Purpose
To determine the optimal respiratory navigator gating configuration for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI.
Materials and Methods
2D spiral cine DENSE was performed on a 3T MRI using two single-navigator configurations (retrospective, prospective), and a combined “dual-navigator” configuration in 10 healthy adults and 20 healthy children. The adults also underwent breath-hold DENSE as a reference standard for comparisons. Peak left ventricular strains, signal-to-noise ratio (SNR) and navigator efficiency were compared. Subjects also underwent dual-navigator gating with and without visual feedback to determine the effect on navigator efficiency.
Results
There were no differences in circumferential, radial and longitudinal strains between navigator-gated and breath-hold DENSE (p=0.09–0.95) (as confidence intervals, retrospective: [−1.0%,1.1%],[−7.4%,2.0%],[−1.0%,1.2%]; prospective: [−0.6%,2.7%],[−2.8%,8.3%],[−0.3%,2.9%]; dual: [−1.6%,0.5%],[−8.3%,3.2%],[−0.8%,1.9%], respectively). The dual configuration maintained SNR compared to breath-hold acquisitions (16 vs. 18, p=0.06). SNR for the prospective configuration was lower than for the dual navigator in adults (p=0.004) and children (p<0.001). Navigator efficiency was higher (p<0.001) for both retrospective (54%) and prospective (56%) configurations compared to the dual configuration (35%). Visual feedback improved the dual configuration navigator efficiency to 55% (p<0.001).
Conclusion
When quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided since it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration.