Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Abstract

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 23 factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro–in vivo evaluations

“…It is therefore important to understand the influence of formulation variables on the formulation quality with a minimal number of trials and subsequent selection of formulation variables to find optimal formula [21]. Factorial designs are considered the most effective statistical optimization tools in estimating the effects of various formulation variables with minimum experimentation and time, where all factors are studied in all possible combinations by analyzing the influence of individual variables and their interactions using minimum experiments [8,29,36]. Based on the factorial designs, the optimization technique encompasses the generation of model equations for investigated responses over the experimental design to determine the settings of factor values to achieve optimum formulation(s) [22].…”

Floating bioadhesive matrix tablets of ondansetron HCl: Optimization of hydrophilic polymer-blends

“…[1][2] Various natural and synthetic hydrophilic polymers have been continuously applied with a huge diversity to fabricate matrix tablets for sustained-release systems of various drugs. [2][3][4][5] The matrix systems composed of hydrophilic polymers does not disintegrate rapidly, when exposed to the aqueous medium of the stomach; but immediately after hydration, they swell and develop highly viscous surface barrier.…”

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“…The numerical analysis was reported [16] for their optimization, and similarly, optimization carried out to acquire the optimal values of responses based on desirability criterion with the help of Design expert 10.0 software, which led to development of optimized formulation of nifedipine spansules. The…”

“…[16] The pellets were fixed on supports with carbon-glue and coated with gold-palladium under an argon atmosphere using a gold sputter module in a high vacuum evaporator. Samples were then observed with a FEI, Quanta 200 SEM (FEI, Quanta 200 SEM, USA) at 20 kV.…”