Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections

Berdal, Jan-Erik; Skråmm, Inge; Mowinckel, Petter; Gulbrandsen, P.; Bjørnholt, Jørgen Vildershøj

doi:10.1111/j.1469-0691.2005.01230.x

Cited by 94 publications

(65 citation statements)

References 13 publications

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“…Duration from symptom onset has similarly been reported as the most important prognostic factor for infection control in a number of studies [3,6,17,19]. For instance, Crockarell et al [11] suggested débridement and retention of prosthesis have been successful when treatment was commenced within 6 days of symptom onset.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Aggressive Early Débridement for Treatment of Acutely Infected Cemented Total Hip Arthroplasty

Sukeik

Patel

Haddad

2012

Clinical Orthopaedics &Amp; Related Research

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Section: Discussionmentioning

confidence: 99%

“…Treatment options available include débridement with retention of components [3,6,17,19], single-stage revision [20,36], twostage revision and multistage revision [24], long-term suppressive antibiotics, and salvage procedures [36].…”

Section: Introductionmentioning

confidence: 99%

Aggressive Early Débridement for Treatment of Acutely Infected Cemented Total Hip Arthroplasty

Sukeik

Patel

Haddad

2012

Clinical Orthopaedics &Amp; Related Research

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“…Barberan'ın yaptığı bir prospektif kohort çalışmada ise semptom süresi < 1 ay olan hastalarda, levofloksasin + rifampisin kombinasyonu ile bakteriyolojik ve klinik başarı oranı %69.5-80 olarak tespit edilmiştir [25] . Rifampisinin kinolonlarla (siprofloksasin ve levofloksasin) kombinasyon tedavilerinin incelendiği dört çalışmada da %65-100 başarı oranları tespit edilmiştir [24][25][26][27][28] . Bizim çalışmada da siprofloksasin + rifampisin tercih edilen kombinasyonlar arasında yer almaktadır.…”

Section: Tablo 4 Operasyon Sonrası Metisiline Dirençliunclassified

Causative Pathogens at Hip and Knee Prosthetic Joint Infections, Treatment Regimens and Evaluation of Prognosis

Ulu¹,

Şele²,

Kuşçu³

et al. 2016

FLORA

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ÖZET GİRİŞHer yıl tüm dünyada bir milyondan fazla kalça protezi yapılmakta ve pek çok insan protez eklemlerle hayatını sürdürmektedir. Gerek travma gerekse de malignite ve artroza bağlı olarak fonksiyonları ileri derecede bozulmuş eklemlerde oldukça başarılı sonuçlar alınmakta ve hastaların hayat kalitesi artmaktadır. Antimikrobiyal profilaksi ve laminar akımlı cerrahi ortamlar intraoperatif infeksiyon riskini azaltmaktadır. Ancak antimikrobiyal tedavilerdeki ve ortopedideki tüm gelişmelere rağmen halen en korkulan komplikasyonlardan biri infeksiyonlardır. İnfeksiyon çoğu kez protezin çıkarılmasına ve eklem fonksiyon kaybına yol açar ve mortalite oranı %2.7-18 arasındadır [1,2] . İnfek-siyon, ortalama hastanede kalış süresini uzatmakta ve hastanın çoğu kez birden fazla ameliyat geçirmesini gerektirmektedir. Uzun süreli antibiyotik tedavisi ve bazen de süpresyon tedavileri nedeniyle de tedavi maliyeti ciddi oranda artmaktadır.Protez infeksiyonlarında konak, yara yeri, ameliyathane ortamı, operatif teknik ve etken mikroorganizmanın özellikleri infeksiyon riski açısından önem taşır. Protez konulan bölgelerin yakınına önceden herhangi bir cerrahi işlem uygulanması, romatoid artrit (RA) ve diabetes mellitus (DM), yetersiz beslenme, ileri yaş ve şişmanlık gibi bazı predispozan faktörler bulunmaktadır [3] . Protez infeksiyonu tanısında altın standart kültürdür. Etkenin izole edilmesi adına uygun ve zamanında örnekleme yapılması önemlidir. Dokunun durumu ve izole edilen patojenin türü ise protez eklem infeksiyonlarının tedavisini şekillendirmektedir.

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“…Rifampin is thought to penetrate the biofilm, and is recommended in all cases of Staphylococcal PJI treated with DAIR [1,2] . Several studies describe the success rates of a regimen including rifampin [15,[69][70][71] , but only one prospective clinical study has been performed, which also observed higher success rates when rifampin was added to the antibiotic regimen [72] . Another, more recent study, compared a prospective rifampin group with a retrospective rifampin and a retrospective non-rifampin group [73] .…”

Section: Systemic Antibiotic Treatmentmentioning

confidence: 99%

Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts

Kuiper

Willink

Moojen

et al. 2014

WJO

109

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Periprosthetic joint infection (PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively (4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one or more positive culture results. Debridement, antibiotics and implant retention (DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus (aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one-or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. Key words: Arthroplasty; Prosthesis; Infection; Periprosthetic joint infection; Retention; Debridement antibiotics and implant retention; Debridement; Acute Core tip: Acute periprosthetic joint infection (PJI) is a major complication after total joint arthroplasty, and occurs either postoperatively or via hematogenous spreading. Debridement, antibiotics and implant retention (DAIR), the primary treatment for acute PJI, should be performed as soon as possible after the development of symptoms, and has success rates around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. Sys- REVIEW

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Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections

Cited by 94 publications

References 13 publications

Aggressive Early Débridement for Treatment of Acutely Infected Cemented Total Hip Arthroplasty

Aggressive Early Débridement for Treatment of Acutely Infected Cemented Total Hip Arthroplasty

Causative Pathogens at Hip and Knee Prosthetic Joint Infections, Treatment Regimens and Evaluation of Prognosis

Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts

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