route

Thomas

Brochier

Languet

et al. 1990

Journal of General Virology

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“…The first part of our study dealt with the apathogenicity of the vaccination strain Vnukovo-32/107 for non-target animals -swine, including wild boar, which compete with other animals for vaccination baits distributed in the field (Brochier et al 1988) and can play an important role in their consumption. No less important is the conclusion that prevention and control of diseases in wild boars can be carried out by distribution of such baits (Aubert et al 1994).…”

Section: Resultsmentioning

confidence: 99%

Oral Rabies Immunization of Swine: Use of Vnukovo-32/107 Vaccination Strain

Ondrejka¹,

Ondrejková²,

Svrcek³

et al. 2001

Acta Vet. Brno

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The apathogenicity and antigenic activity of the live oral rabies vaccine prepared from the strain Vnukovo-32/107 were evaluated in two experiments carried out on non-target speciesswine (domestic swine Sus scrofa domestica and wild boar Sus scrofa). The Vnukovo-32/107 vaccination strain has been used to produce oral rabies vaccine Kamark for immunization of free living carnivores. Wild boars compete with foxes for acceptance of baits distributed in the field. The tested vaccination strain for oral application (including very high doses) proved apathogenic to non-target species -swine. Detection and quantification of rabies antibodies were carried out by an immunoenzymatic assay -ELISA, rapid fluorescence focus inhibition test (RFFIT) and virus neutralization test (VNT) on mice on days 30 and 90 post-immunization. The values obtained were expressed in international units (IU/cm 3 ); the value of 0,5 IU/cm 3 was used as a positivity criterium. Antirabic antibodies were detected in more than 50 % of animals in all three groups of two animal sets on day 30 post-immunization. The results obtained show good antigenic activity of the live oral rabies vaccine prepared from the strain Vnukovo-32/107. apathogenicity; antigenic activity Rabies, vaccination strain

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Use of recombinant vaccinia-rabies virus for oral vaccination of fox cubs (Vulpes vulpes, L) against rabies

Cited by 46 publications

References 3 publications

Oral rabies vaccination of foxes with one or two delayed distributions of SAG2 baits during the spring

Oral rabies vaccination of foxes with one or two delayed distributions of SAG2 baits during the spring

Primary Multiplication Site of the Vaccinia-rabies Glycoprotein Recombinant Virus Administered to Foxes by the Oral Route

Oral Rabies Immunization of Swine: Use of Vnukovo-32/107 Vaccination Strain

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